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The Institute of Psychiatry, Psychology and Neuroscience (IoPPN) is a research institution dedicated to discovering what causes mental illness and diseases of the brain. In addition, its aim is to help identify new treatments for them and ways to prevent them in the first place. The IoPPN is a faculty of King's College London, England, previously known as the Institute of Psychiatry (IoP).
Psychiatric genetics is a subfield of behavioral neurogenetics and behavioral genetics which studies the role of genetics in the development of mental disorders. The basic principle behind psychiatric genetics is that genetic polymorphisms are part of the causation of psychiatric disorders.
The Collaborative Studies on the Genetics of Alcoholism (COGA) is an eleven-center research project in the United States designed to understand the genetic basis of alcoholism. Research is conducted at University of Connecticut, Indiana University, University of Iowa, SUNY Downstate Medical Center at Brooklyn, Washington University in St. Louis, University of California at San Diego, Rutgers University, University of Texas Health Science Center at San Antonio, Virginia Commonwealth University, Icahn School of Medicine at Mount Sinai, and Howard University.
Child and adolescent psychiatry is a branch of psychiatry that focuses on the diagnosis, treatment, and prevention of mental disorders in children, adolescents, and their families. It investigates the biopsychosocial factors that influence the development and course of psychiatric disorders and treatment responses to various interventions. Child and adolescent psychiatrists primarily use psychotherapy and/or medication to treat mental disorders in the pediatric population.
Irving Isadore Gottesman was an American professor of psychology who devoted most of his career to the study of the genetics of schizophrenia. He wrote 17 books and more than 290 other publications, mostly on schizophrenia and behavioral genetics, and created the first academic program on behavioral genetics in the United States. He won awards such as the Hofheimer Prize for Research, the highest award from the American Psychiatric Association for psychiatric research. Lastly, Gottesman was a professor in the psychology department at the University of Minnesota, where he received his Ph.D.
Neurogenetics studies the role of genetics in the development and function of the nervous system. It considers neural characteristics as phenotypes, and is mainly based on the observation that the nervous systems of individuals, even of those belonging to the same species, may not be identical. As the name implies, it draws aspects from both the studies of neuroscience and genetics, focusing in particular how the genetic code an organism carries affects its expressed traits. Mutations in this genetic sequence can have a wide range of effects on the quality of life of the individual. Neurological diseases, behavior and personality are all studied in the context of neurogenetics. The field of neurogenetics emerged in the mid to late 20th century with advances closely following advancements made in available technology. Currently, neurogenetics is the center of much research utilizing cutting edge techniques.
Behavioural genetics, also referred to as behaviour genetics, is a field of scientific research that uses genetic methods to investigate the nature and origins of individual differences in behaviour. While the name "behavioural genetics" connotes a focus on genetic influences, the field broadly investigates the extent to which genetic and environmental factors influence individual differences, using research designs that allow removal of the confounding of genes and environment. Behavioural genetics was founded as a scientific discipline by Francis Galton in the late 19th century, only to be discredited through association with eugenics movements before and during World War II. In the latter half of the 20th century, the field saw renewed prominence with research on inheritance of behaviour and mental illness in humans, as well as research on genetically informative model organisms through selective breeding and crosses. In the late 20th and early 21st centuries, technological advances in molecular genetics made it possible to measure and modify the genome directly. This led to major advances in model organism research and in human studies, leading to new scientific discoveries.
Wim E. Crusio is a Dutch behavioral neurogeneticist and a directeur de recherche with the French National Centre for Scientific Research in Talence, France.
Kenneth S. Kendler is an American psychiatrist best known for his pioneering research in psychiatric genetics, particularly the genetic causes of schizophrenia. Kendler is one of the highest cited psychiatry researchers. Between 1990 and 1998 he was the 2nd highest cited psychiatrist, and for the 1997-2007 decade he was ranked 4th by Thomson Reuters' Science Watch. He has authored over 1,200 papers and in 2016 his h-index was 126. Kendler's group was also noted for the replication of a study of Avshalom Caspi on the interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression.
Lindon J. Eaves (1944–2022) was a behavior geneticist and priest who has published on topics as diverse as the heritability of religion and psychopathology. His research encompasses the development of mathematical models reflecting competing theories of the causes and familial transmission of human human differences, the design of studies for the resolution, analytical methods for parameter estimation and hypothesis-testing and application to substantive questions about specific (human) traits. He was the first to consider standardized variance components for heritability estimates and was the first to consider the effects of living with a relative on the behavior of a person. Furthermore, he was the first to think about genotype x age interaction and set up the algebra to study the effects of genes working in males as well as females, making it possible to use twins pairs of opposite-sex. Together with Nick Martin, he wrote many classic papers, one of which is "The genetic analysis of covariance structure". They also wrote the book, Genes, culture and personality: An empirical approach. In 2012, a Festschrift was held in Edinburgh dedicated to Eaves' work; the proceedings were subsequently published in Behavior Genetics.
