Polar T3 syndrome

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Polar T3 syndrome is a condition found in polar explorers, caused by a decrease in levels of the thyroid hormone T3. [1] [2] Its effects include forgetfulness, cognitive impairment and mood disturbances. It can exhibit itself in a fugue state known as the Antarctic stare. [3] [4] [5]

Effects of polar environment conditions (long time coldness [6] or bioactive factors [7] ) are proposed as hypothetical causes of this syndrome.

It is regarded as one of the contributory causes of winter-over syndrome. [3]

See also

References

  1. ↑ Reed HL, Silverman ED, Shakir KM, Dons R, Burman KD, O'Brian JT (April 1990). "Changes in serum triiodothyronine (T3) kinetics after prolonged Antarctic residence: the polar T3 syndrome". The Journal of Clinical Endocrinology and Metabolism. 70 (4): 965–974. doi:10.1210/jcem-70-4-965. PMID   2318952.
  2. ↑ Palinkas LA, Suedfeld P (January 2008). "Psychological effects of polar expeditions". Lancet. 371 (9607): 153–163. doi:10.1016/S0140-6736(07)61056-3. PMID   17655924. S2CID   9601133.
  3. 1 2 Palinkas LA, Reed HL, Do NV (1997). "Association between the Polar T3 Syndrome and the Winter-Over Syndrome in Antarctica". Antarctic Journal of the United States Review 1997. Retrieved 2011-11-04.
  4. ↑ Emily Stone (November 9, 2004). "Treating the Antarctic blues".
  5. ↑ "Polar T3 Disorder". Natural History Museum. 17 April 2008.
  6. ↑ Nikanorova, Alena; Barashkov, Nikolay; Pshennikova, Vera; Teryutin, Fedor; Nakhodkin, Sergey; Solovyev, Aisen; Romanov, Georgii; Burtseva, Tatiana; Fedorova, Sardana (2023-09-13). "A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?". International Journal of Molecular Sciences. 24 (18): 14052. doi: 10.3390/ijms241814052 . ISSN   1422-0067. PMC   10531421 . PMID   37762355.
  7. ↑ Besharati, Mohammad Reza; Izadi, Mohammad; Talebpour, Alireza; Jafari, Nafiseh (2025-05-06), A Hypothesis on the Etiology of Polar T3 Syndrome and Related Polar Syndromes: The Role of Atmospheric /Oceanic Iodine in Human Hormonal Cycles in Polar Regions, doi:10.5281/ZENODO.15347489 , retrieved 2025-05-15


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