Serial transverse enteroplasty

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Serial transverse enteroplasty
Specialty gastroenterology

Serial transverse enteroplasty (STEP) is a surgical procedure used primarily in the treatment of short bowel syndrome (SBS). In STEP, by making cuts in the intestine and creating a zigzag pattern, surgeons lengthen the amount of bowel available to absorb nutrients. The procedure was first performed in 2003 and more than 100 patients had undergone the surgery by 2013.

Contents

Background

Necrotizing enterocolitis, a potential cause of SBS Neonatal necrotizing enterocolitis, gross pathology 20G0023 lores.jpg
Necrotizing enterocolitis, a potential cause of SBS

Short bowel syndrome (SBS) is the condition in which a patient cannot absorb adequate nutrients because a portion of the small intestine is damaged or absent. SBS commonly affects pediatric patients who have undergone surgery, such as premature infants with necrotizing enterocolitis and infants with gastrointestinal defects such as gastroschisis. In adults, Crohn's disease is a possible cause of SBS. If they are unable to absorb nutrients in the gut, patients must be given parenteral nutrition (PN) intravenously, but long-term PN can be associated with liver failure. [1]

History

The procedure was studied by researchers in Boston utilizing a group of ten young pigs. Five of the pigs underwent removal of 90 percent of the bowel followed by STEP. The other pigs underwent the bowel resection without the STEP procedure, serving as control subjects. STEP was shown to lengthen the bowel from 105.2 ± 7.7 cm to 152.2 ± 8.3 cm. [2]

STEP was first performed on a human patient, a two-year-old who had been born with gastroschisis, in 2003. [3] By 2010, it had been utilized by more than 20 hospitals, mostly in the United States. [4] In addition to its use in treating SBS, STEP has been utilized to treat bacterial overgrowth in a dilated bowel loop and to prevent SBS upon the initial repair of certain types of intestinal atresia. [4]

In 2004, the International Serial Transverse Enteroplasty (STEP) Data Registry was created to serve as an online database to study outcomes following STEP. By 2013, 111 patients had been entered into the database, though 14 had been lost to follow-up. At that time, 11 patients had died and five had received intestinal transplants. 47% had attained enteral autonomy (sufficient bowel function). Pre-STEP bowel length was found to be inversely proportional to the likelihood of transplant or death. Pre-STEP direct bilirubin levels were found to be proportional to the likelihood of transplant or death. [5]

Procedure

In STEP, the bowel is dilated and then partially transected (cut) at certain points, creating a zigzag pattern to the bowel that results in lengthening of the surface area available for digestion. [3]

Longitudinal intestinal lengthening and tapering (LILT), also known as the Bianchi procedure, is a surgical alternative to STEP. LILT and STEP have similar outcomes. With each procedure, more than half of patients gain the ability to absorb sufficient nutrients in the intestine. A single-center study compared STEP and LILT, reporting fewer complications with LILT. [6]

Related Research Articles

Gastrointestinal tract Organ system within humans and other animals

The gastrointestinal tract is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. Gastrointestinal is an adjective meaning of or pertaining to the stomach and intestines.

Small intestine Organ in the gastrointestinal tract

The small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the pancreatic duct to aid in digestion. The small intestine is about 18 feet long and folds many times to fit in the abdomen. Although it is longer than the large intestine, it is called the small intestine because it is narrower in diameter.

Hirschsprungs disease Medical condition

Hirschsprung's disease is a birth defect in which nerves are missing from parts of the intestine. The most prominent symptom is constipation. Other symptoms may include vomiting, abdominal pain, diarrhea and slow growth. Symptoms usually become apparent in the first two months of life. Complications may include enterocolitis, megacolon, bowel obstruction and intestinal perforation.

In medicine, the fecal fat test is a diagnostic test for fat malabsorption conditions, which lead to excess fat in the feces (steatorrhea).

Gastric bypass surgery Type of bariatric surgery

Gastric bypass surgery refers to a technique in which the stomach is divided into a small upper pouch and a much larger lower "remnant" pouch and then the small intestine is rearranged to connect to both. Surgeons have developed several different ways to reconnect the intestine, thus leading to several different gastric bypass procedures (GBP). Any GBP leads to a marked reduction in the functional volume of the stomach, accompanied by an altered physiological and physical response to food.

Berdon syndrome Medical condition

Berdon syndrome, also called Megacystis-microcolon-intestinal hypoperistalsis syndrome, is an autosomal recessive fatal genetic disorder affecting newborns. In a 2011 study of 227 children with the syndrome, "the oldest survivor [was] 24 years old." The Ann Arbor News reported a five year old survivor at the end of 2015.

Short bowel syndrome Medical condition

Short bowel syndrome is a rare malabsorption disorder caused by a lack of functional small intestine. The primary symptom is diarrhea, which can result in dehydration, malnutrition, and weight loss. Other symptoms may include bloating, heartburn, feeling tired, lactose intolerance, and foul-smelling stool. Complications can include anemia and kidney stones.

Ileostomy

Ileostomy is a stoma constructed by bringing the end or loop of small intestine out onto the surface of the skin, or the surgical procedure which creates this opening. Intestinal waste passes out of the ileostomy and is collected in an external ostomy system which is placed next to the opening. Ileostomies are usually sited above the groin on the right hand side of the abdomen.

