Mitochondrial pyruvate carrier

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The mitochondrial pyruvate carriers are composed of: [1] [2]

The pyruvate carriers are involved in mitochondrial metabolism but it is possible to compensate for their loss of function. [3] They have been studied for a role in cardiac stress adaption. [4]

Inhibitors

MPC inhibitors include drugs like UK-5099 (JXL001), JXL069, and PP405. [5] [6]

References

  1. ↑ McCommis, Kyle S.; Finck, Brian N. (15 March 2015). "Mitochondrial pyruvate transport: a historical perspective and future research directions". Biochemical Journal. 466 (3): 443–454. doi:10.1042/BJ20141171. PMC   4464838 . PMID   25748677.
  2. ↑ "SLC54 Mitochondrial pyruvate carriers | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY". www.guidetopharmacology.org. Retrieved 3 December 2023.
  3. ↑ Bender, Tom; Martinou, Jean-Claude (1 October 2016). "The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?" . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863 (10): 2436–2442. doi:10.1016/j.bbamcr.2016.01.017. ISSN   0167-4889. PMID   26826034.
  4. ↑ Zhang, Yuan; Taufalele, Paul V.; Cochran, Jesse D.; Robillard-Frayne, Isabelle; Marx, Jonas Maximilian; Soto, Jamie; Rauckhorst, Adam J.; Tayyari, Fariba; Pewa, Alvin D.; Gray, Lawrence R.; Teesch, Lynn M.; Puchalska, Patrycja; Funari, Trevor R.; McGlauflin, Rose; Zimmerman, Kathy; Kutschke, William J.; Cassier, Thomas; Hitchcock, Shannon; Lin, Kevin; Kato, Kevin M.; Stueve, Jennifer L.; Haff, Lauren; Weiss, Robert M.; Cox, James E.; Rutter, Jared; Taylor, Eric B.; Crawford, Peter A.; Lewandowski, E. Douglas; Des Rosiers, Christine; Abel, E. Dale (November 2020). "Mitochondrial pyruvate carriers are required for myocardial stress adaptation". Nature Metabolism. 2 (11): 1248–1264. doi:10.1038/s42255-020-00288-1. ISSN   2522-5812. PMC   8015649 . PMID   33106689.
  5. ↑ Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME (February 2021). "Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss". J Med Chem. 64 (4): 2046–2063. doi:10.1021/acs.jmedchem.0c01570. PMC   8939290 . PMID   33534563.
  6. ↑ Brown, Lane (12 August 2025). "The Great Unbalding Draws Nearer". Intelligencer. Retrieved 24 October 2025.
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