Related Research Articles
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum. Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, abdominal pain and fatigue. Most colorectal cancers are due to lifestyle factors and genetic disorders. Risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.
Genetic counseling is the process of investigating individuals and families affected by or at risk of genetic disorders to help them understand and adapt to the medical, psychological and familial implications of genetic contributions to disease. This field is considered necessary for the implementation of genomic medicine. The process integrates:
Li–Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary disorder that predisposes carriers to cancer development. It was named after two American physicians, Frederick Pei Li and Joseph F. Fraumeni Jr., who first recognized the syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients. The disease is also known as SBLA, for the Sarcoma, Breast, Leukemia, and Adrenal Gland cancers that it is known to cause.
In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. The chief advantage of proton therapy over other types of external beam radiotherapy is that the dose of protons is deposited over a narrow range of depth; hence in minimal entry, exit, or scattered radiation dose to healthy nearby tissues.
A cancer survivor is a person with cancer of any type who is still living. Whether a person becomes a survivor at the time of diagnosis or after completing treatment, whether people who are actively dying are considered survivors, and whether healthy friends and family members of the cancer patient are also considered survivors, varies from group to group. Some people who have been diagnosed with cancer reject the term survivor or disagree with some definitions of it.
Psycho-oncology is an interdisciplinary field at the intersection of physical, psychological, social, and behavioral aspects of the cancer experience for both patients and caregivers. Also known as psychiatric oncology or psychosocial oncology, researchers and practitioners in the field are concerned with aspects of individuals' experience with cancer beyond medical treatment, and across the cancer trajectory, including at diagnosis, during treatment, transitioning to and throughout survivorship, and approaching the end-of-life. Founded by Jimmie Holland in 1977 via the incorporation of a psychiatric service within the Memorial Sloan Kettering Cancer Center in New York, the field has expanded drastically since and is now universally recognized as an integral component of quality cancer care. Cancer centers in major academic medical centers across the country now uniformly incorporate a psycho-oncology service into their clinical care, and provide infrastructure to support research efforts to advance knowledge in the field.
Tegafur/uracil is a chemotherapy drug combination used in the treatment of cancer, primarily bowel cancer.
TOX high mobility group box family member 3, also known as TOX3, is a human gene.
In psychology, posttraumatic growth (PTG) is positive psychological change experienced as a result of struggling with highly challenging, highly stressful life circumstances. These circumstances represent significant challenges to the adaptive resources of the individual, and pose significant challenges to the individual's way of understanding the world and their place in it. Posttraumatic growth involves "life-changing" psychological shifts in thinking and relating to the world and the self, that contribute to a personal process of change, that is deeply meaningful.
Hydrazine sulfate, more properly hydrazinium hydrogensulfate, is a salt of the cation hydrazinium and the anion bisulfate (hydrogensulfate), with the formula N2H6SO4 or more properly [N2H5]+[HSO4]−. It is a white, water-soluble solid at room temperature.
Anil Potti is a physician and former Duke University associate professor and cancer researcher, focusing on oncogenomics. He, along with Joseph Nevins, are at the center of a research fabrication scandal at Duke University. On 9 November 2015, the Office of Research Integrity (ORI) found that Potti had engaged in research misconduct. According to Potti's voluntary settlement agreement with ORI, Potti can continue to perform research with the requirement of supervision until year 2020, while he "neither admits nor denies ORI's findings of research misconduct." As of 2024 Potti, who is employed at the Cancer Center of North Dakota, has had 11 of his research publications retracted, one publication has received an expression of concern, and two others have been corrected.
A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer. Genetic, epigenetic, proteomic, glycomic, and imaging biomarkers can be used for cancer diagnosis, prognosis, and epidemiology. Ideally, such biomarkers can be assayed in non-invasively collected biofluids like blood or serum.
High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant, was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. With an overall idea that more is better, this process involved taking cells from the person's bone marrow to store in a lab, then to give such high doses of chemotherapy drugs that the remaining bone marrow was destroyed, and then to inject the cells taken earlier back into the body as replacement. It was ultimately determined to be no more effective than normal treatment, and to have significantly higher side effects, including treatment-related death.
Lorenzo Cohen is a professor in the Department of General Oncology and Behavioral Science and the director of the Integrative Medicine Program at the University of Texas MD Anderson Cancer Center. He is also a distinguished clinical professor at the Fudan University Shanghai Cancer Center in Shanghai, China. Cohen is a founding member and past president of the Society for Integrative Oncology.
Professor Dame Lesley Jean Fallowfield DBE is a British cancer psychologist and a professor of psycho-oncology at the University of Sussex. The main outcomes of her research have been the establishment of assessment tools to measure quality of life in clinical trials of cancer patients and the design of educational programmes to improve oncologists' communication with their patients.
Suzanne Kathleen Chambers, is a Professor and Dean of the Faculty of Health at Sydney's University of Technology. She specialises in psycho-oncology, and has received Queen's Birthday honours. Chambers has worked on psycho-oncology, prostate cancer, health economics and psychological interventions including the distress and adjustments after cancer.
