Peripolesis

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Peripolesis is the process in which a cell attaches itself to another cell. This is differentiated from emperipolesis , which is when one cell is engulfed by another.

Peripolesis is thought to be a physiological mechanism involved in regulating some processes of immune response. It was observed between lymphocytes and macrophages following skin grafts between subjects, and after immune challenge with antigens. [1] Peripolesis was also observed in lung alveoli, where the peripolesed macrophages were not injured, but the cell membrane did appear to be temporarily altered. [2] In patients with active sarcoidosis, which is characterized by lymphocyte-macrophage cooperation, lymphocyte peripolesis appeared to occur in clusters and could last for minutes to hours. The lymphocytes could be seen moving around a macrophage while maintaining contact. [3]

References

  1. ↑ Sharp, J. A.; Burwell, R. G. (1960-11-05). "Interaction ('Peripolesis') of Macrophages and Lymphocytes after Skin Homografting or Challenge with Soluble Antigens". Nature. 188 (4749): 474–475. doi:10.1038/188474a0. S2CID   4144908.
  2. ↑ Lyons DJ, Gautam A, Clark J, Harries MG, Mitchell EB, Milledge JS, Balfour BM (Jan 1992). "Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages". European Respiratory Journal. 5 (1): 59–66. PMID   1577151.
  3. ↑ van Maarsseveen, Ton C.; de Groot, Jan; Stam, Jaap; van Diest, Paul J. (1993-05-01). "Peripolesis in Alveolar Sarcoidosis". American Review of Respiratory Disease. 147 (5): 1259–1263. doi:10.1164/ajrccm/147.5.1259. ISSN   0003-0805. PMID   8484640.
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