The PTS Galactitol (Gat) Family (TC# 4.A.5) is part of the PTS-AG superfamily. The biochemistry of this family is poorly defined. The only well-characterized member of this family is the galactitol permease of Escherichia coli. [1] However, a homologous IIC protein from Listeria monocytogenes has been shown to be required for D-arabitol fermentation. [2] It presumably functions together with IIAGat and IIBGat homologues. IICGat is distantly related to IICSgc of E. coli; IIAGat is distantly related to IIASga and IIASgcof E. coli as well as IIAMtl and IIAFru. IIBGat is distantly related to IIBSga and IIBSgc of E. coli. [3] Domains in the LicR/CelR family of transcriptional activators show C-terminal domains exhibiting weak sequence similarity to IIBGat and IIAGat. [4]
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