Myospherulosis

Last updated June 19, 2025

Myospherulosis, also known as spherulocytosis,^[1] is a foreign body-type granulomatous reaction to lipid-containing material and blood.^[1]^[2]

It may be seen in various settings including:

Fat necrosis.^[1]
Malignancy, e.g. renal cell carcinoma.^[3]
Placement of topical tetracycline in a petrolatum base into a surgical site.

The resultant histopathologic pattern is most unusual and initially was mistakenly thought to represent a previously undescribed endosporulating fungus.

References

1 2 3 Godbersen, GS.; Kleeberg, J.; Lüttges, J.; Werner, JA. (Sep 1995). "[Spherulocytosis (myospherulosis) of the paranasal sinuses]". HNO. 43 (9): 552–5. PMID 7591868.
↑ Fisher, SC.; Horning, GM.; Hellstein, JW. (Dec 2001). "Myospherulosis complicating cortical block grafting: a case report". J Periodontol. 72 (12): 1755–9. doi:10.1902/jop.2001.72.12.1755. PMID 11811513.
↑ Chau, KY.; Pretorius, JM.; Stewart, AW. (Oct 2000). "Myospherulosis in renal cell carcinoma". Arch Pathol Lab Med. 124 (10): 1476–9. doi:10.5858/2000-124-1476-MIRCC. PMID 11035579.

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[pmid7591868-1] 1 2 3 Godbersen, GS.; Kleeberg, J.; Lüttges, J.; Werner, JA. (Sep 1995). "[Spherulocytosis (myospherulosis) of the paranasal sinuses]". HNO. 43 (9): 552–5. PMID 7591868.

[pmid11811513-2] Fisher, SC.; Horning, GM.; Hellstein, JW. (Dec 2001). "Myospherulosis complicating cortical block grafting: a case report". J Periodontol. 72 (12): 1755–9. doi:10.1902/jop.2001.72.12.1755. PMID 11811513.

[pmid11035579-3] Chau, KY.; Pretorius, JM.; Stewart, AW. (Oct 2000). "Myospherulosis in renal cell carcinoma". Arch Pathol Lab Med. 124 (10): 1476–9. doi:10.5858/2000-124-1476-MIRCC. PMID 11035579.

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[3]

Myospherulosis

See also

References