In medicine, the ileal pouch–anal anastomosis (IPAA), also known as an ileo-anal pouch, restorative proctocolectomy, ileal-anal pullthrough, or sometimes referred to as a j-pouch, s-pouch, w-pouch or an internal pouch, is an anastomosis of the ileum to the anus, bypassing the former site of the colon in cases where the colon has been removed. It retains or restores functionality of the anus, with stools passed under voluntary control of the patient, preventing fecal incontinence and serving as an alternative to ileostomy. The pouch component is a surgically constructed intestinal reservoir; usually situated near where the rectum would normally be. It is formed by folding loops of small intestine back on themselves and stitching or stapling them together. The internal walls are then removed thus forming a reservoir. The reservoir is then stitched or stapled into the perineum where the rectum was.

Pediatric surgery Medical subspecialty of surgery performed by pediatrics

Pediatric surgery is a subspecialty of surgery involving the surgery of fetuses, infants, children, adolescents, and young adults.

Volvulus Twisting of part of the intestine, causing a bowel obstruction

A volvulus is when a loop of intestine twists around itself and the mesentery that supports it, resulting in a bowel obstruction. Symptoms include abdominal pain, abdominal bloating, vomiting, constipation, and bloody stool. Onset of symptoms may be rapid or more gradual. The mesentery may become so tightly twisted that blood flow to part of the intestine is cut off, resulting in ischemic bowel. In this situation there may be fever or significant pain when the abdomen is touched.

The duodenal switch (DS) procedure, gastric reduction duodenal switch (GRDS), is a weight loss surgery procedure that is composed of a restrictive and a malabsorptive aspect.

Intestinal malrotation is a congenital anomaly of rotation of the midgut. It occurs during the first trimester as the fetal gut undergoes a complex series of growth and development. Malrotation can lead to a dangerous complication called volvulus. Malrotation can refer to a spectrum of abnormal intestinal positioning, often including:

Colectomy Surgical removal of any extent of the colon

Colectomy is bowel resection of the large bowel (colon). It consists of the surgical removal of any extent of the colon, usually segmental resection. In extreme cases where the entire large intestine is removed, it is called total colectomy, and proctocolectomy denotes that the rectum is included.

Duodenal cancer Medical condition

Duodenal cancer is a cancer in the first section of the small intestine known as the duodenum. Cancer of the duodenum is relatively rare compared to stomach cancer and colorectal cancer. Its histology is usually adenocarcinoma.

Intestinal atresia Medical condition

Intestinal atresia is any congenital malformation of the structure of the intestine that causes bowel obstruction. The malformation can be a narrowing (stenosis), absence or malrotation of a portion of the intestine. These defects can either occur in the small or large intestine.

Jejunoileal bypass (JIB) was a surgical weight-loss procedure performed for the relief of morbid obesity from the 1950s through the 1970s in which all but 30 cm (12 in) to 45 cm (18 in) of the small bowel were detached and set to the side.

Serum-derived bovine immunoglobulin/protein isolate (SBI) is a medical food product derived from bovine serum obtained from adult cows in the United States. It is sold under the name EnteraGam.

Intestine transplantation

Intestine transplantation is the surgical replacement of the small intestine for chronic and acute cases of intestinal failure. While intestinal failure can oftentimes be treated with alternative therapies such as parenteral nutrition (PN), complications such as PN-associated liver disease and short bowel syndrome may make transplantation the only viable option. One of the rarest type of organ transplantation performed, intestine transplantation is becoming increasingly prevalent as a therapeutic option due to improvements in immunosuppressive regimens, surgical technique, PN, and the clinical management of pre and post-transplant patients.

The longitudinal intestinal lengthening and tailoring procedure is performed by transecting the duodenum and anastomosing the duodenal stump to the pancreatic capsule or duodenal wall left in place on the pancreatic capsule. There are also another ways of performing this procedure. it is one of the surgical therapeutic options alongside with other surgical options such as small bowel segmental reversal, artificial intestinal valve construction, electrical pacing of the small bowel, serial transverse enteroplasty, or transplantation in treatment of short gut syndrome.

References

  1. "National Digestive Diseases Information Clearinghouse (NDDIC): Short Bowel Syndrome". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved March 20, 2014.
  2. Chang, Robert, Javid, Patrick, Oh, Jung-Tak, Andreoli, Steven, Kim, Heung Bae, Fauza, Dario, Jaksic, Tom (2006). "Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome". Annals of Surgery . 243 (2): 223–228. doi:10.1097/01.sla.0000197704.76166.07. PMC   1448911 . PMID   16432355.
  3. 1 2 Cameron, J. and Cameron, A. (2013). Current Surgical Therapy: Expert Consult - Online. Elsevier Health Sciences. pp. 140–142. ISBN   978-0323225113.
  4. 1 2 "Serial transverse enteroplasty (STEP) for patients with short bowel syndrome (SBS)." Horizon Scanning in Surgery: Application to Surgical Education and Practice. American College of Surgeons, December 2010.
  5. Jones, B., Hull, M., Potanos, K., Zurakowski, D., Fitzgibbons, S., Ching Y., Duggan, C., Jaksic, T., Kim H. (2013). "Report of 111 consecutive patients enrolled in the International Serial Transverse Enteroplasty (STEP) Data Registry: a retrospective observational study". Journal of the American College of Surgeons. 216 (3): 438–446. doi:10.1016/j.jamcollsurg.2012.12.018. PMC   4887155 . PMID   23357726.
  6. Mattei, Peter (2011). Fundamentals of Pediatric Surgery. Springer Publishing. pp. 387–390. ISBN   978-1441966438.