Sue Sisley

Last updated
Sue Sisley
Dr Sue Sisley in Lab Coat.jpg
EducationM.D. from University of Arizona College of Medicine
Occupation(s)Researcher, Doctor
Years active2009–present
Known forCannabis and Psilocybin research

Suzanne A. Sisley is an American internist and psychiatrist who is a former clinical assistant professor at the University of Arizona College of Medicine. She was terminated from her position for her advocacy around ending barriers to schedule 1 drug research.

Contents

Early life and education

Sisley was born and raised in Arizona. She earned her M.D. from the University of Arizona College of Medicine [1] and completed a dual residency in Internal Medicine and Psychiatry at Good Samaritan Regional Medical Center. [2]

Career

In 2009, Sisley founded the Scottsdale Research Institute (SRI), an LLC focused on conducting FDA-approved clinical trials on plant-based medicines such as cannabis and psilocybin mushrooms. SRI has investigated treatments for PTSD, chronic pain, opioid dependence, and end-of-life anxiety. [3] [4]

In 2021, SRI became one of the first entities in the US to receive a DEA Schedule I manufacturing license to cultivate cannabis and psilocybin mushrooms for research, [5] breaking a decades-long federal monopoly on cannabis research supply. [6]

In March 2014, Sisley's proposal to study marijuana use to treat post-traumatic stress disorder (PTSD) was approved by the National Institute on Drug Abuse. [7] After working at the University of Arizona for nearly eight years in various capacities, she was fired from the university in June 2014, ostensibly because of "funding and reorganization issues". Sisley, however, claims the firing was because of her interest in studying the potential medical uses of marijuana to treat PTSD. [8] [9] Sisley has also claimed that the university failed to provide a location for the trial to take place, and that the University of Arizona was "fearful of the word 'marijuana' and [did] not want... their brand aligned with this research." [9] After she was terminated, the university released a statement saying that they had "not received political pressure to terminate any employee as has been suggested in some media and other reports." [9]

Research

Sisley was principal investigator on the first FDA-approved randomized controlled trial assessing the safety and efficacy of smoked cannabis in military veterans with PTSD. [10] The study was conducted in partnership with the Multidisciplinary Association for Psychedelic Studies (MAPS). [11]

SRI received over $2.7 million in state funding [12] to conduct the first FDA-approved clinical trials using whole psilocybin mushrooms, [13] delivered via a standardized chocolate capsule. [14]

Advocacy and policy

Sisley has advocated for reforming federal restrictions that hinder plant-based research. She publicly challenged the DEA's cannabis monopoly, filed multiple lawsuits to expand research access, and advised state lawmakers on medical cannabis legislation. [15] She has supported bills such as Texas HB 3717, which proposes to legalize ibogaine research and treatment for PTSD and opioid dependence in Texas. [16]

Sisley also serves as a member of Colorado's Natural Medicine Advisory Board. [17]

Ethical concerns

Sisley has faced significant scrutiny and controversy regarding her research methodologies and affiliations. According to reports, veterans involved in her studies were sometimes used to promote her work and defend it against criticism, creating a façade of grassroots support while minimizing her direct involvement, a strategy that has been criticized as exploitative. [18]

