Powdered corn cob (PCC) is a rodenticide, marketed as a natural and environmentally-friendly alternative to anticoagulant types. The preparation was approved in July 2013 under the European Biocide Directive Program (Annex 1/1A BPD 98/8EEC). It works by causing acute and ultimately lethal dehydration.
Formulated and manufactured by Zea Sciences [1] over 15 years, PCC was granted EU under the European Biocide Directive Program, known as Annex 1/1A BPD 98/8EEC, in July 2013. [2] [3] The patent covers the principle of using any suitable natural dehydrant to kill rodents. [4]
"Cellulose from powdered corn cob" is proposed for approval in Canada in 2007. [5]
In 2005, the US Environmental Protection Agency (EPA) issued a warning letter regarding the sale of corn cob rodenticide with a misrepresented ingredient list. [6] In 2012, the EPA received a pesticide application for "cellulose" for the "Rode-Trol" rodenticide. [7] In 2022, the EPA received a pesticide application for "cellulose from corn cob". [8]
Similar to other rodenticides, the preparation requires 3–7 days to be effective. Rather than killing rodents through internal haemorrhaging as anticoagulants do, [9] PCC affects a rodent’s digestive system, causing acute dehydration due to its extremely absorptive nature (corn cob has been used in applications such as oil spills in water bodies, seed drying and de-icing). [10] Physiological digestive pathways are disrupted, preventing normal regulation of water and salt levels, leading to hypovolemic circulatory shock through reduced blood volume and blood pressure, oxygen deprivation of the blood, and ultimately death. [11]
It is by nature biodegradable, thus not an environmental pollutant. It poses no risk of contamination to crops, nor to the food chain. There is little threat of toxicity to children, pets, livestock or birds—including through secondary poisoning. [12] [13]
Pesticides are substances that are used to control pests. They include herbicides, insecticides, nematicides, fungicides, and many others. The most common of these are herbicides, which account for approximately 50% of all pesticide use globally. Most pesticides are used as plant protection products, which in general protect plants from weeds, fungi, or insects. In general, a pesticide is a chemical or biological agent that deters, incapacitates, kills, or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, molluscs, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, or spread disease, or are disease vectors. Along with these benefits, pesticides also have drawbacks, such as potential toxicity to humans and other species.
A biocide is defined in the European legislation as a chemical substance or microorganism intended to destroy, deter, render harmless, or exert a controlling effect on any harmful organism. The US Environmental Protection Agency (EPA) uses a slightly different definition for biocides as "a diverse group of poisonous substances including preservatives, insecticides, disinfectants, and pesticides used for the control of organisms that are harmful to human or animal health or that cause damage to natural or manufactured products". When compared, the two definitions roughly imply the same, although the US EPA definition includes plant protection products and some veterinary medicines.
Methylisothiazolinone, MIT, or MI, is the organic compound with the formula S(CH)2C(O)NCH3. It is a white solid. Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications. MIT and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis.
Pest control is the regulation or management of a species defined as a pest; such as any animal, plant or fungus that impacts adversely on human activities or environment. The human response depends on the importance of the damage done and will range from tolerance, through deterrence and management, to attempts to completely eradicate the pest. Pest control measures may be performed as part of an integrated pest management strategy.
Rodenticides are chemicals made and sold for the purpose of killing rodents. While commonly referred to as "rat poison", rodenticides are also used to kill mice, woodchucks, chipmunks, porcupines, nutria, beavers, and voles. Despite the crucial roles that rodents play in nature, there are times when they need to be controlled.
A corncob, also called corn cob, cob of corn, or corn on the cob, is the central core of an ear of maize. It is the part of the ear on which the kernels grow. The ear is also considered a "cob" or "pole" but it is not fully a "pole" until the ear is shucked, or removed from the plant material around the ear. It is also the green husk that goes outside the corn.
Atrazine is a chlorinated herbicide of the triazine class. It is used to prevent pre-emergence broadleaf weeds in crops such as maize (corn), soybean and sugarcane and on turf, such as golf courses and residential lawns. Atrazine's primary manufacturer is Syngenta and it is one of the most widely used herbicides in the United States, Canadian, and Australian agriculture. Its use was banned in the European Union in 2004, when the EU found groundwater levels exceeding the limits set by regulators, and Syngenta could not show that this could be prevented nor that these levels were safe.
