Multiple sclerosis functional composite

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The Multiple Sclerosis Functional Composite (MSFC) is a clinical trial outcome measure of assessing the severity of multiple sclerosis primarily used in research. [1] The score is based on a combination of timed tests of walking, arm function, and cognitive ability. [1] It was developed over two years from 1994 to 1996 by the National Multiple Sclerosis Society. [1] [2]

MSFC was developed to improve the standard measure of MS disability for clinical trials and to create a multidimensional metric of overall MS clinical status. The evaluation includes a three-part performance scale:

An integrated MSFC score is calculated using z-scores. [3]

References

  1. 1 2 3 Rudick RA, Cutter G, Reingold S (October 2002). "The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials". Multiple Sclerosis. 8 (5): 359–65. doi:10.1191/1352458502ms845oa. PMID   12356200. S2CID   31529508.
  2. ↑ Balcer LJ, Baier ML, Cohen JA, Kooijmans MF, Sandrock AW, Nano-Schiavi ML, et al. (November 2003). "Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite" . Neurology. 61 (10): 1367–73. doi:10.1212/01.WNL.0000094315.19931.90. PMID   14638957. S2CID   17583827.
  3. ↑ Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T (March 2014). "Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis". BMC Neurology. 14 (1): 58. doi: 10.1186/1471-2377-14-58 . PMC   3986942 . PMID   24666846.
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