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A model lipid bilayer is any bilayer assembled in vitro, as opposed to the bilayer of natural cell membranes or covering various sub-cellular structures like the nucleus. They are used to study the fundamental properties of biological membranes in a simplified and well-controlled environment, and increasingly in bottom-up synthetic biology for the construction of artificial cells. A model bilayer can be made with either synthetic or natural lipids. The simplest model systems contain only a single pure synthetic lipid. More physiologically relevant model bilayers can be made with mixtures of several synthetic or natural lipids.
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References
- 1 2 "King's College London - Head of Department". www.kcl.ac.uk. Retrieved 9 February 2019.
- 1 2 "List of Philip Leverhulme prize winners" (PDF).
- 1 2 "Paula Booth | Royal Society". royalsociety.org. Retrieved 9 February 2019.
- 1 2 "List of ERC Advanced grants 2011" (PDF).
- ↑ "The London Centre for Nanotechnology".
- ↑ Meijberg, Wim; Booth, Paula J. (7 June 2002). "The Activation Energy for Insertion of Transmembrane α-Helices is Dependent on Membrane Composition". Journal of Molecular Biology. 319 (3): 839–853. doi:10.1016/S0022-2836(02)00342-X. ISSN 0022-2836. PMID 12054874.
- 1 2 Bristol, University of. "2003: Innovative, high-risk research | News | University of Bristol". www.bristol.ac.uk. Retrieved 9 February 2019.
- ↑ Booth, Paula J.; Findlay, Heather E.; Charalambous, Kalypso; Harris, Nicola J. (19 October 2018). "Lipids modulate the insertion and folding of the nascent chains of alpha helical membrane proteins". Biochemical Society Transactions. 46 (5): 1355–1366. doi:10.1042/BST20170424. ISSN 0300-5127. PMID 30190329.
- ↑ Fletcher, Jordan M.; Boyle, Aimee L.; Bruning, Marc; Bartlett, Gail J.; Vincent, Thomas L.; Zaccai, Nathan R.; Armstrong, Craig T.; Bromley, Elizabeth H. C.; Booth, Paula J. (15 June 2012). "A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology". ACS Synthetic Biology. 1 (6): 240–250. doi:10.1021/sb300028q. hdl: 1887/45977 . PMID 23651206.
- ↑ Simms, John; Booth, Paula J (1 December 2013). "Membrane proteins by accident or design". Current Opinion in Chemical Biology. Synthetic biology • Synthetic biomolecules. 17 (6): 976–981. doi:10.1016/j.cbpa.2013.10.005. ISSN 1367-5931. PMID 24466578.
- ↑ Martens, Chloe; Shekhar, Mrinal; Borysik, Antoni J.; Lau, Andy M.; Reading, Eamonn; Tajkhorshid, Emad; Booth, Paula J.; Politis, Argyris (8 October 2018). "Direct protein-lipid interactions shape the conformational landscape of secondary transporters". Nature Communications. 9 (1): 4151. doi:10.1038/s41467-018-06704-1. ISSN 2041-1723. PMC 6175955 . PMID 30297844.
- ↑ Hellwig, Nils; Peetz, Oliver; Ahdash, Zainab; Tascón, Igor; Booth, Paula J.; Mikusevic, Vedrana; Diskowski, Marina; Politis, Argyris; Hellmich, Yvonne (18 December 2018). "Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs". Chemical Communications (Cambridge, England). 54 (97): 13702–13705. doi:10.1039/c8cc06284f. ISSN 1359-7345. PMC 6289172 . PMID 30452022.
- ↑ Bristol, University of. "2008: RS Wolfson Awards | News | University of Bristol". www.bristol.ac.uk. Retrieved 9 February 2019.
- ↑ "Prof. Paula Booth - AcademiaNet". www.academia-net.org. Retrieved 9 February 2019.
