Ray Iles

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Iles working in his laboratory Cropped Lab Ray iles.jpg
Iles working in his laboratory

Ray Kruse Iles is a biomedical scientist who was head of the Williamson Laboratory for Molecular Oncology at St Bartholomew's Hospital in London. [1]

Contents

Career

Iles has a particular interest in the interface between rational processing, emotional motivation and endocrinology. [2]

He co-founded the ELK-Health Foundation, with psychotherapist Tadhg Ó Séaghdha, in 2004. The ELK-Foundation Health (named after Iles's father, Eric Leonard Kruse) is now the National Institutes for Stress, Anxiety and Depression (NISAD), centred in Lund, Sweden. It still uses the ELK-Health name in its programmes and clinics, which support people needing to change habits that harm their physical and emotional health.

Iles's interest in women's and reproduction health led him, in 2011, to become the founding director of the biomarker diagnostic company MAPSciences. [3]

Iles is the inventor of new diagnostic technology, six clinical screening tests for pregnancy disorders and Downs Syndrome/prenatal diagnosis, [4] [5] [6] [7] [8] [9] haemoglobinopathies, thalassemia, [10] and diabetes, [11] and two cancer-related patents. [12] [13]

His academic career, after leaving St Bartholomew's, included being Professor of Biomedical Science at Middlesex University heading a Biomedical Science Research Facility, which incorporated molecular pathology, bio-modelling/bioinformatics and environmental health, [14] [15] and then Anglia Ruskin University. [16]

Formerly a regular contributor to Kumar and Clark's Clinical Medicine, [17] Iles left academia to concentrate on the two organisations that he co-founded, NISAD and MapSciences.

In 2012, with Suzanne Docherty, he published the textbook Biomedical Science: Essential Laboratory Medicine. [5]

NISAD has supported several research projects of Iles and his students in bioanalysis, [18] cancer research, [19] [20] fertility [21] and prenatal care and child development. [22] [23] [24]

In 2019 Iles became founding dean at Abu Dhabi University’s College of Health Sciences. In July 2020 he became visiting professor at the Laboratory of Viral Zoonotics, University of Cambridge. [25]

Personal life

As a boy Iles attended Mellow Lane Comprehensive School in Hayes, Middlesex. [26]

His cousin is the UK Olympic fencer Richard Kruse, which was the subject of the BBC Radio programme Tracing your Roots. [25]

Related Research Articles

<span class="mw-page-title-main">Urology</span> Medical specialty

Urology, also known as genitourinary surgery, is the branch of medicine that focuses on surgical and medical diseases of the urinary system and the reproductive organs. Organs under the domain of urology include the kidneys, adrenal glands, ureters, urinary bladder, urethra, and the male reproductive organs.

<span class="mw-page-title-main">Glioblastoma</span> Aggressive type of brain cancer

Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has a very poor prognosis for survival. Initial signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality changes, nausea, and symptoms similar to those of a stroke. Symptoms often worsen rapidly and may progress to unconsciousness.

<span class="mw-page-title-main">Metabolomics</span> Scientific study of chemical processes involving metabolites

Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles. The metabolome represents the complete set of metabolites in a biological cell, tissue, organ, or organism, which are the end products of cellular processes. Messenger RNA (mRNA), gene expression data, and proteomic analyses reveal the set of gene products being produced in the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instantaneous snapshot of the physiology of that cell, and thus, metabolomics provides a direct "functional readout of the physiological state" of an organism. There are indeed quantifiable correlations between the metabolome and the other cellular ensembles, which can be used to predict metabolite abundances in biological samples from, for example mRNA abundances. One of the ultimate challenges of systems biology is to integrate metabolomics with all other -omics information to provide a better understanding of cellular biology.

<span class="mw-page-title-main">Proton therapy</span> Medical Procedure

In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. The chief advantage of proton therapy over other types of external beam radiotherapy is that the dose of protons is deposited over a narrow range of depth; hence in minimal entry, exit, or scattered radiation dose to healthy nearby tissues.

<span class="mw-page-title-main">Hereditary nonpolyposis colorectal cancer</span> Autosomal dominant genetic condition associated with a high risk of cancer in the colon

Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.

