Paula Booth

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Paula Booth
Born
Paula Jane Booth
NationalityEnglish
Known forStudy of Lipids and Membranes
AwardsPhilip Leverhulme Prize
Scientific career
FieldsChemistry and Biochemistry
InstitutionsKing's College, London

Paula Jane Booth is an English chemist who holds the Daniell Chair of Chemistry at King's College London and is Head of Department. [1] Booth was awarded a Philip Leverhulme Prize in 2003, a Royal Society Wolfson Research Merit Award in 2008 and an ERC Advanced grant in 2012 for her novel work on investigating the mechanisms of biological self-assembly. [2] [3] [4]

Contents

Education and academic career

Booth studied for a BA Hons in Chemistry at St John’s College, Oxford. Booth undertook a PhD to study the thermodynamic properties of electron transfer in Photosystem 2 reaction centres, at Imperial College, London, under the supervisor of George Porter and James Barber. Following a short fellowship at the Centre D-Etudes de Saclay outside Paris, Booth set up her own research group at the University of Oxford, whilst holding a Research Fellowship at Corpus Christi College. After this, Booth moved to Imperial College and then the University of Bristol where she was appointed professor in 2005. In 2014 Booth was appointed Daniell Chair and Head of Department at King's College London. [1] She is also on the academic staff at The London Centre for Nanotechnology. [5]

Research interests

At the University of Bristol, Booth investigated the minimal lipid composition which allows insertion of membrane proteins. [6] [7] Booth's current research studies how membrane lipids impact on membrane protein folding and activity. [8] Booth also investigates the design of artificial membrane proteins and lipids to develop synthetic biology systems to apply to useful applications. [9] [10] Techniques from many disciplines are put to use by Booth to measure and alter properties of membrane lipids and proteins. [11] [12]

Professional associations and awards

References

  1. 1 2 "King's College London - Head of Department". www.kcl.ac.uk. Retrieved 9 February 2019.
  2. 1 2 "List of Philip Leverhulme prize winners" (PDF).
  3. 1 2 "Paula Booth | Royal Society". royalsociety.org. Retrieved 9 February 2019.
  4. 1 2 "List of ERC Advanced grants 2011" (PDF).
  5. ↑ "The London Centre for Nanotechnology".
  6. ↑ Meijberg, Wim; Booth, Paula J. (7 June 2002). "The Activation Energy for Insertion of Transmembrane α-Helices is Dependent on Membrane Composition". Journal of Molecular Biology. 319 (3): 839–853. doi:10.1016/S0022-2836(02)00342-X. ISSN   0022-2836. PMID   12054874.
  7. 1 2 Bristol, University of. "2003: Innovative, high-risk research | News | University of Bristol". www.bristol.ac.uk. Retrieved 9 February 2019.
  8. ↑ Booth, Paula J.; Findlay, Heather E.; Charalambous, Kalypso; Harris, Nicola J. (19 October 2018). "Lipids modulate the insertion and folding of the nascent chains of alpha helical membrane proteins". Biochemical Society Transactions. 46 (5): 1355–1366. doi:10.1042/BST20170424. ISSN   0300-5127. PMID   30190329. S2CID   52168815.
  9. ↑ Fletcher, Jordan M.; Boyle, Aimee L.; Bruning, Marc; Bartlett, Gail J.; Vincent, Thomas L.; Zaccai, Nathan R.; Armstrong, Craig T.; Bromley, Elizabeth H. C.; Booth, Paula J. (15 June 2012). "A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology". ACS Synthetic Biology. 1 (6): 240–250. doi:10.1021/sb300028q. hdl: 1887/45977 . PMID   23651206.
  10. ↑ Simms, John; Booth, Paula J (1 December 2013). "Membrane proteins by accident or design". Current Opinion in Chemical Biology. Synthetic biology • Synthetic biomolecules. 17 (6): 976–981. doi:10.1016/j.cbpa.2013.10.005. ISSN   1367-5931. PMID   24466578.
  11. ↑ Martens, Chloe; Shekhar, Mrinal; Borysik, Antoni J.; Lau, Andy M.; Reading, Eamonn; Tajkhorshid, Emad; Booth, Paula J.; Politis, Argyris (8 October 2018). "Direct protein-lipid interactions shape the conformational landscape of secondary transporters". Nature Communications. 9 (1): 4151. Bibcode:2018NatCo...9.4151M. doi:10.1038/s41467-018-06704-1. ISSN   2041-1723. PMC   6175955 . PMID   30297844.
  12. ↑ Hellwig, Nils; Peetz, Oliver; Ahdash, Zainab; Tascón, Igor; Booth, Paula J.; Mikusevic, Vedrana; Diskowski, Marina; Politis, Argyris; Hellmich, Yvonne (18 December 2018). "Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs". Chemical Communications. 54 (97): 13702–13705. doi:10.1039/c8cc06284f. ISSN   1359-7345. PMC   6289172 . PMID   30452022.
  13. ↑ Bristol, University of. "2008: RS Wolfson Awards | News | University of Bristol". www.bristol.ac.uk. Retrieved 9 February 2019.
  14. ↑ "Prof. Paula Booth - AcademiaNet". www.academia-net.org. Retrieved 9 February 2019.
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