Medalists
| Gold | Silver | Bronze |
Andreina Pinto  Venezuela | Kristel Kobrich  Chile | Joanna Maranhão  Brazil |
The women's 800m freestyle event at the 2010 South American Games was held on March 27, with the slow heat at 10:14 and the fast heat at 18:00.
| Gold | Silver | Bronze |
| Andreina Pinto Venezuela | Kristel Kobrich Chile | Joanna Maranhão Brazil |
| Standing records prior to the 2010 South American Games | ||||
|---|---|---|---|---|
| World record |  Rebecca Adlington (GBR) | 8:14.10 | Beijing, China | 18 August 2008 |
| Competition Record | Kristel Kobrich (CHI) | 8:43.79 | Buenos Aires, Argentina | 16 November 2006 |
| South American record | Kristel Kobrich (CHI) | 8:27.90 | Rome, Italy | 31 July 2009 |
| Rank | Heat | Lane | Athlete | Result | Notes |
|---|---|---|---|---|---|
 | 2 | 3 | Andreina Pinto (VEN) | 8:40.05 | CR |
 | 2 | 4 | Kristel Kobrich (CHI) | 8:40.20 | |
 | 2 | 5 | Joanna Maranhão (BRA) | 8:42.09 | |
| 4 | 2 | 6 |  Cecilia Biagioli (ARG) | 8:56.57 | |
| 5 | 2 | 2 | Yanel Adriana Pinto (VEN) | 9:08.86 | |
| 6 | 2 | 7 | Sarah Correa (BRA) | 9:14.00 | |
| 7 | 2 | 8 |  Andrea del Rosario Rodriguez (PER) | 9:16.68 | |
| 8 | 1 | 3 |  Isabela Acuña (COL) | 9:24.86 | |
| 9 | 1 | 4 |  Katia Paola Esquivel (ECU) | 9:30.07 | |
| 10 | 1 | 5 |  Julio Laurentino (PAR) | 9:30.59 | |
| 11 | 1 | 2 | Mariana Schnettler Ramirez (CHI) | 9:35.55 | |
| 12 | 1 | 6 | Marcela Martinez (COL) | 9:43.17 | |
| 13 | 1 | 7 |  Karlene van der Jagt (SUR) | 10:22.30 | |
| 14 | 2 | 1 | Samantha Michelle Salinas (ECU) | 11:20.20 | |
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