Sean Curran (scientist)

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Sean Curran is an American gerontologist who is Professor of Gerontology and Vice Dean at the USC Davis School of Gerontology with joint appointments in Molecular and Computational Biology (USC Dana and David Dornsife College of Letters, Arts and Sciences). He also serves as the Dean of Faculty and Research. His expertise is the molecular genetics of healthspan and longevity [1] with an emphasis on biology, genetics, nutrition, and diets.

Contents

Education

Curran earned his B.S. from UCLA in 1999, his Ph.D. from UCLA in 2004 and completed postdoctoral training at Harvard Medical School and Massachusetts General Hospital from 2004-2010. [2]

Research

Curran and his co-author Gary Ruvkun discovered approximately 60 highly conserved genes that are essential for development but can significantly increase lifespan when inactivated in adulthood. [3] [4]

Curran’s research group has established the existence of gene-diet pairs that predict survival and aging success. The function of these genes is essential on some diets but dispensable on others. [5] [6] [7] There are potentially hundreds, if not thousands of these gene-diet pairs, which when combined, may explain the variance in aging rates across individuals.

Awards

Selected publications

References

  1. ↑ "Sean Curran Faculty Profile". USC Davis School of Gerontology. Retrieved 6 April 2016.
  2. ↑ "CCIB: Ruvkun Lab". Archived from the original on 18 March 2012. Retrieved 20 March 2012.
  3. ↑ Wade, Nicholas (9 June 2009). "In Worms, Genetic Clues to Extending Longevity". The New York Times. Retrieved 20 March 2012.
  4. ↑ Keim, Brandon (8 June 2009). "The Secret to Roundworm Longevity: Sex Cells". Wired. Retrieved 21 March 2012.
  5. ↑ Pang, Shanshan; Curran, Sean P. (2014-02-04). "Adaptive capacity to bacterial diet modulates aging in C. elegans". Cell Metabolism. 19 (2): 221–231. doi:10.1016/j.cmet.2013.12.005. ISSN   1932-7420. PMC   3979424 . PMID   24440036.
  6. ↑ Pang, Shanshan; Lynn, Dana A.; Lo, Jacqueline Y.; Paek, Jennifer; Curran, Sean P. (2014-10-06). "SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation". Nature Communications. 5 5048. doi:10.1038/ncomms6048. ISSN   2041-1723. PMC   4205844 . PMID   25284427.
  7. ↑ Yen, Chia An; Curran, Sean P. (2016-12-15). "Gene-diet interactions and aging in C. elegans". Experimental Gerontology. 86: 106–112. doi:10.1016/j.exger.2016.02.012. ISSN   1873-6815. PMC   5001925 . PMID   26924670.
  8. ↑ "Geron > Membership > Member Center > Awards > Award Info". www.geron.org. Retrieved 2025-01-17.
  9. ↑ "Ewald W. Busse International Gerontology Research Awards | Duke Center for the Study of Aging and Human Development". agingcenter.duke.edu. Retrieved 2025-01-17.
  10. ↑ "Vincent Cristofalo Award". American Federation for Aging Research. Retrieved 2025-01-17.
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