Personalized mRNA cancer vaccine therapy

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Personalized mRNA cancer vaccine therapy is a therapy that uses a personalized cancer vaccine based on mRNA vaccine technology to target existing tumors in patients. As of 2024, number of mRNA cancer vaccines are in clinical trials, of which many are personalized therapies based on engineering mRNA-mediated immune response that targets the patient's particular strain of cancer cells. [1]

Experimental treatments include treatments for pancreatic cancer, head and neck cancers, and melanoma. [2] [3] [4]

In 2024, the British National Health Service announced that had launched its Cancer Vaccine Launch Pad, a collaboration for trials for the use of personalized mRNA cancer vaccines on its patients. [5]

References

  1. ↑ Yao, Ruhui; Xie, Chunyuan; Xia, Xiaojun (2024-12-31). "Recent progress in mRNA cancer vaccines". Human Vaccines & Immunotherapeutics. 20 (1). doi:10.1080/21645515.2024.2307187. ISSN   2164-5515. PMC   10826636 . PMID   38282471.
  2. ↑ Kang, Ning; Zhang, Si; Wang, Yuzhuo (2023). "A personalized mRNA vaccine has exhibited potential in the treatment of pancreatic cancer". Holistic Integrative Oncology. 2 (1): 18. doi:10.1007/s44178-023-00042-z. ISSN   2731-4529. PMC   10248956 . PMID   37323470.
  3. ↑ Shibata, Hirofumi; Zhou, Liye; Xu, Na; Egloff, Ann Marie; Uppaluri, Ravindra (March 2021). "Personalized cancer vaccination in head and neck cancer". Cancer Science. 112 (3): 978–988. doi:10.1111/cas.14784. ISSN   1349-7006. PMC   7935792 . PMID   33368875.
  4. ↑ Carvalho, Thiago (2023-08-16). "Personalized anti-cancer vaccine combining mRNA and immunotherapy tested in melanoma trial" . Nature Medicine. 29 (10): 2379–2380. doi:10.1038/d41591-023-00072-0. PMID   37773210.
  5. ↑ Walsh, Fergus (2024-05-30). "Thousands to trial personalised cancer vaccines". BBC News. Retrieved 2024-06-01.


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