<span class="mw-page-title-main">Neuroblastoma</span> Genetically inherited cancer of certain nerve tissues

Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the head, neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin.

<span class="mw-page-title-main">Medical research</span> Wide array of research

Medical research, also known as health research, refers to the process of using scientific methods with the aim to produce knowledge about human diseases, the prevention and treatment of illness, and the promotion of health.

The cancer Biomedical Informatics Grid (caBIG) was a US government program to develop an open-source, open access information network called caGrid for secure data exchange on cancer research. The initiative was developed by the National Cancer Institute and was maintained by the Center for Biomedical Informatics and Information Technology (CBIIT) and program managed by Booz Allen Hamilton. In 2011 a report on caBIG raised significant questions about effectiveness and oversight, and its budget and scope were significantly trimmed. In May 2012, the National Cancer Informatics Program (NCIP) was created as caBIG's successor program.

The Pennington Biomedical Research Center is a health science-focused research center in Baton Rouge, Louisiana. It is part of the Louisiana State University System and conducts clinical, basic, and population science research. It is the largest academically-based nutrition research center in the world, with the greatest number of obesity researchers on faculty. The center's over 500 employees occupy several buildings on the 222-acre (0.90 km2) campus. The center was designed by the Baton Rouge architect John Desmond.

<span class="mw-page-title-main">Society of Nuclear Medicine and Molecular Imaging</span>

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<span class="mw-page-title-main">GATA3</span> Protein-coding gene in the species Homo sapiens

GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.

The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer. Founded in 1964 by Fred Ansfield, Harry Bisel, Herman Freckman, Arnoldus Goudsmit, Robert Talley, William Wilson, and Jane C. Wright, it has nearly 45,000 members worldwide.

<span class="mw-page-title-main">Oncology</span> Branch of medicine dealing with, or specializing in, cancer

Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ὄγκος (ónkos), meaning "tumor", "volume" or "mass". Oncology is concerned with:

Alan D. D'Andrea is an American cancer researcher and the Fuller American Cancer Society Professor of Radiation Oncology at Harvard Medical School. D'Andrea's research at the Dana Farber Cancer Institute focuses on chromosome instability and cancer susceptibility. He is currently the director of the Center for DNA Damage and Repair and the director of the Susan F. Smith Center for Women's Cancer.

<span class="mw-page-title-main">Abediterol</span> Chemical compound

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<span class="mw-page-title-main">Anthony L. Komaroff</span> American physician

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<span class="mw-page-title-main">Lauren V. Wood</span> American allergist, immunologist

Lauren V. Wood is an American allergist, immunologist, and staff physician at the National Cancer Institute (NCI) at the National Institutes of Health (NIH) in Bethesda, Maryland, where she has served as a principal investigator. She is known for conducting studies of vaccines for cancer, Human papillomavirus (HPV), Hepatitis C, and HIV especially for use with children, teens and young adults. She holds the rank of captain in the U.S. Public Health Service (PHS).

Jason S. Lewis is a British radiochemist whose work relates to oncologic therapy and diagnosis. His research focus is a molecular imaging-based program focused on radiopharmaceutical development as well as the study of multimodality small- and biomolecule-based agents and their clinical translation. He has worked on the development of small molecules as well as radiolabeled peptides and antibodies probing the overexpression of receptors and antigens on tumors.

The University of Glasgow's Glasgow Precision Oncology Laboratory (GPOL) is a molecular research facility that partners with the NHS and industry to perform research into the development of novel therapeutic strategies, the creation of pan-cancer genomic assays and provide knowledge transfer for healthcare systems to enable them to develop landscapes for therapeutic testing in cancer.

