Stacey Gabriel

Last updated
Stacey Gabriel
NationalityAmerican
Education Carnegie Mellon University
Case Western Reserve University
SpouseRobert Munsey
Scientific career
Fields Genomics
Institutions Broad Institute
Academic advisors Aravinda Chakravarti [1]

Stacey B. Gabriel is an American geneticist and Senior Director of the Genomics Platform at the Broad Institute. With Eric Lander, she is also the co-director of the National Human Genome Research Institute's sequencing center at the Broad Institute. [2] She was named the "hottest researcher" on Thomson Reuters' list of the World's Most Influential Scientific Minds in 2014. She was given this honor because she published twenty-three of the most cited papers of 2013, more than any other single researcher recorded by Thomson Reuters. [3] [4] She topped the same list again in 2015. [5] She is also an ISI Highly Cited Researcher. [6]

Contents

In 2020, Gabriel helped create and organize a high-throughput COVID-19 testing facility based out of the Broad Institute. [7] [8] Under her guidance, the institute has processed over 10 million tests as of April 2021. [9]

Education

Gabriel received her B.S. in molecular biology from Carnegie Mellon University in Pittsburgh, and a Ph.D. in human genetics from Case Western Reserve University in Cleveland. [2]

Life and work

Much of Gabriel’s research interests explore new uses of genomic techniques to identify the genetic basis of common diseases and gain a better understanding of them. After joining the nonprofit Whitehead Institute/MIT Center for Genome Research in 1998, her research has provided a foundation for the International HapMap Project as well as many large national projects. She has also been an active member of the steering committee for international research supporting the 1000 Genomes Project (abbreviated as 1KGP). [2]

Selected publications

Related Research Articles

<span class="mw-page-title-main">Genomics</span> Discipline in genetics

Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain.

<span class="mw-page-title-main">BGI Group</span> Chinese genome sequencing company

BGI Group, formerly Beijing Genomics Institute, is a Chinese genomics company with headquarters in Yantian, Shenzhen. The company was originally formed in 1999 as a genetics research center to participate in the Human Genome Project. It also sequences the genomes of other animals, plants and microorganisms.

<span class="mw-page-title-main">Marco Marra</span> Canadian geneticist

Marco A. Marra is a Distinguished Scientist and Director of Canada's Michael Smith Genome Sciences Centre at the BC Cancer Research Centre and Professor of Medical Genetics at the University of British Columbia (UBC). He also serves as UBC Canada Research Chair in Genome Science for the Canadian Institutes of Health Research and is an inductee in the Canadian Medical Hall of Fame. Marra has been instrumental in bringing genome science to Canada by demonstrating the pivotal role that genomics can play in human health and disease research.

<span class="mw-page-title-main">Eric Lander</span> American mathematician (born 1957)

Eric Steven Lander is an American mathematician and geneticist who is a professor of biology at the Massachusetts Institute of Technology (MIT), and a professor of systems biology at Harvard Medical School. Eric Lander is founding director emeritus of the Broad Institute of MIT and Harvard.

<span class="mw-page-title-main">Wellcome Sanger Institute</span> British genomics research institute

The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.

<span class="mw-page-title-main">Broad Institute</span> Biomedical and genomic research center

The Eli and Edythe L. Broad Institute of MIT and Harvard, often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals.

<span class="mw-page-title-main">George Church (geneticist)</span> American geneticist

George McDonald Church is an American geneticist, molecular engineer, chemist, serial entrepreneur, and pioneer in personal genomics and synthetic biology. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard University and Massachusetts Institute of Technology, and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Personal genomics or consumer genetics is the branch of genomics concerned with the sequencing, analysis and interpretation of the genome of an individual. The genotyping stage employs different techniques, including single-nucleotide polymorphism (SNP) analysis chips, or partial or full genome sequencing. Once the genotypes are known, the individual's variations can be compared with the published literature to determine likelihood of trait expression, ancestry inference and disease risk.

<span class="mw-page-title-main">Whole genome sequencing</span> Determining nearly the entirety of the DNA sequence of an organisms genome at a single time

Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.

<span class="mw-page-title-main">Institute of Genomics and Integrative Biology</span> Indian scientific research institute

CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) is a scientific research institute devoted primarily to biological research. It is a part of Council of Scientific and Industrial Research (CSIR), India.

Stephen Wayne "Steve" Scherer is a Canadian scientist who currently serves as the Chief of Research at The Hospital for Sick Children (SickKids) and distinguished University Professor at the University of Toronto. He obtained his PhD at the University of Toronto under Professor Lap-chee Tsui. Together they founded Canada's first human genome centre, the Centre for Applied Genomics (TCAG). He is a Senior Fellow of Massey College at the University of Toronto. In 2014, he was named an esteemed Clarivate Citation laureate in Physiology or Medicine for the “Discovery of large-scale gene copy number variation and its association with specific diseases.

