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Michael Rush Lerner is a dermatologist in San Diego, California. [1]
Lerner was born in Portland, Oregon.[ citation needed ]
He discovered snRNPs with Joan A. Steitz, [2] STEP (with Paul Lombroso), created the melanophore based GPCR bioassay and demonstrated that Smoothened is a GPCR. [2]
San Diego is a city on the Pacific Ocean coast in Southern California located immediately adjacent to the Mexico–United States border. With a population of over 1.3 million residents, the city is the eighth-most populous in the United States and the second-most populous in the state of California after Los Angeles. The city is the county seat of San Diego County, which had a population of nearly 3.3 million people as of 2021. San Diego is known for its mild year-round Mediterranean climate, extensive beaches and parks, its long association with the United States Navy, and its recent emergence as a healthcare and biotechnology development center.
Michael or Mike Lerner may refer to:
San Diego Comic-Con (SDCC) is a comic book convention and multi-genre entertainment event held annually in San Diego, California, since 1970. It is held at the San Diego Convention Center. Originally showcasing primarily comic books and science fiction/fantasy media, Comic-Con has grown to include a large range of pop culture and entertainment elements across virtually all genres.
The San Diego Union-Tribune is a metropolitan daily newspaper published in San Diego, California, that has run since 1868. Its name derives from a 1992 merger between the two major daily newspapers at the time, The San Diego Union and the San Diego Evening Tribune. The name changed to U-T San Diego in 2012 but was changed again to The San Diego Union-Tribune in 2015.
State Route 76 (SR 76) is a state highway 52.63 miles (84.70 km) long in the U.S. state of California. It is a much used east–west route in the North County region of San Diego County that begins in Oceanside near Interstate 5 (I-5) and continues east. The highway is a major route through the region, passing through the community of Bonsall and providing access to Fallbrook. East of the junction with I-15, SR 76 goes through Pala and Pauma Valley before terminating at SR 79.
In biochemistry, an orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. If a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan". Conversely, the term orphan ligand refers to a biological ligand whose cognate receptor has not yet been identified.
Nathan Colbert Jr. was an American professional baseball player. He played in Major League Baseball (MLB) as a first baseman from 1966 to 1976, most prominently as a member of the newly formed San Diego Padres, who joined the league as an expansion team in 1969. He was among the inaugural inductees into the Padres Hall of Fame.
Alliant International University is a private for-profit university with its main campus in San Diego, five additional campuses in California and one campus in Phoenix, Arizona. Its enrollment is approximately 4,000 students, of whom 95% are graduate students.
snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.
Richard Alan Lerner was an American research chemist. He was best known for his work on catalytic antibodies and combinatorial antibody libraries. Lerner served as President of The Scripps Research Institute (TSRI) from 1987 until January 1, 2012, and was a member of its Skaggs Institute for Chemical Biology, in La Jolla, California.
Joan Elaine Argetsinger Steitz is Sterling Professor of Molecular Biophysics and Biochemistry at Yale University and Investigator at the Howard Hughes Medical Institute. She is known for her discoveries involving RNA, including ground-breaking insights into how ribosomes interact with messenger RNA by complementary base pairing and that introns are spliced by small nuclear ribonucleic proteins (snRNPs), which occur in eukaryotes. In September 2018, Steitz won the Lasker-Koshland Award for Special Achievement in Medical Science. The Lasker award is often referred to as the 'American Nobel' because 87 of the former recipients have gone on to win Nobel prizes.
Arena Pharmaceuticals, Inc. is an American biopharmaceutical company founded in 1997 and headquartered in San Diego, California. The company has small molecule drugs in development for possible clinical utility in multiple therapeutic areas. The company's most advanced investigational clinical programs are ralinepag in testing for pulmonary arterial hypertension (PAH), etrasimod in evaluation for inflammatory indications and APD371 for the treatment of pain associated with Crohn's disease. In 2016, the company downsized and shifted its focus to developing new drugs currently being tested in clinical trials. In December 2021, Pfizer announced that it had agreed to acquire Arena for $6.7 billion in cash. In March 2022, it was announced the acquisition by Pfizer had been concluded.
The Epstein–Barr virus–encoded small RNAs (EBERs) are small non-coding RNAs localized in the nucleus of human cells infected with Epstein–Barr virus (EBV). First discovered in 1981, EBERs are the most abundant RNAs present in infected cells. EBERs interact with several host proteins to form ribonucleoprotein (RNP) complexes. Although a precise function for EBERs remains elusive, roles in transformation and oncogenesis are proposed. They have also been shown to be present in exosomes released from infected cells and could be involved in cell to cell interaction.
Aaron Bunsen Lerner, also known in scientific articles as Aaron B. Lerner, was an American physician, researcher and professor.
The San Diego State Aztecs men's basketball team is the men's college basketball program that represents San Diego State University. The Aztecs compete in NCAA Division I as a member of the Mountain West Conference (MW). The team plays its home games at Viejas Arena.
San Diego County, officially the County of San Diego, is a county in the southwestern corner of the U.S. state of California. As of the 2020 census, the population was 3,298,634, making it California's second-most populous county and the fifth-most populous in the United States. Its county seat is San Diego, the second-most populous city in California and the eighth-most populous city in the United States. It is the southwesternmost county in the 48 contiguous United States, and is a border county. It is also home to 18 Native American tribal reservations, the most of any county in the United States.
The Los Angeles Chargers are a professional American football team in the National Football League (NFL) based in the Los Angeles Area. The club began play in 1960 as a charter member of the American Football League (AFL), and spent its first season in Los Angeles before moving to San Diego in 1961. They returned to Los Angeles in 2017. The Chargers created their Hall of Fame in 1976. Eligible candidates for the Hall of Fame must have been retired for at least four seasons. Selections are made by a five-member committee chaired by Dean Spanos, Chargers vice-chairman. As of 1992, other committee members included Bob Breitbard, founder of the San Diego Hall of Champions; Ron Fowler, president of the Greater San Diego Sports Association; Jane Rappoport, president of the Charger Backers; and Bill Johnston, the team's director of public relations.
Mitchel P. Goldman, is an American dermatologic surgeon, cosmetic surgeon, dermatologist, and phlebologist, and the founder and director of Cosmetic Laser Dermatology. He is also a past president of the American Society for Dermatologic Surgery, the American College of Phlebology, the San Diego County Dermatology Society, and the Sonoran Dermatology Society.
Joan Heller Brown is an American pharmacologist. She is Distinguished Professor and Chair of the Department of Pharmacology at UC San Diego School of Medicine. She is known for fundamental contributions to the understanding of G-protein coupled receptors (GPCRs) — molecules that span cell membranes, where they transmit messages between cells and their environments — and how GPCRs regulate cell growth and survival, in healthy and various disease states. Many therapeutic drugs work by influencing GPCRs, thus Heller Brown's discoveries have been crucial to their development.
Azadeh Shirazi is an American surgeon and cosmetic dermatologist who has been featured on the DoctorsTV show for being the creator of the Eyeglow procedure. She has authored numerous peer-reviewed journal articles and is also invited on national and local news networks such as Fox News, Cheddar, NewsMax, NBC, KUSI to discuss various medical topics, therapies, and aesthetic trends.
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