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Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that catalyzes the breakdown of acetylcholine, a neurotransmitter. Nerve agents are irreversible acetylcholinesterase inhibitors used as poison.
Mustard gas or sulfur mustard are names commonly used for the organosulfur chemical compound bis(2-chloroethyl) sulfide, which has the chemical structure S(CH2CH2Cl)2, as well as other species. In the wider sense, compounds with the substituents −SCH2CH2X or −N(CH2CH2X)2 are known as sulfur mustards or nitrogen mustards, respectively, where X = Cl or Br. Such compounds are potent alkylating agents, which can interfere with several biological processes. Also known as mustard agents, this family of compounds comprises infamous cytotoxins and blister agents with a long history of use as chemical weapons. The name mustard gas is technically incorrect; the substances, when dispersed, are often not gases but a fine mist of liquid droplets. Sulfur mustards are viscous liquids at room temperature and have an odor resembling mustard plants, garlic, or horseradish, hence the name. When pure, they are colorless, but when used in impure forms, such as in warfare, they are usually yellow-brown. Mustard gases form blisters on exposed skin and in the lungs, often resulting in prolonged illness ending in death.
The use of toxic chemicals as weapons dates back thousands of years, but the first large-scale use of chemical weapons was during World War I. They were primarily used to demoralize, injure, and kill entrenched defenders, against whom the indiscriminate and generally very slow-moving or static nature of gas clouds would be most effective. The types of weapons employed ranged from disabling chemicals, such as tear gas, to lethal agents like phosgene, chlorine, and mustard gas. These chemical weapons caused medical problems. This chemical warfare was a major component of the first global war and first total war of the 20th century. The killing capacity of gas was profound, with about 90,000 fatalities from a total of 1.3 million casualties caused by gas attacks. Gas was unlike most other weapons of the period because it was possible to develop countermeasures, such as gas masks. In the later stages of the war, as the use of gas increased, its overall effectiveness diminished. The widespread use of these agents of chemical warfare, and wartime advances in the composition of high explosives, gave rise to an occasionally expressed view of World War I as "the chemist's war" and also the era where weapons of mass destruction were created.
Unit 731, short for Manchu Detachment 731 and also known as the Kamo Detachment and the Ishii Unit, was a covert biological and chemical warfare research and development unit of the Imperial Japanese Army that engaged in lethal human experimentation and biological weapons manufacturing during the Second Sino-Japanese War (1937–1945) and World War II. Estimates vary as to how many were killed. Between 1936 to 1945, roughly 14,000 victims were murdered in Unit 731. It is estimated that at least 300,000 individuals have died due to infectious illnesses caused by the activities of Unit 731 and its affiliated research facilities. It was based in the Pingfang district of Harbin, the largest city in the Japanese puppet state of Manchukuo and had active branch offices throughout China and Southeast Asia.
Porton Down is a science and defence technology campus in Wiltshire, England, just north-east of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory – known for over 100 years as one of the UK's most secretive and controversial military research facilities, occupying 7,000 acres (2,800 ha) – and a site of the UK Health Security Agency. Since 2018, part of the campus has housed Porton Science Park, which is owned and operated by Wiltshire Council and has private sector companies in the health, life science and defence and security sectors.
Operation Antler was a 1999 police investigation into experiments conducted on humans at the British government's Porton Down research establishment between 1939 and 1989. Several cases were sent to the Crown Prosecution Service but none proceeded to criminal prosecutions.
The United Kingdom possesses, or has possessed, a variety of weapons of mass destruction, including nuclear, biological, and chemical weapons. The United Kingdom is one of the five official nuclear weapon states under the Treaty on the Non-Proliferation of Nuclear Weapons. The UK renounced the use of chemical and biological weapons in 1956 and subsequently destroyed its general stocks.
A chemical burn occurs when living tissue is exposed to a corrosive substance or a cytotoxic agent. Chemical burns follow standard burn classification and may cause extensive tissue damage. The main types of irritant and/or corrosive products are: acids, bases, oxidizers / reducing agents, solvents, and alkylants. Additionally, chemical burns can be caused by biological toxins and by some types of cytotoxic chemical weapons, e.g., vesicants such as mustard gas and Lewisite, or urticants such as phosgene oxime.
Leading Aircraftman Ronald George Maddison was a twenty-year-old Royal Air Force mechanic who was unlawfully killed as the result of exposure to nerve agents while acting as a voluntary test subject at Porton Down, in Wiltshire, England. After substantial controversy, his death was the subject of an inquest 51 years after the event.
From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility in Maryland. The purpose was to evaluate the impact of low-dose chemical warfare agents on military personnel and to test protective clothing, pharmaceuticals, and vaccines. A small portion of these studies were directed at psychochemical warfare and grouped under the prosaic title of the "Medical Research Volunteer Program" (1956–1975). The MRVP was also driven by intelligence requirements and the need for new and more effective interrogation techniques.
