Paul Breslin | |
---|---|
Alma mater | University of Pennsylvania |
Known for | Work with human oral perception and flies |
Scientific career | |
Fields | Psychology, Genetics |
Institutions | Monell Chemical Senses Center, Rutgers University |
Paul Breslin is a geneticist and biologist.
He is most notable for his work in taste perception and oral irritation, [1] in humans as well as in Drosophila melanogaster , the common fruit fly.
He is a member of the faculty at the Monell Chemical Senses Center and acts as director of the Science Apprenticeship Program. He is a professor in the Department of Nutritional Sciences at Rutgers, the State University of New Jersey. [2] Breslin and two colleaguesdiscovered that Oleocanthal, a compound found in extra-virgin olive oil kills a variety of human cancer cells without harming healthy cells. [3]
Food is any substance consumed by an organism for nutritional support. Food is usually of plant, animal, or fungal origin and contains essential nutrients such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism and assimilated by the organism's cells to provide energy, maintain life, or stimulate growth. Different species of animals have different feeding behaviours that satisfy the needs of their metabolisms and have evolved to fill a specific ecological niche within specific geographical contexts.
In nutrition, biology, and chemistry, fat usually means any ester of fatty acids, or a mixture of such compounds, most commonly those that occur in living beings or in food.
Olive oil is a liquid fat obtained by pressing whole olives, the fruit of Olea europaea, a traditional tree crop of the Mediterranean Basin, and extracting the oil.
Garlic is a species of bulbous flowering plant in the genus Allium. Its close relatives include the onion, shallot, leek, chive, Welsh onion, and Chinese onion. It is native to Central Asia, South Asia and northeastern Iran and has long been used as a seasoning worldwide, with a history of several thousand years of human consumption and use. It was known to ancient Egyptians and has been used as both a food flavoring and a traditional medicine. China produced 73% of the world's supply of garlic in 2021.
Umami, or savoriness, is one of the five basic tastes. It is characteristic of broths and cooked meats.
Saliva is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells, enzymes, and antimicrobial agents.
Phytochemicals are chemical compounds produced by plants, generally to help them resist fungi, bacteria and plant virus infections, and also consumption by insects and other animals. The name comes from Greek φυτόν (phyton) 'plant'. Some phytochemicals have been used as poisons and others as traditional medicine.
Supertasters are individuals whose sense of taste for certain flavors and foods, such as chocolate, is far more sensitive than the average person. The term originated with experimental psychologist Linda Bartoshuk and is not the result of response bias or a scaling artifact but appears to have an anatomical or biological basis.
Oleocanthal is a phenylethanoid, or a type of natural phenolic compound found in extra-virgin olive oil. It appears to be responsible for the burning sensation that occurs in the back of the throat when consuming such oil. Oleocanthal is a tyrosol ester and its chemical structure is related to oleuropein, also found in olive oil.
Thomas Eugene Shenk is an American virologist. He is currently Emeritus Professor of Life Sciences in the Department of Molecular Biology at Princeton University.
The Monell Chemical Senses Center is an independent, non-profit scientific research institute located at the University City Science Center campus in Philadelphia. Founded in 1968, it is dedicated to interdisciplinary basic research on the senses of taste and smell. The center's mission is to improve health and well-being by advancing the scientific understanding of taste, smell, and related senses. Monell's research focuses on various aspects of chemosensory science, including how chemical senses affect human health, behavior, and the environment. The center employs a collaborative and interdisciplinary approach, with scientists from diverse fields such as sensory psychology, biophysics, chemistry, behavioral neuroscience, environmental science, and genetics working together on research projects.
Chemesthesis is the detection of potentially harmful chemicals by the skin and mucous membranes. Chemesthetic sensations arise when chemical compounds activate receptors associated with other senses that mediate pain, touch, and thermal perception. These chemical-induced reactions do not fit into the traditional sense categories of taste and smell.
The Pennington Biomedical Research Center is a health science-focused research center in Baton Rouge, Louisiana. It is part of the Louisiana State University System and conducts clinical, basic, and population science research. It is the largest academically-based nutrition research center in the world, with the greatest number of obesity researchers on faculty. The center's over 500 employees occupy several buildings on the 222-acre (0.90 km2) campus. The center was designed by the Baton Rouge architect John Desmond.
A taste receptor or tastant is a type of cellular receptor that facilitates the sensation of taste. When food or other substances enter the mouth, molecules interact with saliva and are bound to taste receptors in the oral cavity and other locations. Molecules which give a sensation of taste are considered "sapid".
Maslinic acid is a compound derived from dry olive-pomace oil which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.
Dr. Gary K. Beauchamp was the director and president of the Monell Chemical Senses Center from August 1990 to September 2014.
The gustatory system or sense of taste is the sensory system that is partially responsible for the perception of taste (flavor). Taste is the perception stimulated when a substance in the mouth reacts chemically with taste receptor cells located on taste buds in the oral cavity, mostly on the tongue. Taste, along with the sense of smell and trigeminal nerve stimulation, determines flavors of food and other substances. Humans have taste receptors on taste buds and other areas, including the upper surface of the tongue and the epiglottis. The gustatory cortex is responsible for the perception of taste.
Masayoshi Yamaguchi is a biomedical scientist and researcher, most known for his contributions to biomedical fields including biochemistry, endocrinology, metabolism, nutrition, pharmacology, and toxicology. He is a full professor in the Cancer Biology Program at the University of Hawaii Cancer Center, University of Hawaii at Manoa (UH), focusing on research in bone and calcium endocrinology, metabolism, cell calcium signaling, gene regulation, dietary prevention of osteoporosis, carcinogenesis, and cancer therapy.
Christina Athena Aktipis is an associate professor in the department of psychology at Arizona State University. She is the director of the Interdisciplinary Cooperation Initiative and the co-director of the Human Generosity Project. She is also the director of the Cooperation and Conflict lab at Arizona State, vice president of the International Society for Evolution, Ecology and Cancer (ISEEC), and former director of human and social evolution and co-founder of the Center for Evolution and Cancer at UCSF. She is a cooperation theorist, an evolutionary biologist, an evolutionary psychologist, and a cancer biologist who works at the intersection of those fields. Aktipis is the author of the books The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer (2020) and A Field Guide to the Apocalypse: A Mostly Serious Guide to Surviving Our Wild Times (2024). She hosts Zombified, a podcast that discusses the science of zombification in daily life. The podcast is an extension of the Zombie Apocalypse Medicine Meeting (ZAMM), a biannual conference chaired by Aktipis. ZAMM is an interdisciplinary conference where art, science, and medicine come together with the aim of solving complex issues.
Trans fat, also called trans-unsaturated fatty acids, or trans fatty acids, is a type of unsaturated fat that occurs in foods. Trace concentrations of trans fats occur naturally, but large amounts are found in some processed foods. Since consumption of trans fats is unhealthy, artificial trans fats are highly regulated or banned in many nations. However, they are still widely consumed in developing nations, resulting in hundreds of thousands of deaths each year. The World Health Organization (WHO) had set a goal to make the world free from industrially produced trans fat by the end of 2023. The goal was not met, and the WHO announced another goal "for accelerated action till 2025 to complete this effort" along with associated support on 1 February 2024.