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Leukemia, also spelled leukaemia, is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called blasts or leukemia cells. Symptoms may include bleeding and bruising, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy.
A myelodysplastic syndrome (MDS) is one of a group of cancers in which immature blood cells in the bone marrow do not mature, so do not become healthy blood cells. Early on, no symptoms typically are seen. Later, symptoms may include feeling tired, shortness of breath, bleeding disorders, anemia, or frequent infections. Some types may develop into acute myeloid leukemia.
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It may be autologous, allogeneic or syngeneic.
Edward Donnall "Don" Thomas was an American physician, professor emeritus at the University of Washington, and director emeritus of the clinical research division at the Fred Hutchinson Cancer Research Center. In 1990 he shared the Nobel Prize in Physiology or Medicine with Joseph E. Murray for the development of cell and organ transplantation. Thomas and his wife and research partner Dottie Thomas developed bone marrow transplantation as a treatment for leukemia.
Ernest Armstrong McCulloch, was a University of Toronto cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.
Shawn Christopher Burr was a professional ice hockey left winger. Burr played in the NHL for parts of 16 seasons from 1985 to 2000.
Peter Karmanos Jr. is the minority owner and alternate governor of the Carolina Hurricanes hockey franchise. He served as their principal owner from 1994 to 2018. He also owned the Plymouth Whalers junior hockey club from its establishment in 1990 until 2015, and was the majority owner of the Florida Everblades from 1998 to 2019.
Jay Feinberg is a long-term leukemia survivor, community organizer and founder and current CEO of the Gift of Life Marrow Registry.
John Edgar Dick is Canada Research Chair in Stem Cell Biology, Senior Scientist at the Princess Margaret Cancer Centre, University Health Network and Professor in the Department of Molecular Genetics at the University of Toronto in Canada. Dick is credited with first identifying cancer stem cells in certain types of human leukemia. His revolutionary findings highlighted the importance of understanding that not all cancer cells are the same and thus spawned a new direction in cancer research. Dick is also known for his demonstration of a blood stem cell's ability to replenish the blood system of a mouse, his development of a technique to enable an immune-deficient mouse to carry and produce human blood, and his creation of the world's first mouse with human leukemia.
Juvenile myelomonocytic leukemia (JMML) is a serious chronic leukemia that affects children mostly aged 4 and younger. The name JMML now encompasses all diagnoses formerly referred to as juvenile chronic myeloid leukemia (JCML), chronic myelomonocytic leukemia of infancy, and infantile monosomy 7 syndrome. The average age of patients at diagnosis is 2 years old. The World Health Organization has included JMML in the category of myelodysplastic and myeloproliferative disorders.
Thomas A. Slade was an American football quarterback who played for the University of Michigan Wolverines football team from 1971-73.
Robert Peter Gale is an American physician and medical researcher. He is known for research in leukemia and other bone marrow disorders.
The Gift of Life Marrow Registry is a public bone marrow and blood stem cell registry headquartered in Boca Raton, Florida. Gift of Life facilitates transplants for children and adults suffering from life-threatening illnesses, including leukemia, lymphoma, other cancers and genetic diseases.
The Barbara Ann Karmanos Cancer Institute, headquartered in Detroit, is the largest cancer research and provider network in Michigan and has 16 treatment locations. It is one of 51 National Cancer Institute-designated comprehensive cancer treatment and research centers in the United States. Affiliated with the Wayne State University School of Medicine, the institute has 1,000 staff members, including 300 doctors, and 100 researchers. The staff treats approximately 13,000 patients each year and operates with a budget of $260 million.
Childhood leukemia is leukemia that occurs in a child and is a type of childhood cancer. Childhood leukemia is the most common childhood cancer, accounting for 29% of cancers in children aged 0–14 in 2018. There are multiple forms of leukemia that occur in children, the most common being acute lymphoblastic leukemia (ALL) followed by acute myeloid leukemia (AML). Survival rates vary depending on the type of leukemia, but may be as high as 90% in ALL.
Allen C. Eaves was the founding Director of the Terry Fox Laboratory for Hematology/Oncology Research, which over a 25-year period (1981–2006) he grew into an internationally recognized centre for the study of leukemia and stem cell research. His own research on chronic myelogenous leukemia (CML) has led the way to a new understanding of the disease. As Head of Hematology at the British Columbia Cancer Agency and the University of British Columbia for 18 years (1985–2003) he engineered the building of one of the first and largest bone marrow transplant programs in Canada. In recognition of his research accomplishments and leadership in moving basic science discoveries in stem cell biology into the clinic, he was elected President of the International Society of Cellular Therapy (1995–1997), Treasurer of the Foundation for the Accreditation of Cellular Therapy (1995–2002) and President of the American Society of Blood and Marrow Transplantation (1999–2000). In 2003 he was awarded the prestigious R. M. Taylor Medal by the Canadian Cancer Society and the National Cancer Institute of Canada. In 2016 he was awarded the Order of British Columbia as well as named Ernst and Young's Entrepreneur Of The Year™ Pacific.
Georges Mathé was a French oncologist and immunologist. In November 1958, he performed the first successful allogeneic bone marrow transplant ever performed on unrelated human beings.
Mandi Jocelyn Schwartz was a Canadian ice hockey player with the Yale Bulldogs. She was a three time Eastern College Athletic Conference (ECAC) Hockey All-Academic, and played 73 consecutive games with the team before being diagnosed with acute myeloid leukemia in December 2008. Prior to joining Yale University, Schwartz had played minor hockey for Athol Murray College of Notre Dame in Saskatchewan. Her younger brother, Jaden currently plays for the St. Louis Blues in the National Hockey League.
Janet Liang was a prominent health advocate and activist who advocated for ethnic minorities in the United States to join the national marrow registry, the National Marrow Donor Program. In 2011, she was selected as one of Asian Pacific Americans for Progress's Unsung Heroes. In 2012, Liang won the City of Pleasanton's 2012 Juanita Haugen Community of Character Awards.
Dorothy "Dottie" Thomas was an American hematology researcher and administrator known for her work in developing bone marrow transplants. She and her husband, E. Donnall Thomas (Don), partnered to research leukemia and other blood disorders, and developed the technique for transplanting bone marrow.
References
- ↑ Handyside, Chris. "Music: In one ear". Metro Times. Retrieved 2013-11-02.
- ↑ "Stewart Francke - A Life Well Lived". Review-mag.com. 1978-09-03. Retrieved 2013-11-02.
- ↑ "Margaux Associates". Margauxpr.com. Retrieved 2013-11-02.
- ↑ "Stewart Francke To Receive Lifetime Achievement Arts Award From His Hometown Of Saginaw, MI". PRLog. Retrieved 2013-11-02.