The Principles of Good Laboratory Practice (GLP) are guidelines for managing non-clinical health and environmental studies effectively. They cover how studies are planned, conducted, recorded, and reported. These principles define roles and responsibilities within test facilities, set standards for facilities and equipment, emphasize the use of standard procedures, and require proper documentation and record-keeping. Overall, GLP ensures studies are conducted responsibly and produce reliable results for regulatory purposes globally.
Endrin is an organochlorine compound with the chemical formula C12H8Cl6O that was first produced in 1950 by Shell and Velsicol Chemical Corporation. It was primarily used as an insecticide, as well as a rodenticide and piscicide. It is a colourless, odorless solid, although commercial samples are often off-white. Endrin was manufactured as an emulsifiable solution known commercially as Endrex. The compound became infamous as a persistent organic pollutant and for this reason it is banned in many countries.
Aluminium phosphide is a highly toxic inorganic compound with the chemical formula AlP, used as a wide band gap semiconductor and a fumigant. This colorless solid is generally sold as a grey-green-yellow powder due to the presence of impurities arising from hydrolysis and oxidation.
Zinc phosphide (Zn3P2) is an inorganic chemical compound. It is a grey solid, although commercial samples are often dark or even black. It is used as a rodenticide. Zn3P2 is a II-V semiconductor with a direct band gap of 1.5 eV and may have applications in photovoltaic cells. A second compound exists in the zinc-phosphorus system, zinc diphosphide (ZnP2).
Corn gluten meal (CGM) is the principal protein of corn (maize) endosperm consisting mainly of zein and glutelin. It is a byproduct of corn processing that has historically been used as an animal feed. Despite the name, corn gluten does not contain true gluten, which is formed by the interaction of gliadin and glutenin proteins.
The Food Quality Protection Act (FQPA), or H.R.1627, was passed unanimously by Congress in 1996 and was signed into law by President Bill Clinton on August 3, 1996. The FQPA standardized the way the Environmental Protection Agency (EPA) would manage the use of pesticides and amended the Federal Insecticide, Fungicide, and Rodenticide Act and the Federal Food Drug and Cosmetic Act. It mandated a health-based standard for pesticides used in foods, provided special protections for babies and infants, streamlined the approval of safe pesticides, established incentives for the creation of safer pesticides, and required that pesticide registrations remain current.
Clothianidin is an insecticide developed by Takeda Chemical Industries and Bayer AG. Similar to thiamethoxam and imidacloprid, it is a neonicotinoid. Neonicotinoids are a class of insecticides that are chemically similar to nicotine, which has been used as a pesticide since the late 1700s. Clothianidin and other neonicotinoids act on the central nervous system of insects as an agonist of nAChR, the same receptor as acetylcholine, the neurotransmitter that stimulates and activating post-synaptic acetylcholine receptors but not inhibiting AChE. Clothianidin and other neonicotinoids were developed to last longer than nicotine, which is more toxic and which breaks down too quickly in the environment.
The indirect land use change impacts of biofuels, also known as ILUC or iLUC, relates to the unintended consequence of releasing more carbon emissions due to land-use changes around the world induced by the expansion of croplands for ethanol or biodiesel production in response to the increased global demand for biofuels.
The California Department of Pesticide Regulation, also known as DPR or CDPR, is one of six boards and departments of the California Environmental Protection Agency (Cal/EPA).
The Biocidal Products Directive (BPD) also known as the Biocides Directive is European Union Directive, (98/8/EC), which concerns biocides. It is officially known as Directive 98/8/EC of the European Parliament and of the Council of 16 February 1998 concerning the placing of biocidal products on the market. In 2013 the Biocidal Products Directive was superseded by The Biocidal Products Regulation.
d-CON is a brand of rodent control products, which is distributed and owned in the United States by the UK-based consumer goods company Reckitt.
Cyproconazole is an agricultural fungicide of the class of azoles, used on cereal crops, coffee, sugar beet, fruit trees and grapes, and peanuts, on sod farms and golf course turf and on wood as a preservative. It has been used against powdery mildew, rust on cereals and apple scab, and applied by air or on the ground or by chemigation.
A pesticide, also called Plant Protection Product (PPP), which is a term used in regulatory documents, consists of several different components. The active ingredient in a pesticide is called “active substance” and these active substances either consist of chemicals or micro-organisms. The aims of these active substances are to specifically take action against organisms that are harmful to plants. In other words, active substances are the active components against pests and plant diseases.