Daniel H. Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He also directs the UCLA Neurogenetics Program and the UCLA Center for Autism Research and Treatment (CART), and holds the Gordon and Virginia MacDonald Distinguished Chair of Human Genetics there. Since March 1, 2016, he has served as the Senior Associate Dean and Associate Vice Chancellor for Precision Medicine at UCLA. His brother, Michael Geschwind, is also a professor of neurology, and behavioral neurology pioneer Norman Geschwind is his father's first cousin.
The Virginia Institute for Psychiatric and Behavioral Genetics is a human genetics research center, located at Virginia Commonwealth University (VCU), that aims to study the role played by genetic factors in the etiology of psychiatric conditions and substance abuse. It was co-founded in 1996 by VCU psychiatry professors Kenneth Kendler and Lindon Eaves. Kendler serves as the Institute's director and the director of its Psychiatric Genetics Research Program, while Eaves is the director of the Institute's Genetic Epidemiology Research Group. The PGRP and GERG are subsidiaries of the Department of Psychiatry and the Department of Human and Molecular Genetics, respectively, at the VCU School of Medicine. The Institute's associate director is Michael Neale. In 2017, the Virginia General Assembly passed a bill commending Kendler and the VIPBG, describing the latter as "...an exciting, highly collaborative research environment with a strong record of funding, research, and training, including more than 140 predoctoral and postdoctoral students over the past decade".
Jonathan Flint is a British behavior geneticist and Professor in Residence in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. He is also a senior scientist in the Center for Neurobehavioral Genetics at UCLA's Semel Institute for Neuroscience and Human Behavior.
Benjamin Michael Neale is a statistical geneticist with a specialty in psychiatric genetics. He is an institute member at the Broad Institute as well as an associate professor at both Harvard Medical School and the Analytic and Translational Genetics Unit at Massachusetts General Hospital. Neale specializes in genome-wide association studies (GWAS). He was responsible for the data analysis of the first GWAS on attention-deficit/hyperactivity-disorder, and he developed new analysis software such as PLINK, which allows for whole-genome data to be analyzed for specific gene markers. Related to his work on GWAS, Neale is the lead of the ADHD psychiatric genetics and also a member of the Psychiatric GWAS Consortium analysis committee.
Ming Tso Tsuang is an American psychiatrist and Distinguished Professor of Psychiatry at the University of California, San Diego. He is considered a pioneering researcher in the genetic epidemiology of schizophrenia and other severe mental disorders. Tsuang has authored and co-authored more than 600 publications and serves as founding and senior editor of the American Journal of Medical Genetics Part B.
Michael C. O'Donovan is a Scottish psychiatric geneticist who researches the genetics of schizophrenia. He is a clinical professor in the Division of Psychological Medicine and Clinical Neurosciences and the deputy director of the MRC Centre for Neuropsychiatric Genetics and Genomics at the Cardiff University School of Medicine in Cardiff, Wales. He also leads the Schizophrenia Group of the Psychiatric Genomics Consortium. Educated at Glasgow University, he also serves as Academic Psychiatry Lead for the Royal College of Psychiatrists in Wales. He was lead author of a 2014 study in Nature which identified over 100 genetic loci associated with an increased risk of schizophrenia. The study, the largest of its kind undertaken at the time, was covered extensively in the media. It was also praised by Thomas Insel, the then-director of the National Institute of Mental Health, who described the study as "a big step forward".
Matthew C. Keller is an American behavioral and psychiatric geneticist. He is the Director of the Institute for Behavioral Genetics and a professor in the Department of Psychology and Neuroscience at the University of Colorado Boulder. He is known for his criticism of the candidate gene approach and for development of approaches in quantitative genetics.
Hermine H. M. Maes is a Belgian behavioral geneticist and Associate Professor in both the Department of Human and Molecular Genetics at the Virginia Commonwealth University School of Medicine and the Virginia Institute for Psychiatric and Behavioral Genetics. She received her Ph.D. from the Katholieke Universiteit Leuven in 1992. Maes' research focuses on the methodology of genetic epidemiology and the relationships between physical and mental health. Her husband and sometime research partner is Michael Neale.
James Shields was a Scottish psychiatric geneticist and twin researcher. In the 1960s, he worked with Irving Gottesman on a twin study of schizophrenia at the Medical Research Council Psychiatric Genetics Unit at Maudsley Hospital in London, England. This study, known as the Maudsley twin study, is now considered a landmark in the field. He had previously begun working for Eliot Slater at Maudsley after serving in the United Kingdom's Royal Artillery during World War II. He was a fellow of the Eugenics Society and the International Society for Twin Studies. After Shields died in 1978, Gottesman founded the annual James Shields Award for Lifetime Contributions to Twin Research in his honor.
Sarah Elizabeth Medland is Professor and Psychiatric Genetics Group Leader at the QIMR Berghofer Medical Research Institute in Herston, Brisbane, Australia. She played a major role in the development of the ENIGMA brain imaging consortium.
References
- 1 2 "Michael Neale Curriculum Vitae". academia.edu. Retrieved 9 July 2018.
- ↑ "Michael Neale, Ph.D. Recipient of VCU Distinguished Scholarship Award". Virginia Institute for Psychiatric and Behavioral Genetics. 25 August 2017. Retrieved 9 July 2018.