Dr Vinod Scaria FRSB, FRSPH is an Indian biologist, medical researcher pioneering in Precision Medicine and Clinical Genomics in India. He is best known for sequencing the first Indian genome. He was also instrumental in the sequencing of The first Sri Lankan Genome, analysis of the first Malaysian Genome sequencing and analysis of the Wild-type strain of Zebrafish and the IndiGen programme on Genomics for Public Health in India.

Mark Joseph Daly is Director of the Finnish Institute for Molecular Medicine (FIMM) at the University of Helsinki, a Professor of Genetics at Harvard Medical School, Chief of the Analytic and Translational Genetic Unit at Massachusetts General Hospital, and a member of the Broad Institute of MIT and Harvard. In the early days of the Human Genome Project, Daly helped develop the genetic model by which linkage disequilibrium could be used to map the haplotype structure of the human genome. In addition, he developed statistical methods to find associations between genes and disorders such as Crohn's disease, inflammatory bowel disease, autism and schizophrenia.

Dennis T. Drayna is an American human geneticist known for his contributions to stuttering, human haemochromatosis, pitch, and taste. He is currently the Section Chief of Genetics of Communication Disorders at the U.S. National Institute for Deafness and Other Communication Disorders.

<span class="mw-page-title-main">Emmanouil Dermitzakis</span> Greek human genetics researcher

Emmanouil Theophilos Dermitzakis is a Greek human geneticist and professor in the Department of Genetic Medicine and Development at the University of Geneva, where he is also Director of the Health 2030 Genome Center. He is an ISI Highly Cited Researcher and an elected member of the European Molecular Biology Organization. He is a member of the Swiss Institute of Bioinformatics, where his research group is focused on the genetics and genomics of complex traits in humans. He has joined GlaxoSmithKline as Vice President, Computational Biology in R&D.

Medical genetic ethics is a field in which the ethics of medical genetics is evaluated. Like the other field of medicine, medical genetics also face ethical issues.

<span class="mw-page-title-main">COVID-19 Genomics UK Consortium</span> British genomics research consortium

The COVID-19 Genomics UK (COG-UK) consortium was a group of academic institutions and public health agencies in the United Kingdom created in April 2020 to collect, sequence and analyse genomes of SARS-CoV-2 at scale, as part of COVID-19 pandemic response.

<span class="mw-page-title-main">Tara Matise</span> American geneticist

Tara Matise is an American geneticist at Rutgers University. Since 2018, she has served as chair of the Department of Genetics. Her research interests span computational genetics, data science, and human genetics. She is co-director of the Rutgers University Genetics Coordinating Center.

<span class="mw-page-title-main">Deborah Nickerson</span> American human genomics researcher (1954–2021)

Deborah Ann "Debbie" Nickerson was an American human genomics researcher. She was professor of genome sciences at the University of Washington. Nickerson founded and directed of one of the five clinical sites of the Gregor Consortium and was a major contributor to many genomics projects, including the Human Genome Project and the International HapMap Project.

Jenny Carmeron Taylor is a British geneticist who is Professor of Translational Genomics at the University of Oxford. Taylor is the Director of the Oxford Biomedical Research Centre Genetics Theme. Her research considers whole genome sequencing and ways to integrate genetic research into the National Health Service.

References

  1. Evans, Catherine (29 August 2011). "Phlebotomy and the Amish Inspired this Geneticist". The Cancer Genome Atlas. Retrieved 29 January 2019.
  2. 1 2 3 "Stacey Gabriel". Broad Institute. 1 October 2013. Retrieved 29 January 2019.
  3. "HE & me - Stacey Gabriel". Times Higher Education. 25 September 2014. Retrieved 29 January 2019.
  4. Gewin, Virginia (18 February 2015). "Turning point: Stacey Gabriel". Nature. 518 (7539): 447. doi: 10.1038/nj7539-447a .
  5. Science, Thomson Reuters IP &. "Thomson Reuters Announces the World's Most Influential Scientific Minds". PR Newswire (Press release). Retrieved 29 January 2019.{{cite press release}}: |first1= has generic name (help)
  6. "Highly Cited Researchers". Clarivate Analytics. Retrieved 29 January 2019.
  7. "How A Science Giant Pivoted To Coronavirus Testing And Helped New England Colleges Salvage On-Campus Fall". www.wbur.org. Retrieved 2021-04-21.
  8. Swidney, Neil (December 10, 2020). "In just two weeks, Stacey Gabriel helped set a new COVID-19 testing standard - The Boston Globe". BostonGlobe.com. Retrieved 2021-12-25.
  9. "COVID-19 Testing". Broad Institute. 2020-07-16. Retrieved 2021-04-21.