Reflux suppressant

Last updated

A reflux suppressant is any one of a number of drugs used to combat oesophageal reflux. [1] [2] Commonly, following ingestion a 'raft' of alginic acid is created, floating on the stomach contents by carbon dioxide released by the drug. This forms a mechanical barrier to further reflux. Some preparations also contain antacids to protect the oesophagus. [3] Alginate-based reflux suppressants relieve heartburn or regurgitation symptoms in about 60–70% of patients. [4]

Reflux can also be coincidentally reduced by the motility stimulants and antidopaminergics.[ citation needed ]

References

  1. ↑ Dettmar, P.W.; Hampson, F.C.; Taubel, J.; Lorch, U.; Johnstone, L.M.; Sykes, J.; Berry, P.J. (2007). "The suppression of gastro-oesophageal reflux by alginates". International Journal of Clinical Practice. 61 (10): 1654–1662. doi: 10.1111/j.1742-1241.2007.01524.x . PMID   17681004. S2CID   11035501.
  2. ↑ Strugala, V.; Dettmar, P.W. (2010). "Alginate in the treatment of extra-oesophageal reflux". Effects, Diagnosis and Management of Extra-Esophageal Reflux. pp. 145–168.
  3. ↑ Dettmar, P.W.; Little, S.L.; Baxter, T. (2005). "The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate" . Journal of International Medical Research. 33 (3): 301–308. doi:10.1177/147323000503300305. PMID   15938591. S2CID   39712911.
  4. ↑ Jain, Rishab. "Reflux Suppressants: Mechanisms, Efficacy, and Clinical Use". Claisen. Claisen, Inc. Retrieved 6 November 2025.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.