Georgina Venetia Long is an Australian medical oncologist, clinical trialist and translational researcher, and works in drug therapy development. Long was the first woman and first Australian to be named president of the US-based Society for Melanoma Research.
Bisantrene is an anthracenyl bishydrazone with anthracycline-like antineoplastic activity and an antimetabolite. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in chemotherapeutic activity, but unlike anthracyclines like doxorubicin, it exhibits little cardiotoxicity.
Xavier Pivot is a French oncologist, university professor, breast cancer specialist and general director of the Strasbourg Cancer Institute. He is best known for his research on treatments with trastuzumab in HER2-positive breast cancers.
Psychosocial distress refers to the unpleasant emotions or psychological symptoms an individual has when they are overwhelmed, which negatively impacts their quality of life. Psychosocial distress is most commonly used in medical care to refer to the emotional distress experienced by populations of patients and caregivers of patients with complex chronic conditions such as cancer, diabetes, and cardiovascular conditions, which confer heavy symptom burdens that are often overwhelming, due to the disease's association with death. Due to the significant history of psychosocial distress in cancer treatment, and a lack of reliable secondary resources documenting distress in other contexts, psychosocial distress will be mainly discussed in the context of oncology.
References
- 1 2 3 4 5 6 7 8 9 "Staff Profile". The University of Sydney. Retrieved 2024-07-24.
- ↑ "Phyllis Butow". 2024 COSA ASM. Retrieved 2024-07-24.
- ↑ "Prof Phyllis Butow". Head & Neck Cancer. Retrieved 2024-07-24.
- 1 2 "Professor Phyllis Butow". Research Data Australia. Retrieved 2024-07-24.
- ↑ "PoCoG". PoCoG. Retrieved 2024-07-24.
- ↑ Smith, Allan ‘Ben’; King, Madeleine; Butow, Phyllis; Luckett, Tim; Grimison, Peter; Toner, Guy C.; Stockler, Martin; Hovey, Elizabeth; Stubbs, John; Hruby, George; Gurney, Howard; Turner, Sandra; Alam, Mahmood; Cox, Keith; Olver, Ian (2013-07-03). "The prevalence and correlates of supportive care needs in testicular cancer survivors: a cross-sectional study". Psycho-Oncology. 22 (11): 2557–2564. doi:10.1002/pon.3323. ISSN 1057-9249. PMID 23825010.
- ↑ "Phyllis Butow". scholar.google.com. Retrieved 2024-07-24.
- ↑ Easton, Douglas F.; Pooley, Karen A.; Dunning, Alison M.; Pharoah, Paul D. P.; Thompson, Deborah; Ballinger, Dennis G.; Struewing, Jeffery P.; Morrison, Jonathan; Field, Helen; Luben, Robert; Wareham, Nicholas; Ahmed, Shahana; Healey, Catherine S.; Bowman, Richard; Meyer, Kerstin B. (2007). "Genome-wide association study identifies novel breast cancer susceptibility loci". Nature. 447 (7148): 1087–1093. Bibcode:2007Natur.447.1087E. doi:10.1038/nature05887. ISSN 1476-4687. PMC 2714974 . PMID 17529967.
- ↑ Butow, P. N.; Maclean, M.; Dunn, S. M.; Tattersall, M. H. N.; Boyer, M. J. (1997-08-01). "The dynamics of change: Cancer patients' preferences for information, involvement and support". Annals of Oncology. 8 (9): 857–863. doi:10.1023/A:1008284006045. ISSN 0923-7534. PMID 9358935.
- ↑ Individual Determinants of Health and Human Behavior (Custom ed.).
- ↑ "Health psychology" (PDF).
- ↑ "P-OMICs-flow: Integrating precision oncology into clinical programs". Macquarie University. Retrieved 2024-07-24.
- ↑ Beatty, Lisa; Kemp, Emma; Butow, Phyllis; Girgis, Afaf; Hulbert-Williams, Nicholas; Kaambwa, Billingsley; Schofield, Penelope; Turner, Jane; Woodman, Richard; Boyle, Frances; Daly, Anthony; Jones, Amanda; Kiely, Belinda; Zdenkowski, Nicholas; Koczwara, Bogda (2022-12-24). "Finding My Way-Advanced: can a web-based psychosocial intervention improve the mental quality of life for women with metastatic breast cancer vs attention-control? Study protocol of a randomised controlled trial". BMC Cancer. 22 (1): 1353. doi: 10.1186/s12885-022-10410-z . ISSN 1471-2407. PMC 9789659 . PMID 36566189.
- ↑ Ben Bouchta, Youssef; Gardner, Mark; Sengupta, Chandrima; Johnson, Julia; Keall, Paul (2024-01-29). "The Remove-the-Mask Open-Source head and neck Surface-Guided radiation therapy system". Physics and Imaging in Radiation Oncology. 29: 100541. doi:10.1016/j.phro.2024.100541. ISSN 2405-6316. PMC 10847032 . PMID 38327762.
| International | |
|---|---|
| National | |
| Academics | |
| People | |
