In neurobiology, a tetanic stimulation consists of a high-frequency sequence of individual stimulations of a neuron.[1] It is associated with potentiation.
High-frequency stimulation causes an increase in release called post-tetanic potentiation (Kandel 2003).[citation needed] This presynaptic event is caused by calcium influx. Calcium-protein interactions then produce a change in vesicleexocytosis. The result of these changes is to make the postsynaptic cell more likely to fire an action potential.
Tetanic stimulation is used in medicine to detect a non-depolarizing block or a depolarizing block on the neuromuscular junction.[2] Lower elicitations of tetanic stimulation in aged muscles were shown to be caused by lower levels of anaerobic energy provision in skeletal muscles.
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