The Men's 50m backstroke event at the 2010 South American Games was held on March 29, with the heats at 10:06 and the Final at 18:00.
| Gold | Silver | Bronze |
|---|---|---|
| Guilherme Guido | Federico Grabich | Daniel Orzechowski |
| Standing records prior to the 2010 South American Games | ||||
|---|---|---|---|---|
| World record | 24.04 | Rome, Italy | 2 August 2009 | |
| Competition Record | 26.25 | Buenos Aires, Argentina | 18 November 2006 | |
| South American record | 24.49 | Rome, Italy | 1 August 2009 | |
| Rank | Heat | Lane | Athlete | Result | Notes |
|---|---|---|---|---|---|
| 1 | 3 | 4 | 25.47 | Q CR | |
| 2 | 2 | 4 | 26.05 | Q | |
| 3 | 1 | 4 | 26.37 | Q | |
| 4 | 3 | 5 | 26.71 | Q | |
| 5 | 2 | 5 | 26.77 | Q | |
| 6 | 3 | 3 | 27.20 | Q | |
| 7 | 2 | 6 | 27.19 | Q | |
| 8 | 2 | 3 | 27.48 | Q | |
| 9 | 1 | 5 | 27.69 | ||
| 10 | 1 | 6 | 27.74 | ||
| 11 | 1 | 3 | 27.94 | ||
| 12 | 3 | 2 | 27.99 | ||
| 13 | 3 | 6 | 28.41 | ||
| 14 | 1 | 2 | 28.65 | ||
| 15 | 2 | 7 | 29.04 | ||
| 16 | 2 | 2 | 29.09 | ||
| 17 | 3 | 7 | 30.03 | ||
| 18 | 1 | 7 | 30.88 | ||
| Rank | Lane | Athlete | Result | Notes |
|---|---|---|---|---|
| 4 | 25.09 | CR | ||
| 3 | 25.69 | |||
| 5 | 26.05 | |||
| 4 | 2 | 26.35 | ||
| 4 | 6 | 26.35 | ||
| 6 | 1 | 26.97 | ||
| 7 | 7 | 27.62 | ||
| 8 | 8 | 28.07 | ||