Palmitoleoylation

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In palmitoleoylation, a palmitoleoyl group (derived from palmitoleic acid, pictured above) is added. Palmitoleic acid.svg
In palmitoleoylation, a palmitoleoyl group (derived from palmitoleic acid, pictured above) is added.

Palmitoleoylation is type of protein lipidation where the monounsaturated fatty acid palmitoleic acid is covalently attached to serine or threonine residues of proteins. [1] [2] Palmitoleoylation appears to play a significant role in trafficking and targeting and function of Wnt proteins. [3] [4] [5]

O-Palmitoleoylation of Wnt proteins is catalysed by PORCN. The inverse reaction is done by NOTUM. [6]

References

  1. ↑ Hannoush, Rami N. (2015). "Synthetic protein lipidation". Current Opinion in Chemical Biology. 28: 39–46. doi:10.1016/j.cbpa.2015.05.025. ISSN   1879-0402. PMID   26080277.
  2. ↑ Pelegri F; Danilchik M; Sutherland A, eds. (2017). Vertebrate Development : Maternal to Zygotic Control. Advances in Experimental Medicine and Biology. Cham: Springer International Publishing. ISBN   9783319460956. OCLC   979974353.
  3. ↑ Hosseini, Vahid; Dani, Christian; Geranmayeh, Mohammad Hossein; Mohammadzadeh, Fatemeh; Nazari Soltan Ahmad, Saeed; Darabi, Masoud (2018-10-20). "Wnt lipidation: Roles in trafficking, modulation, and function". Journal of Cellular Physiology. 234 (6): 8040–8054. doi:10.1002/jcp.27570. ISSN   1097-4652. PMID   30341908.
  4. ↑ Nile, Aaron H.; Hannoush, Rami N. (February 2016). "Fatty acylation of Wnt proteins". Nature Chemical Biology. 12 (2): 60–69. doi:10.1038/nchembio.2005. ISSN   1552-4469. PMID   26784846.
  5. ↑ Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S (2006). "Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion". Dev Cell. 11 (6): 791–801. doi: 10.1016/j.devcel.2006.10.003 . PMID   17141155.
  6. ↑ Lanyon-Hogg, Thomas; Faronato, Monica; Serwa, Remigiusz A.; Tate, Edward W. (2017). "Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets". Trends in Biochemical Sciences. 42 (7): 566–581. doi:10.1016/j.tibs.2017.04.004. hdl: 10044/1/48121 . PMID   28602500.
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