Periodontal ligament stem cells

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Periodontal ligament stem cells or periodontal membrane stem cells are stem cells found near the periodontal ligament of the teeth. These cells have shown potential in the regeneration of not only the periodontal complex but also other dental and non-dental tissues. [1] [2] [3] They are involved in adult regeneration of the periodontal ligament, alveolar bone, and cementum. The cells are known to express STRO-1 and CD146 proteins. [4]

Periodontal ligament stem cells play a role as progenitor cells. [5] They are capable of generating into osteoblasts, cementoblasts, chondrocytes, and adipocytes.

References

  1. ↑ Seo, Byoung-Moo; Miura, Masako; Gronthos, Stan; Mark Bartold, Peter; Batouli, Sara; Brahim, Jaime; Young, Marian; Gehron Robey, Pamela; Wang, Cun Yu; Shi, Songtao (July 2004). "Investigation of multipotent postnatal stem cells from human periodontal ligament" . The Lancet. 364 (9429): 149–155. doi:10.1016/S0140-6736(04)16627-0.
  2. ↑ Yang, Y.; Alves, T.; Miao, M.Z.; Wu, Y.C.; Li, G.; Lou, J.; Hasturk, H.; Van Dyke, T.E.; Kantarci, A.; Wu, D. (January 2024). "Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells". Journal of Dental Research. 103 (1): 71–80. doi:10.1177/00220345231205283. ISSN   0022-0345. PMC   10850875 . PMID   37982164.
  3. ↑ Queiroz, Aline; Albuquerque-Souza, Emmanuel; Gasparoni, Leticia Miquelitto; França, Bruno Nunes de; Pelissari, Cibele; Trierveiler, Marília; Holzhausen, Marinella (2021-06-26). "Therapeutic potential of periodontal ligament stem cells". World Journal of Stem Cells. 13 (6): 605–618. doi: 10.4252/wjsc.v13.i6.605 . ISSN   1948-0210. PMC   8246246 .
  4. ↑ Alves, Tomaz; Gasparoni, Letícia M.; Balzarini, Danilo; Albuquerque-Souza, Emmanuel; de Oliveira, Victhor; Rovai, Emanuel S.; da Silva, Jose; Huamán-Mendoza, Aldrin; Catalani, Luiz H.; Sipert, Carla R.; Holzhausen, Marinella (2022-09-18). "Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PAR1) in vivo". Scientific Reports. 12 (1). doi:10.1038/s41598-022-19520-x. ISSN   2045-2322. PMC   9482923 . PMID   36117187.
  5. ↑ Han, J; Menicanin, D; Gronthos, S; Bartold, PM (2013-09-23). "Stem cells, tissue engineering and periodontal regeneration" . Australian Dental Journal. 59 (s1): 117–130. doi: 10.1111/adj.12100 . ISSN   0045-0421.


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