Honors and recognition

Selected publications

References

  1. "Dr. Suzanne A. Sisley". US News. Retrieved 2025-09-10.
  2. "Challenging Medicine's Status Quo: Sue Sisley, MD". Arizona Physician. Retrieved 2025-09-10.
  3. Branscum, Brevan (2024-05-31). "Scottsdale Research Institute leads global 'magic mushroom' research study". ABC15 Arizona in Phoenix (KNXV). Retrieved 2025-09-10.
  4. L'Heureux, Megan (2020-02-04). "Dr. Sue Sisley: Advocating for Medical Cannabis Research, Patients, and Reform". Cannabis Science and Technology. January/February 2020. 3.
  5. Gurman, Sadie. "Marijuana Medical Research Growers Receive U.S. Approval". The Wall Street Journal. Retrieved 2025-09-10.
  6. "One doctor vs. the DEA: Inside the battle to study marijuana in America". NBC News. 2020-04-30. Retrieved 2025-09-10.
  7. Halper, Evan (1 July 2014). "Pot researcher abruptly fired by University of Arizona". Los Angeles Times. Retrieved 9 August 2014.
  8. Kovaleski, Serge F. (9 August 2014). "Medical Marijuana Research Hits Wall of U.S. Law". New York Times. Retrieved 9 August 2014.
  9. 1 2 3 Young, Saundra (14 July 2014). "Medical marijuana research stalls after Arizona professor is let go". CNN. Retrieved 9 August 2014.
  10. Bonn-Miller, Marcel O.; Sisley, Sue; Riggs, Paula; Yazar-Klosinski, Berra; Wang, Julie B.; Loflin, Mallory J. E.; Shechet, Benjamin; Hennigan, Colin; Matthews, Rebecca; Emerson, Amy; Doblin, Rick (2021). "The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial". PLOS ONE. 16 (3) e0246990. Bibcode:2021PLoSO..1646990B. doi: 10.1371/journal.pone.0246990 . ISSN   1932-6203. PMC   7968689 . PMID   33730032.
  11. Williams, Monnica T.; Reed, Sara; George, Jamilah (2021-01-15). "Culture and psychedelic psychotherapy: Ethnic and racial themes from three Black women therapists". Journal of Psychedelic Studies. 4 (3): 125–138. doi:10.1556/2054.2020.00137. ISSN   2559-9283.
  12. Branscum, Brevan (2024-05-31). "Scottsdale Research Institute leads global 'magic mushroom' research study". ABC15 Arizona in Phoenix (KNXV). Retrieved 2025-09-10.
  13. Admin, A. P. G. (2024-05-28). "Scottsdale Research Institute gears-up for 1st ever Natural Psilocybin Mushroom Human Trial Funded by State of Arizona". Arizona Progress Gazette. Retrieved 2025-09-10.
  14. Berghaus, Robin (2025-04-28). "My fight to unlock cannabis and psychedelic drugs for use in medical research" . Nature. 641 (8061): 267–269. Bibcode:2025Natur.641..267B. doi:10.1038/d41586-025-01298-3. ISSN   1476-4687.
  15. Wallace, Alicia (2019-08-27). "Bad weed is hurting cannabis research, scientists say. The DEA may finally fix that | CNN Business". CNN. Retrieved 2025-09-10.
  16. Frosch, Dan (2011-07-18). "Marijuana May Be Studied for Combat Disorder". New York Times. Retrieved 2025-09-10.
  17. Marks, Mason. "Colorado Appoints Natural Medicine Advisory Board to Shape Psychedelic Program". www.psychedelicweek.com. Retrieved 2025-09-10.
  18. Hausfeld, Russell (23 March 2023). "Who's Researching the Researchers?". Truth Dig. Retrieved 5 June 2024.
  19. "Revised Grant Application Approved; Sue Sisley to Receive Researcher of the Year Award – Multidisciplinary Association for Psychedelic Studies – MAPS". maps.org. Retrieved 2025-09-10.
  20. Brassil, Jeff Goodell,Mark Binelli,Tessa Stuart,Ben Wofford,Amanda Chicago Lewis,Zoe Carpenter,Alexander Zaitchik,Jonah Weiner,Tim Dickinson,Saul Elbein,Justin Nobel,Brian Patrick Eha,Gillian (2017-11-17). "25 People Shaping the Future". Rolling Stone. Retrieved 2025-09-10.{{cite magazine}}: CS1 maint: multiple names: authors list (link)
  21. "Challenging Medicine's Status Quo: Sue Sisley, MD". Arizona Physician. Retrieved 2025-09-10.