Ribosomal protein L13 leader

Last updated
L13_leader
RF00555-rscape.svg
Consensus secondary structure and sequence conservation of Ribosomal protein L13 leader
Identifiers
SymbolL13_leader
Rfam RF00555
Other data
RNA type Cis-reg; leader
GO GO:0010468
SO SO:0000233
PDB structures PDBe
L13-Bacteroidia
RF03127.svg
Consensus secondary structure and sequence conservation of L13-Bacteroidia ribosomal protein leader
Identifiers
SymbolL13-Bacteroidia
Rfam RF03127
Other data
RNA type Cis-reg; leader
SO SO:0000837
PDB structures PDBe

L13 ribosomal protein leaders play a role in ribosome biogenesis as part of an autoregulatory mechanism to control the concentration of ribosomal proteins L13. Three structural classes of L13 ribosomal protein leaders were detected by different bioinformatics approaches: in B. subtilis and other low-GC Gram-positive bacteria., [1] in E. coli [2] [3] and in Bacteroidia. [4] Although these RNAs are expected to perform the same biological function, they do not appear to be structurally related to one another. The E. coli example has been experimentally confirmed, though the experiments are not comprehensive. [3] [2] The other two leader structures are thus far not based on experimental support.

Contents

See also

Ribosomal protein leader

References

  1. Yao Z, Barrick J, Weinberg Z, Neph S, Breaker R, Tompa M, Ruzzo WL (July 2007). "A computational pipeline for high- throughput discovery of cis-regulatory noncoding RNA in prokaryotes". PLOS Comput Biol. 3 (7): e126. Bibcode:2007PLSCB...3..126Y. doi: 10.1371/journal.pcbi.0030126 . PMC   1913097 . PMID   17616982.
  2. 1 2 Mustoe AM, Busan S, Rice GM, Hajdin CE, Peterson BK, Ruda VM, Kubica N, Nutiu R, Baryza JL, Weeks KM (March 2018). "Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing". Cell. 173 (1): 181–195.e18. doi:10.1016/j.cell.2018.02.034. PMC   5866243 . PMID   29551268.
  3. 1 2 Meyer MM (March 2018). "rRNA Mimicry in RNA Regulation of Gene Expression". Microbiol Spectr. 6 (2) 6.2.03. doi:10.1128/microbiolspec.RWR-0006-2017. PMC   11633770 . PMID   29546840.
  4. Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi: 10.1186/s12866-020-01823-6 . PMC   7247131 . PMID   32448158.