Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. It also acts as an antagonist of 5-HT2 and α-adrenergic receptors with high affinity. The compound is historically a morphine decomposition product made by boiling morphine with concentrated acid, hence the -morphine suffix. Contrary to its name, apomorphine does not actually contain morphine or its skeleton, nor does it bind to opioid receptors. The apo- prefix relates to it being a morphine derivative ("[comes] from morphine").
The Alcohol Use Disorders Identification Test (AUDIT) is a ten-item questionnaire approved by the World Health Organization to screen patients for hazardous (risky) and harmful alcohol consumption. It was developed from a WHO multi-country collaborative study, the items being selected for the AUDIT being the best performing of approximately 150 items including in the original survey. It is widely used as a summary measure of alcohol use and related problems. It has application in primary health care, medical clinics, and hospital units and performs well in these settings. Using different cut-off points, it can also screen for Alcohol Use Disorder (DSM-5) and Alcohol Dependence. Guidelines for the use of the AUDIT have been published by WHO and are available in several languages. It has become a widely used instrument and has been translated into approximately fifty languages.
Cue reactivity is a type of learned response which is observed in individuals with an addiction and involves significant physiological and psychological reactions to presentations of drug-related stimuli. The central tenet of cue reactivity is that cues previously predicting receipt of drug reward under certain conditions can evoke stimulus associated responses such as urges to use drugs. In other words, learned cues can signal drug reward, in that cues previously associated with drug use can elicit cue-reactivity such as arousal, anticipation, and changes in behavioral motivation. Responses to a drug cue can be physiological, behavioral, or symbolic expressive. The clinical utility of cue reactivity is based on the conceptualization that drug cues elicit craving which is a critical factor in the maintenance and relapse to drug use. Additionally, cue reactivity allows for the development of testable hypotheses grounded in established theories of human behavior. Therefore, researchers have leveraged the cue reactivity paradigm to study addiction, antecedents of relapse, and craving, translate pre-clinical findings to clinical samples, and contribute to the development of new treatment methods. Testing cue reactivity in human samples involves exposing individuals with a substance use disorder to drug-related cues and drug neutral cues, and then measuring their reactions by assessing changes in self-reported drug craving and physiological responses.
Anton Köllisch was a German chemist who, whilst working at Darmstadt for pharmaceutical giant Merck, first described the synthesis of the chemical MDMA.
The Collaborative Studies on the Genetics of Alcoholism (COGA) is an eleven-center research project in the United States designed to understand the genetic basis of alcoholism. Research is conducted at University of Connecticut, Indiana University, University of Iowa, SUNY Downstate Medical Center, Washington University in St. Louis, University of California at San Diego, Rutgers University, University of Texas Health Science Center at San Antonio, Virginia Commonwealth University, Icahn School of Medicine at Mount Sinai, and Howard University.
Crystal Meth Anonymous (CMA) is a California-based non-profit, public-benefit corporation founded in 1994. The members of the fellowship of Crystal Meth Anonymous work a twelve-step program of recovery with recovering crystal meth addicts. Participants in local groups meet in order to help others recover from methamphetamine addiction. CMA advocates complete abstinence from methamphetamine, alcohol, inhalants, and all other psychoactive drugs not taken as prescribed.
Leonard A. Jason is a professor of psychology at DePaul University in Chicago, Illinois, where he also directs the Center for Community Research. His chief professional interests include the study of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), violence prevention, smoking cessation, and Oxford House recovery homes for substance abuse. Jason's interest in ME/CFS began when he was diagnosed with the condition in 1990 after having mononucleosis.
The alcohol industry, also known as Big Alcohol, is the segment of the commercial drink industry that is involved in the manufacturing, distribution, and sale of alcoholic beverages. The industry has been criticised in the 1990s for deflecting attention away from the problems associated with alcohol use. The alcohol industry has also been criticised for being unhelpful in reducing the harm of alcohol.
