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| Proteus OX19 | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Phylum: | Pseudomonadota |
| Class: | Gammaproteobacteria |
| Order: | Enterobacterales |
| Family: | Enterobacteriaceae |
| Genus: | Proteus |
| Species: | P. vulgaris |
| Binomial name | |
| Proteus vulgaris Hauser, 1885 | |
Proteus OX19 is a strain of the Proteus vulgaris bacterium.
In 1915, Arthur Felix and Edward Weil discovered that Proteus OX19 reacted to the same human immune antibodies as typhus. Other Proteus strains were similarly used to create reagents for other rickettsiae diseases, thus resulting in the commercial Weil-Felix antibody-agglutination test.
Drs. Eugeniusz Lazowski and his medical-school friend Stanisław Matulewicz were practicing in the small town of Rozwadów in Poland during World War II. Dr. Matulewicz realized that since Proteus vulgaris strain OX19 was used to manufacture the then-common Weil-Felix antibody-agglutination test for typhus, inoculating villagers with dead Proteus would cause a false positive result without causing any disease. When the blood samples of the townspeople were sent to the German authorities for testing, authorities were convinced a typhus epidemic was raging in Rozwadów, and the area was avoided by the Germans, saving thousands of Poles. [1] [2]
The novel 1979 Night Trains, by Barbara Wood and Gareth Wootton, is a fictionalized account of the Proteus story, with details altered.[ citation needed ]
Typhoid fever, also known as typhoid, is a disease caused by Salmonella serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several days. This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting. Some people develop a skin rash with rose colored spots. In severe cases, people may experience confusion. Without treatment, symptoms may last weeks or months. Diarrhea may be severe, but is uncommon. Other people may carry it without being affected, but are still contagious. Typhoid fever is a type of enteric fever, along with paratyphoid fever. S. enterica Typhi is believed to infect and replicate only within humans.
Epidemic typhus, also known as louse-borne typhus, is a form of typhus so named because the disease often causes epidemics following wars and natural disasters where civil life is disrupted. Epidemic typhus is spread to people through contact with infected body lice, in contrast to endemic typhus which is usually transmitted by fleas.
Stalowa Wola is the largest city and capital of Stalowa Wola County with a population of 58,545 inhabitants, as at 31 December 2021. It is located in southeastern Poland in the Subcarpathian Voivodeship. The city lies in historic Lesser Poland near the confluence of the Vistula and the San rivers, and covers an area of 82.5 km2 (31.9 sq mi). Stalowa Wola is one of the youngest cities of Poland. It was built from scratch in the late 1930s in the forests surrounding village of Pławo. The city was designed to be a settlement for workers of Huta Stalowa Wola, a plant built as part of the Central Industrial Region. The name "Stalowa Wola" translates to "Steel Will" in English, reflecting its origins and purpose as a city established to support the steel industry. Stalowa Wola is home to the sports club Stal Stalowa Wola.
Boutonneuse fever is a fever as a result of a rickettsial infection caused by the bacterium Rickettsia conorii and transmitted by the dog tick Rhipicephalus sanguineus. Boutonneuse fever can be seen in many places around the world, although it is endemic in countries surrounding the Mediterranean Sea. This disease was first described in Tunisia in 1910 by Conor and Bruch and was named boutonneuse due to its papular skin-rash characteristics.
Proteus vulgaris is a rod-shaped, nitrate-reducing, indole-positive and catalase-positive, hydrogen sulfide-producing, Gram-negative bacterium that inhabits the intestinal tracts of humans and animals. It can be found in soil, water, and fecal matter. It is grouped with the Morganellaceae and is an opportunistic pathogen of humans. It is known to cause wound infections and other species of its genera are known to cause urinary tract infections.
Rudolf Stefan Jan Weigl was a Polish biologist, physician and inventor, known for creating the first effective vaccine against epidemic typhus. He was nominated for the Nobel Prize in Medicine each year between 1930 and 1934, and from 1936 to 1939.
