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The Duesberg hypothesis is the claim that AIDS is not caused by HIV, but, instead, that AIDS is caused by noninfectious factors such as recreational and pharmaceutical drug use and that HIV is merely a harmless passenger virus. The hypothesis was popularized by University of California, Berkeley professor Peter Duesberg, from whom the hypothesis gets its name. The scientific consensus is that the Duesberg hypothesis is incorrect and that HIV is the cause of AIDS. The most prominent supporters of the hypothesis are Duesberg himself, biochemist and vitamin proponent David Rasnick and journalist Celia Farber. The scientific community generally contends that Duesberg's arguments in favor of the hypothesis are the result of cherry-picking predominantly outdated scientific data and selectively ignoring evidence that demonstrates HIV's role in causing AIDS.
The spread of HIV/AIDS has affected millions of people worldwide; AIDS is considered a pandemic. The World Health Organization (WHO) estimated that in 2016 there were 36.7 million people worldwide living with HIV/AIDS, with 1.8 million new HIV infections per year and 1 million deaths due to AIDS. Misconceptions about HIV and AIDS arise from several different sources, from simple ignorance and misunderstandings about scientific knowledge regarding HIV infections and the cause of AIDS to misinformation propagated by individuals and groups with ideological stances that deny a causative relationship between HIV infection and the development of AIDS. Below is a list and explanations of some common misconceptions and their rebuttals.
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often persists as a latent infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is Human gammaherpesvirus 8, or HHV-8 in short. Like other herpesviruses, its informal names are used interchangeably with its formal ICTV name. This virus causes Kaposi's sarcoma, a cancer commonly occurring in AIDS patients, as well as primary effusion lymphoma, HHV-8-associated multicentric Castleman's disease and KSHV inflammatory cytokine syndrome. It is one of seven currently known human cancer viruses, or oncoviruses. Even after so many years of discovery of KSHV/HHV8, there is no known cure for KSHV associated tumorigenesis.
AIDS is caused by a human immunodeficiency virus (HIV), which originated in non-human primates in Central and West Africa. While various sub-groups of the virus acquired human infectivity at different times, the present pandemic had its origins in the emergence of one specific strain – HIV-1 subgroup M – in Léopoldville in the Belgian Congo in the 1920s.
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss.
Taiwan's epidemic of HIV/AIDS began with the first case reported in December 1984. On 17 December 1990 the government promulgated the AIDS Prevention and Control Act. On 11 July 2007, the AIDS Prevention and Control Act was renamed the HIV Infection Control and Patient Rights Protection Act.
Sexually transmitted infections (STIs), also referred to as sexually transmitted diseases (STDs) and the older term venereal diseases, are infections that are spread by sexual activity, especially vaginal intercourse, anal sex, and oral sex. STIs often do not initially cause symptoms, which results in a risk of passing the infection on to others. Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain. Some STIs can cause infertility.
The Democratic Republic of the Congo was one of the first African countries to recognize HIV, registering cases of HIV among hospital patients as early as 1983.
Anal dysplasia is a pre-cancerous condition which occurs when the lining of the anal canal undergoes abnormal changes. It can be classified as low grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL). Most cases are not associated with symptoms, but people may notice lumps in and around the anus.
Frederick Wabwire-Mangen is a Ugandan physician, public health specialist and medical researcher. Currently he is Professor of Epidemiology and Head of Department of Epidemiology & Biostatistics at Makerere University School of Public Health. Wabwire-Mangen also serves as the Chairman of Council of Kampala International University and a founding member of Accordia Global Health Foundation’s Academic Alliance
David M. Serwadda is a Ugandan physician, medical researcher, academic, public health specialist and medical administrator. Currently he is a Professor of Public Health at Makerere University School of Public Health, one of the schools of Makerere University College of Health Sciences, a semi-autonomous constituent college of Makerere University, the oldest university in Uganda. Serwadda is also a founding member of Accordia Global Health Foundation's Academic Alliance.
Warren Winkelstein Jr. was an American epidemiologist, professor in the School of Public Health at the University of California, Berkeley, and a member of the Institute of Medicine of the U.S. National Academy of Sciences. During the 1960s Winkelstein was considered one of the leading epidemiologists of the time.
David DuPuy Celentano is a noted epidemiologist and professor who has contributed significantly to the promotion of research on HIV/AIDS and other sexually transmitted infections (STIs). He is the Charles Armstrong chair of the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. He holds joint appointments with the school’s departments of Health Policy and Management, Health Behavior and Society, and International Health, and the Johns Hopkins University School of Medicine’s Division of Infectious Diseases.
Hendrik Streeck is a German researcher of human immunodeficiency virus, epidemiologist and clinical trialist. He is professor of virology and the director of the Institute of Virology and HIV Research at the University Bonn.
Mads Melbye is director of the Cancer Institute in Denmark (DCRC). He earned his M.D. degree from University of Aarhus, Denmark, in 1983, and a DMSc degree from the same university in 1988. His thesis work was partly done as a fellow in the epidemiology program 1985-1986 at the National Cancer Institute, NIH, US. After clinical training he became senior investigator in 1989 at the Danish Cancer Registry in Copenhagen, and in 1991 state epidemiologist at Statens Serum Institut (SSI) in Copenhagen. In 1992, Melbye was given a personal chair in infectious disease and cancer epidemiology by the Danish minister for research and education. He founded the Department of Epidemiology Research at SSI and to day this department is one of Europe's largest epidemiology research milieus. From 1998 to 2008 he was foreign adjunct professor at Medical Epidemiology and Biostatistics Branch at Karolinska University in Stockholm. In 2012 he established the Danish National Biobank which is one of the biggest biobanks in the world today. Same year he became senior vice-president at Statens Serum Institut in Copenhagen and from 2016 till 2020 president and CEO. He is presently professor of medical epidemiology at University of Copenhagen and affiliated with Department of Genetics at Stanford University School of Medicine.
Sten H. Vermund is the Anna M.R. Lauder Professor of Public Health, and former Dean (2017-2022) of the Yale School of Public Health, and also serves as a Professor in Pediatrics at the Yale School of Medicine. He is a pediatrician and infectious disease epidemiologist focused on diseases of low and middle-income countries.
Gypsyamber D'Souza is an American epidemiologist. She is a professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health. D'Souza researches infectious diseases, cancer prevention, and translational epidemiology. She is a principal investigator of the Multicenter AIDS Cohort Study / Women's Interagency HIV Study Combined Cohort Study (Mwccs.org).
Fred Mhalu is a microbiologist and medical researcher from Tanzania. His main area of study revolves around infectious diseases and intervention. Ever since 1986, he has been a main contributor to the information about AIDS in Africa. As a co-coordinator of a Tanzanian-Swedish research collaboration called TANSWED, he was involved in many research projects that lead to multiple publications in medical journals. His more recent research on HIV/AIDS involves studying breast cancer in HIV prevalent areas, evaluating prevention of mother-to-child-transmission of HIV-1, and observing sexual behaviors of high risk populations for HIV-1.
Godefridus Johannes Petrus "Frits" van Griensven is a pioneering Dutch scientist in epidemiology, sociology and public health. Most of his work is on addressing the HIV epidemic among men who have sex with men and other HIV key populations.
References
- 1 2 3 4 "Morten Frisch". SSI. Retrieved 21 August 2015.
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