The Presbyterian Church (USA), abbreviated PC(USA), is a mainline Protestant denomination in the United States. It is the largest Presbyterian denomination in the US, and known for its liberal stance on doctrine and its ordaining of women and members of the LGBT community as elders and ministers. The PC(USA) was established by the 1983 merger of the Presbyterian Church in the United States, whose churches were located in the Southern and border states, with the United Presbyterian Church in the United States of America, whose congregations could be found in every state. The similarly named Presbyterian Church in America is a separate denomination whose congregations can also trace their history to the various schisms and mergers of Presbyterian churches in the United States. Unlike the PCA, the PC(USA) supports the ordination of women and affirms same-sex marriage. It also welcomes practicing gay and lesbian persons to serve in leadership positions as ministers, deacons, elders, and trustees.

The Presbyterian Church in America (PCA) is the second-largest Presbyterian church body, behind the Presbyterian Church (USA), and the largest conservative Calvinist denomination in the United States. The PCA is Reformed in theology and presbyterian in government.

The Presbyterian Church in the United States was a Protestant denomination in the Southern and border states of the United States that existed from 1861 to 1983. That year, it merged with the United Presbyterian Church in the United States of America (UPCUSA) to form the Presbyterian Church (USA).

The United Presbyterian Church in the United States of America (UPCUSA) was the largest branch of Presbyterianism in the United States from May 28, 1958, to 1983. It was formed by the union of the Presbyterian Church in the United States of America (PCUSA), often referred to as the "Northern" Presbyterian Church, with the United Presbyterian Church of North America (UPCNA), a smaller church of Covenanter-Seceder tradition at a conference in downtown Pittsburgh, Pennsylvania, in May 1958. Vigorous ecumenical activity on the part of PCUSA leaders led to this merger, something of a reunion of two long-separated branches of the larger Presbyterian family deriving from the British Isles.

The Associate Reformed Presbyterian Church (ARPC), as it exists today, is the historical descendant of the Synod of the South, a Synod of the Associate Reformed Church. The original Associate Reformed Church resulted from a merger of the Associate Presbytery and most of the Reformed Presbytery in Philadelphia in 1782. The northern Synods eventually merged with the forebearers of the Presbyterian Church (USA). Because of its 1782 date of origin, it is one of the oldest of the United States' theologically and socially conservative denominations.

The Presbyterian Church in the United States of America (PCUSA) was the first national Presbyterian denomination in the United States, existing from 1789 to 1958. In that year, the PCUSA merged with the United Presbyterian Church of North America, a denomination with roots in the Seceder and Covenanter traditions of Presbyterianism. The new church was named the United Presbyterian Church in the United States of America. It was a predecessor to the contemporary Presbyterian Church (USA).

The Bible Presbyterian Church is an American Protestant denomination in the Calvinist tradition.

Synod of the Trinity is an upper judicatory of the Presbyterian Church headquartered in Camp Hill, Pennsylvania. The synod oversees sixteen presbyteries covering all of Pennsylvania, most of West Virginia, and a portion of eastern Ohio.

The Old School–New School controversy was a schism of the Presbyterian Church in the United States of America which took place in 1837 and lasted for over 20 years. The Old School, led by Charles Hodge of Princeton Theological Seminary, was much more conservative theologically and did not support the revival movement. It called for traditional Calvinist orthodoxy as outlined in the Westminster standards.

The Reformed Presbyterian Church of North America (RPCNA) is a Presbyterian church with congregations and missions throughout the United States, Canada, Japan, and Chile. Its beliefs—held in common with other members of the Reformed Presbyterian Global Alliance—place it in the conservative wing of the Reformed family of Protestant churches. Below the Bible—which is held as divinely inspired and without error—the church is committed to several "subordinate standards," together considered with its constitution: the Westminster Confession of Faith and Larger and Shorter Catechisms, along with its Testimony, Directory for Church Government, the Book of Discipline, and Directory for Worship.

The National Capital Presbytery is a judicatory of the Presbyterian Church (USA) based in Rockville, Maryland. The presbytery oversees 108 churches in two Mid-Atlantic states and the District of Columbia. NCP is a presbytery of the Synod of the Mid-Atlantic.

ECO: A Covenant Order of Evangelical Presbyterians is an evangelical Presbyterian denomination in the United States. As a Presbyterian church, ECO adheres to Reformed theology and Presbyterian polity. It was established in 2012 by former congregations and members of the Presbyterian Church (USA), abbreviated PC(USA). Denominational disputes over theology—particularly ordination of practicing homosexuals as pastors and gay marriage—and bureaucracy led to the founding of ECO. In 2018, ECO has over 383 congregations, 103,425 covenant partners and over 500 pastors. ECO churches are egalitarian in beliefs and ordain women as pastors and elders.

Presbyterianism has had a presence in the United States since colonial times and has exerted an important influence over broader American religion and culture.

First Presbyterian Church of Arlington, Virginia is a congregation in the National Capital Presbytery, the Synod of Mid-Atlantic and the Presbyterian Church (USA).