Proteus is a genus of Gram-negative bacteria. It is a rod shaped, aerobic and motile bacteria, which is able to migrate across surfaces due its “swarming” characteristic in temperatures between 20 and 37 °C. Their size generally ranges from 0.4–0.8 μm in diameter and 1.0–3.0 μm in length. They tend to have an ammonia smell. Proteus bacilli are widely distributed in nature as saprophytes, being found in decomposing animal matter, sewage, manure soil, the mammalian intestine, and human and animal feces. They are opportunistic pathogens, commonly responsible for urinary and septic infections, often nosocomial.
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Murine typhus, also known as endemic typhus or flea-borne typhus, is a form of typhus transmitted by fleas, usually on rats, in contrast to epidemic typhus which is usually transmitted by lice. Murine typhus is an under-recognized entity, as it is often confused with viral illnesses. Most people who are infected do not realize that they have been bitten by fleas. Historically the term "hunger-typhus" was used in accounts by British POWs in Germany at the end of World War I when they described conditions in Germany.
The Weil–Felix test is an agglutination test for the diagnosis of rickettsial infections. It was first described in 1916. By virtue of its long history and of its simplicity, it has been one of the most widely employed tests for rickettsia on a global scale, despite being superseded in many settings by more sensitive and specific diagnostic tests. The Weil-Felix antibody was recently found to target rickettsia LPS O-antigen.
Beginning with the invasion of Poland during World War II, the Nazi regime set up ghettos across German-occupied Eastern Europe in order to segregate and confine Jews, and sometimes Romani people, into small sections of towns and cities furthering their exploitation. In German documents, and signage at ghetto entrances, the Nazis usually referred to them as Jüdischer Wohnbezirk or Wohngebiet der Juden, both of which translate as the Jewish Quarter. There were several distinct types including open ghettos, closed ghettos, work, transit, and destruction ghettos, as defined by the Holocaust historians. In a number of cases, they were the place of Jewish underground resistance against the German occupation, known collectively as the ghetto uprisings.
Disease surveillance is an epidemiological practice by which the spread of disease is monitored in order to establish patterns of progression. The main role of disease surveillance is to predict, observe, and minimize the harm caused by outbreak, epidemic, and pandemic situations, as well as increase knowledge about which factors contribute to such circumstances. A key part of modern disease surveillance is the practice of disease case reporting.
Rozwadów is a suburb of Stalowa Wola, Poland. Founded as a town in 1690, it was incorporated into Stalowa Wola in 1973. The Rozwadów suburb of Stalowa Wola included a thriving Jewish shtetl prior to World War II, closely associated with the Jewish communities of Tarnobrzeg and other nearby shtetls including Ulanów, Mielec, and Dzików. These communities, infused with vitality before 1939, were utterly destroyed by the Germans during the Holocaust.
Eugene Lazowski born Eugeniusz Sławomir Łazowski was a Polish medical doctor who saved thousands of people during World War II by creating a fake epidemic which played on German phobias about hygiene. He also used his position as a doctor treating people travelling through a nearby train station to conceal his supply of medicine to Jews in the local ghetto, which backed on to his home. By doing this, he risked the death penalty, which was applied to Poles who helped Jews in the Holocaust.
Orientia tsutsugamushi is a mite-borne bacterium belonging to the family Rickettsiaceae and is responsible for a disease called scrub typhus in humans. It is a natural and an obligate intracellular parasite of mites belonging to the family Trombiculidae. With a genome of only 2.0–2.7 Mb, it has the most repeated DNA sequences among bacterial genomes sequenced so far. The disease, scrub typhus, occurs when infected mite larvae accidentally bite humans. Primarily indicated by undifferentiated febrile illnesses, the infection can be complicated and often fatal.
Arthur Felix, FRS was a Polish-born microbiologist and serologist.
Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure.
Ryan Clayton Bank is an Emerging Technology Expert and Social Innovation Evangelist. Bank is the Founder of Social Intelligence Corporation, a start-up company that enables governments and corporate clients to gather Social and Open Source Intelligence. Besides advising governments and corporations on the use of Emerging Technology, Bank is also a featured speaker both nationally and internationally on the organizational value of Innovation.
Edmund Weil was a German Bohemian bacteriologist. He is best known for the Weil–Felix test used in the diagnosis of rickettsial infections. He conducted this research during World War I and died from an accidental typhus infection in his laboratory.