Puerto Rico Highway 52 (PR-52), a major toll road in Puerto Rico, is also known as Autopista Luis A. Ferré. It was formerly called Expreso Las Américas. It runs from PR-1 in southwest Río Piedras and heads south until it intersects with highway PR-2 in Ponce. At its north end, the short PR-18 continues north from PR-52 towards San Juan. This short segment is known as Expreso Las Américas, the only segment of the route still unofficially bearing this name, since PR-18 is officially named Roberto Sánchez Vilella Expressway. The combined route of PR-18 and PR-52 runs concurrent with the unsigned Interstate Highway PRI-1. Toll stations are located in San Juan, Caguas, Salinas, Juana Díaz, and Ponce.
Puerto Rico Highway 1 (PR-1) is a highway in Puerto Rico that connects the city of Ponce to San Juan. Leaving Ponce, the road heads east and follows a somewhat parallel route along the southern coast of the island heading towards Salinas. At Salinas, the road turns north to cut through the Cordillera Central in its approach to San Juan. Before reaching San Juan, it climbs to make its way to the mountain town of Cayey and then it winds down into the city of Caguas on its final approach to San Juan.
Puerto Rico Highway 111 (PR-111) is a highway connecting Aguadilla, Puerto Rico at Puerto Rico Highway 2 and Puerto Rico Highway 115 to Utuado, Puerto Rico at Puerto Rico Highway 140.
Puerto Rico Highway 15 (PR-15) is a main highway connecting Cayey and Guayama. It takes longer though, than going south to Salinas through PR-52 and taking PR-53 to Guayama, due to it being a rural road.
Puerto Rico Highway 172 (PR-172) is a secondary highway that connects Caguas, Puerto Rico at PR-1 to downtown Cidra, Puerto Rico and continues its way to its end at Puerto Rico Road 156 in Comerío, Puerto Rico. It is a two-lane per direction road from Caguas to its border point to Cidra and rural all the way to Comerío.
Puerto Rico Highway 344 (PR-344) is a rural road in Hormigueros, Puerto Rico, beginning from near the municipality's small downtown and ending at PR-348 near the border with San Germán in barrio Rosario. It has narrow lanes, and after about five kilometers becomes one of the most dangerous highways in Puerto Rico, as it goes near a precipice with little or no safety barriers. It serves as a route to Mayagüez via PR-348 which ends in Puerto Rico Alt Route 2.
Puerto Rico Highway 149 (PR-149) is a secondary highway in Puerto Rico that connects the towns of Manatí in the north coast of Puerto Rico, from PR-22 to Juana Díaz in the south coast, ending at PR-1.
Puerto Rico Highway 184 (PR-184) is a main, rural highway that connects Patillas to Cayey, Puerto Rico, with plans to be extended to Cidra. It extends from PR-3 in Cacao Bajo to PR-1 in Beatriz.
Puerto Rico Highway 165 (PR-165) is the road that goes from Naranjito to Guaynabo. The highway passes by Toa Alta, Toa Baja, Dorado, Levittown, Cataño and Guaynabo.
Puerto Rico Highway 891 (PR-891) is the road that goes to downtown Corozal, Puerto Rico. This road can be seen as the Alt 159, since this road was the PR-159 through the area from the town center.
Puerto Rico Highway 105 (PR-105) is a road that travels from Mayagüez, Puerto Rico to Maricao. It begins at its intersection with PR-239 in downtown Mayagüez and ends at its junction with PR-128 in eastern Maricao, close to Yauco municipal limit.
Puerto Rico Highway 735 (PR-735) is a rural road located between the municipalities of Cayey and Cidra, Puerto Rico, and it corresponds to an original segment of the historic Carretera Central. The Arenas and La Liendre old bridges are located on this route.
Puerto Rico Highway 722 (PR-722) is a rural road located in Aibonito, Puerto Rico. It begins at its intersection with PR-14 east of downtown Aibonito and ends at the Ruta Panorámica between Robles and Pasto barrios. The traditional Festival de las Flores is celebrated near this road.
Puerto Rico Highway 179 (PR-179) is a rural road that travels from Guayama to Cayey in Puerto Rico. It goes through Patillas but with no major junctions. This road extends from PR-15 north of downtown Guayama and ends at PR-184 in Farallón.
Puerto Rico Highway 155 (PR-155) is a rural road that goes from Coamo, Puerto Rico to Vega Baja through Orocovis and Morovis. It extends from PR-14 in downtown Coamo to PR-2 east of downtown Vega Baja.
Puerto Rico Highway 112 (PR-112) is a rural road that travels from Isabela, Puerto Rico to Moca. It begins at its intersection with PR-113 in downtown Isabela and ends at its junction with PR-125 in eastern Moca.
Puerto Rico Highway 157 (PR-157) is a rural road that travels from Ciales, Puerto Rico to Orocovis. It begins at its intersection with PR-149 in Toro Negro and ends at its junction with PR-155 near downtown Orocovis.
Puerto Rico Highway 153 (PR-153) is a rural road that goes from Santa Isabel, Puerto Rico to Coamo. This road extends from PR-1 in downtown Santa Isabel and ends at its junction with PR-14 and PR-138 near downtown Coamo.
Puerto Rico Highway 170 (PR-170) is a road located in Cayey, Puerto Rico. This highway begins at its intersection with PR-14 and PR-731 in downtown Cayey and ends at its junction with PR-1 and PR-206 in Matón Arriba.
Puerto Rico Highway 173 (PR-173) is a road that travels from Aibonito, Puerto Rico to Guaynabo, passing through Cidra and Aguas Buenas. This highway begins at PR-14 in Plata and ends at PR-1 in Río.
PR-14 in Cayey barrio-pueblo 
PR-172 / PR-734 in Cidra barrio-pueblo 
