SroB RNA

Last updated
sroB RNA
RF00368.jpg
Identifiers
SymbolsroB
Rfam RF00368
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO SO:0000655
PDB structures PDBe

The sroB RNA (also known as MicM, rybC, or ChiX) is a non-coding RNA gene of 90 nucleotides in length. sroB is found in several Enterobacterial species, but its function is unknown. [1] [2] SroB is found in the intergenic region on the opposite strand to the ybaK and ybaP genes. [1] SroB is expressed in stationary phase. [1] Experiments have shown that SroB is a Hfq binding sRNA. [2] [3]

Contents

Further evidence has shown that SroB negatively regulates the outer membrane protein YbfM by sequestering the ribosome binding site of ybfM mRNA by an antisense interaction. [4] SroB also regulates the DpiA/DpiB two-component system. [5] Furthermore, SroB itself appears to be the target of a non-coding transcript from the chbBC intergenic region. [6] [7] [8]

References

  1. 1 2 3 Vogel J, Bartels V, Tang TH, et al. (2003). "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Res. 31 (22): 6435–6443. doi:10.1093/nar/gkg867. PMC   275561 . PMID   14602901.
  2. 1 2 Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S (November 2003). "Global analysis of small RNA and mRNA targets of Hfq". Mol. Microbiol. 50 (4): 1111–1124. doi: 10.1046/j.1365-2958.2003.03734.x . PMID   14622403. S2CID   40056275.
  3. Sittka A, Lucchini S, Papenfort K, et al. (2008). Burkholder WF (ed.). "Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq". PLOS Genet. 4 (8): e1000163. doi: 10.1371/journal.pgen.1000163 . PMC   2515195 . PMID   18725932.
  4. Rasmussen AA, Johansen J, Nielsen JS, Overgaard M, Kallipolitis B, Valentin-Hansen P (April 2009). "A conserved small RNA promotes silencing of the outer membrane protein YbfM". Mol. Microbiol. 72 (3): 566–577. doi:10.1111/j.1365-2958.2009.06688.x. PMID   19400782. S2CID   24575908.
  5. Mandin, P.; Gottesman, S. (2009). "A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system". Molecular Microbiology. 72 (3): 551–565. doi:10.1111/j.1365-2958.2009.06665.x. PMC   2714224 . PMID   19426207.
  6. Overgaard M, Johansen J, Møller-Jensen J, Valentin-Hansen P (2009). "Switching off small RNA regulation with trap-mRNA". Mol Microbiol. 73 (5): 790–800. doi: 10.1111/j.1365-2958.2009.06807.x . PMID   19682266.
  7. Vogel J (July 2009). "An RNA trap helps bacteria get the most out of chitosugars". Mol. Microbiol. 73 (5): 737–741. doi:10.1111/j.1365-2958.2009.06806.x. PMID   19659640. S2CID   26358452. Archived from the original on 2013-01-05.
  8. Figueroa-Bossi N, Valentini M, Malleret L, Fiorini F, Bossi L (2009). "Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target". Genes Dev. 23 (17): 2004–2015. doi:10.1101/gad.541609. PMC   2751969 . PMID   19638370.

Further reading