Michael J. Kuhar, is an American neuroscientist, author, and Candler Professor of Neuropharmacology at The Emory National Primate Research Center of Emory University. He is a Georgia Research Alliance eminent scholar, and a senior fellow in the Center for Ethics at Emory. He was previously a professor at Johns Hopkins University School of Medicine and branchchief at the National Institute on Drug Abuse.
The Clinical Institute Withdrawal Assessment for Alcohol, commonly abbreviated as CIWA or CIWA-Ar, is a 10-item scale used in the assessment and management of alcohol withdrawal. Each item on the scale is scored independently, and the summation of the scores yields an aggregate value that correlates to the severity of alcohol withdrawal, with ranges of scores designed to prompt specific management decisions such as the administration of benzodiazepines. The maximum score is 67; Mild alcohol withdrawal is defined with a score less than or equal to 10, moderate with scores 11 to 15, and severe with any score equal to or greater than 16.
Brian "Nick" Heather is a clinical psychologist, alcohol researcher and Emeritus Professor of Alcohol & Other Drug Studies at Northumbria University. He was one of the pioneers of brief intervention techniques to reduce alcohol misuse, and has challenged the disease theory of alcoholism and has over five hundred research publications and books.
Shanthi Ranganathan is an Indian social worker and the founder of T. T. Ranganathan Clinical Research Foundation, a non governmental organization managing the TTK Hospital, a medical centre based in Chennai for the treatment and rehabilitation of drug and alcohol addicts. She is the first recipient of the UN Vienna Civil Society Award and a recipient of the 1992 Padma Shri, the fourth highest civilian award from the Government of India for her contributions to the society.
Norman Shanks Kerr was a Scottish physician and social reformer who is remembered for his work in the British temperance movement. He originated the Total Abstinence Society and was founder and first president of the Society for the Study and Cure of Inebriety which was founded in 1884.
Maria R. Servedio is a Canadian-American professor at the University of North Carolina at Chapel Hill. Her research spans a wide range of topics in evolutionary biology from sexual selection to evolution of behavior. She largely approaches these topics using mathematical models. Her current research interests include speciation and reinforcement, mate choice, and learning with a particular focus on evolutionary mechanisms that promote premating (prezygotic) isolation. Through integrative approaches and collaborations, she uses mathematical models along with experimental, genetic, and comparative techniques to draw conclusions on how evolution occurs. She has published extensively on these topics and has more than 50 peer-reviewed articles. She served as Vice President in 2018 of the American Society of Naturalists, and has been elected to serve as President in 2023.
Screening, Brief Intervention and Referral to Treatment (SBIRT) is a model that encourages mental health and substance use screenings as a routine preventive service in healthcare.
Scientia Professor Rebecca Q. Ivers is an Australian academic known for her work in injury prevention and trauma care research.
Shauna Michelle Cooper is an American psychologist at the University of North Carolina at Chapel Hill. Her research considers how race, culture and context influence the development of African-American young people.
Monica Malta is a Brazilian researcher who works mostly to address health inequalities faced by LGBTQ persons. She is currently a professor at the University of Toronto and a scientist at the Centre for Addiction and Mental Health. She was elected a TED fellow in 2022.
Max Meier Glatt was a German British psychiatrist and addiction expert. A survivor of the Dachau concentration camp, he went on to become a prominent expert in the treatment of addiction in the United Kingdom. He was one of the pioneers in the treatment of people with an addictive personality trait.
Brady Thomas West is an American statistician, academic and author. He is a research professor in the Survey Methodology Program (SMP) at the Survey Research Center (SRC) in the Institute for Social Research (ISR), and a research professor in the Department of Biostatistics within the School of Public Health, both at the University of Michigan, Ann Arbor. He also serves as an Adjunct Research Professor in the Joint Program in Survey Methodology (JPSM) at the University of Maryland, College Park and as an Adjunct Instructor at the Odum Institute for Research in Social Science at the University of North Carolina at Chapel Hill.
