Medalists
| Gold | Silver | Bronze |
|---|---|---|
Crox Acuña  Venezuela | Nicolas Oliveira  Brazil | Federico Grabich  Argentina |
The Men's 50m freestyle event at the 2010 South American Games was held on March 28, with the heats at 10:00 and the Final at 18:00.
| Gold | Silver | Bronze |
|---|---|---|
| Crox Acuña Venezuela | Nicolas Oliveira Brazil | Federico Grabich Argentina |
| Standing records prior to the 2010 South American Games | ||||
|---|---|---|---|---|
| World record | César Cielo (BRA) | 20.91 | São Paulo, Brazil | 18 December 2009 |
| Competition Record | José Meolans (ARG) | 22.66 | Buenos Aires, Argentina | 17 November 2006 |
| South American record | César Cielo (BRA) | 20.91 | São Paulo, Brazil | 18 December 2009 |
| Rank | Heat | Lane | Athlete | Result | Notes |
|---|---|---|---|---|---|
| 1 | 2 | 4 | Federico Grabich (ARG) | 23.25 | Q |
| 2 | 2 | 5 | Crox Acuña (VEN) | 23.31 | Q |
| 3 | 3 | 4 | Nicolas Oliveira (BRA) | 23.34 | Q |
| 4 | 4 | 5 |  Juan Cambindo (COL) | 23.50 | Q |
| 5 | 4 | 2 | Jesus Casanova (VEN) | 23.54 | Q |
| 6 | 3 | 5 |  Oliver Elliot Banados (CHI) | 23.67 | Q |
| 7 | 4 | 4 | Guilherme Roth (BRA) | 23.69 | Q |
| 8 | 3 | 6 |  Rodrigo Caceres (URU) | 23.81 | Q |
| 9 | 4 | 6 | Martin Kutscher (URU) | 24.00 | |
| 10 | 3 | 3 | Juan Lisandro Monzon (ARG) | 24.10 | |
| 10 | 4 | 3 |  Manuel Alonso Ericsson (PER) | 24.10 | |
| 12 | 2 | 3 | Daniel Cuellar (COL) | 24.13 | |
| 13 | 2 | 1 |  Diego Zambrano Macias (ECU) | 24.16 | |
| 14 | 3 | 2 | Sebastian Arispe Silva (PER) | 24.26 | |
| 15 | 4 | 7 |  Perry Lindo (AHO) | 24.31 | |
| 16 | 2 | 6 | Hycinth Cijntje (AHO) | 24.45 | |
| 17 | 4 | 1 |  Jose Lobo Martinez (PAR) | 24.55 | |
| 18 | 3 | 1 |  Jemal le Grand (ARU) | 24.70 | |
| 19 | 2 | 2 |  Martin Tomasin Manattini (BOL) | 24.72 | |
| 20 | 1 | 4 |  Diguan Pigot (SUR) | 25.20 | |
| 21 | 3 | 8 |  Niall Roberts (GUY) | 25.38 | |
| 22 | 3 | 7 | Mario Navas Navarro (ECU) | 25.41 | |
| 23 | 1 | 3 | Fabian Binns (GUY) | 25.58 | |
| 24 | 4 | 8 | Raul Pereira de Souza (PAR) | 25.91 | |
| 25 | 2 | 8 | Armando Zayas Claure (BOL) | 27.16 | |
| 1 | 5 | Jordy Groters (ARU) | DNS | ||
| 2 | 7 | Jair Boerenveen (SUR) | DNS | ||
| Rank | Lane | Athlete | Result | Notes |
|---|---|---|---|---|
 | 5 | Crox Acuña (VEN) | 22.99 | |
 | 3 | Nicolas Oliveira (BRA) | 23.00 | |
 | 4 | Federico Grabich (ARG) | 23.10 | |
| 4 | 1 | Guilherme Roth (BRA) | 23.27 | |
| 5 | 6 | Juan Cambindo (COL) | 23.57 | |
| 6 | 2 | Jesus Casanova (VEN) | 23.61 | |
| 7 | 8 | Rodrigo Caceres (URU) | 23.76 | |
| 8 | 7 | Oliver Elliot Banados (CHI) | 23.84 | |