<span class="mw-page-title-main">Nicholas Tatonetti</span> American bioscientist and academic

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References

  1. Cole, Laurence A.; Butler, Stephen A. (17 February 2020). 100 Years of Human Chorionic Gonadotropin: Reviews and New Perspectives. ISBN   9780128200506.
  2. "Ray Kruse Iles | BSc MSc PhD CBiol FRSB FRSC | College of Health Sciences". ResearchGate. Retrieved 2019-09-16.
  3. "MAP Sciences | Team".
  4. US 6025149,Cuckle, Howard S.; GB& GB, Raymond K.,"Urinary screening for down syndrome and other aneuploidies",issued February 15, 2000
  5. 1 2 "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  6. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  7. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  8. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  9. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  10. "United States Patent Application: 0190069352". appft.uspto.gov. Retrieved 2019-02-28.
  11. US RE47260,Zhao, Qianglin Quintin&Chen, Huaimo,"System and method for point to multipoint inter-domain MPLS traffic engineering path calculation",issued February 26, 2019
  12. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  13. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  14. "Middlesex University Centre for Investigative & Diagnostic Oncology".
  15. Brunswick, Nicola; McDougall, Sine; Davies, Paul de Mornay (10 June 2010). Reading and Dyslexia in Different Orthographies. ISBN   9781135167813.
  16. Iles, Raymond; Docherty, Suzanne (29 November 2011). Biomedical Sciences: Essential Laboratory Medicine. ISBN   9781119962410.
  17. "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  18. Trivedi, Drupad K.; Iles, Ray K. (November 2014). "Do not just do it, do it right: urinary metabolomics -establishing clinically relevant baselines: Choosing correct tools for shotgun urinary metabolomics". Biomedical Chromatography. 28 (11): 1491–1501. doi:10.1002/bmc.3219. PMID   24788800.
  19. Iles, R.K. (January 2007). "Ectopic hCGβ expression by epithelial cancer: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis". Molecular and Cellular Endocrinology. 260–262: 264–270. doi:10.1016/j.mce.2006.02.019. ISSN   0303-7207. PMID   17069968. S2CID   21216536.
  20. Butler, Stephen A.; Staite, Edyta M.; Iles, Ray K. (2003-01-01). "Reduction of Bladder Cancer Cell Growth in Response to hCGβ CTP37 Vaccinated Mouse Serum". Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 14 (2): 93–100. doi:10.3727/000000003108748649. ISSN   0965-0407. PMID   14649543.
  21. Butler, Stephen A.; Luttoo, Jameel; Freire, Maísa O. T.; Abban, Thomas K.; Borrelli, Paola T. A.; Iles, Ray K. (September 2013). "Human Chorionic Gonadotropin (hCG) in the Secretome of Cultured Embryos: Hyperglycosylated hCG and hCG-Free Beta Subunit Are Potential Markers for Infertility Management and Treatment". Reproductive Sciences. 20 (9): 1038–1045. doi:10.1177/1933719112472739. ISSN   1933-7191. PMID   23439616. S2CID   25291112.
  22. Trivedi, Drupad K.; Iles, Ray K. (August 2015). "Shotgun metabolomic profiles in maternal urine identify potential mass spectral markers of abnormal fetal biochemistry - dihydrouracil and progesterone in the metabolism of Down syndrome: Maternal urinary metabolomics markers of Down syndrome". Biomedical Chromatography. 29 (8): 1173–1183. doi:10.1002/bmc.3404. PMID   25545476.
  23. Iles, Ray; Cole, Laurence; Butler, Stephen (2014-06-05). "Direct Analysis of hCGβcf Glycosylation in Normal and Aberrant Pregnancy by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry". International Journal of Molecular Sciences. 15 (6): 10067–10082. doi: 10.3390/ijms150610067 . ISSN   1422-0067. PMC   4100140 . PMID   24905406.
  24. Butler, Stephen A.; Abban, Thomas K.A.; Borrelli, Paola T.A.; Luttoo, Jameel M.; Kemp, Bryn; Iles, Ray K. (September 2013). "Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy". Clinical Biochemistry. 46 (13–14): 1257–1263. doi:10.1016/j.clinbiochem.2013.06.019. PMID   23830901.
  25. 1 2 "Ray Iles". ResearchGate. Retrieved 13 February 2023.
  26. @Schleswigboy (5 July 2020). "Didn't realise that I was from one of the two first ever Comprehensive schools. Streamed b…" (Tweet) via Twitter.