Project 112 was a biological and chemical weapon experimentation project conducted by the United States Department of Defense from 1962 to 1973.
Nazi human experimentation was a series of medical experiments on prisoners by Nazi Germany in its concentration camps mainly between 1942 and 1945. There were 15,754 documented victims, of various nationalities and age groups, although the true number is believed to be more extensive. Many survived, with a quarter of documented victims being killed. Survivors generally experienced severe permanent injuries.
Operation Top Hat was a "local field exercise" conducted by the United States Army Chemical Corps in 1953. The exercise involved the use of Chemical Corps personnel to test biological and chemical warfare decontamination methods. These personnel were deliberately exposed to these contaminants, so as to test decontamination.
Numerous experiments which are performed on human test subjects in the United States are considered unethical, because they are performed without the knowledge or informed consent of the test subjects. Such tests have been performed throughout American history, but some of them are believed to be ongoing. The experiments include the exposure of humans to many chemical and biological weapons, human radiation experiments, injections of toxic and radioactive chemicals, surgical experiments, interrogation and torture experiments, tests which involve mind-altering substances, and a wide variety of other experiments. Many of these tests are performed on children, the sick, and mentally disabled individuals, often under the guise of "medical treatment". In many of the studies, a large portion of the subjects were poor, racial minorities, or prisoners.
Gassed is a very large oil painting completed in March 1919 by John Singer Sargent. It depicts the aftermath of a mustard gas attack during the First World War, with a line of wounded soldiers walking towards a dressing station. Sargent was commissioned by the British War Memorials Committee to document the war and visited the Western Front in July 1918 spending time with the Guards Division near Arras, and then with the American Expeditionary Forces near Ypres. The painting was finished in March 1919 and voted picture of the year by the Royal Academy of Arts in 1919. It is now held by the Imperial War Museum. It visited the US in 1999 for a series of retrospective exhibitions, and then from 2016 to 2018 for exhibitions commemorating the centenary of the First World War.
Chemical weapons were widely used by the United Kingdom in World War I. The use of poison gas was suggested by Winston Churchill and others in Mesopotamia during the interwar period, and also considered in World War II, although it appears that they were not actually used in these conflicts. While the UK was a signatory of the Hague Conventions of 1899 and 1907 which outlawed the use of poison gas shells, the conventions omitted mention of deployment from cylinders.
Keen as Mustard is a documentary film researched and directed by Bridget Goodwin detailing secret experiments conducted during World War II on Australian servicemen volunteers to investigate the effects of, and precautions against, mustard gas when used as a weapon in the tropics. The film, released by Film Australia in 1989, contains extensive historic documentary footage and accounts by several participants, and was made possible by the overseas acquisition of documents that remained restricted by the Australian government. A book of the same name was published in 1998, containing much additional material due to the release of some formerly restricted documents by the AWM in 1992.
Unethical human experimentation is human experimentation that violates the principles of medical ethics. Such practices have included denying patients the right to informed consent, using pseudoscientific frameworks such as race science, and torturing people under the guise of research. Around World War II, Imperial Japan and Nazi Germany carried out brutal experiments on prisoners and civilians through groups like Unit 731 or individuals like Josef Mengele; the Nuremberg Code was developed after the war in response to the Nazi experiments. Countries have carried out brutal experiments on marginalized populations. Examples include American abuses during Project MKUltra and the Tuskegee syphilis experiments, and the mistreatment of indigenous populations in Canada and Australia. The Declaration of Helsinki, developed by the World Medical Association (WMA), is widely regarded as the cornerstone document on human research ethics.
Chemical weapons have been a part of warfare in most societies for centuries. However, their usage has been extremely controversial since the 20th century.
RAF Bowes Moor was a chemical warfare agent (CWA) storage site run by the Royal Air Force during and after the Second World War. The site was to the north of the village of Bowes in what is now County Durham, England. The Bowes Moor geographical feature runs from the north to the south west of the village. The Royal Air Force used the site to stock its chemical weapon supply, most of which was disposed of in situ by burning. The site, which closed in 1947, is known for the dangerous chemicals which leached into the soil.
References
- 1 2 Evans, Rob (1 September 2007). "Military scientists tested mustard gas on Indians". The Guardian. Retrieved 28 February 2019– via www.theguardian.com.
- ↑ "UK tested poison gas on Indian soldiers - USATODAY.com". usatoday30.usatoday.com. Retrieved 28 February 2019.
- ↑ "Military scientists tested mustard gas on Indians". The Guardian. September 2007. Retrieved 13 April 2017.
- ↑ historian, Jennifer Rosenberg Jennifer Rosenberg is a; Fact-Checker, History; Topics, Freelance Writer Who Writes About 20th-Century History. "What Everyone Should Know About World War I". ThoughtCo. Retrieved 28 February 2019.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ↑ "Noticias última hora de hoy - EiTB Noticias". www.eitb.eus. Retrieved 28 February 2019.