Tuolumne may refer to:
- Tuolumne River, one of the major rivers draining the western slope of the Sierra Nevada mountains
- Tuolumne Grove, of giant sequoia trees, in Yosemite National Park
- Tuolumne Meadows, in the eastern section of Yosemite National Park
- Grand Canyon of the Tuolumne, also in Yosemite National Park
- Tuolumne County, California, located in the Sierra Nevada
- Tuolumne City, California, an unincorporated community in Tuolumne County
- Tuolumne Peak
- "Tuolumne", a song by Eddie Vedder from the soundtrack for Into the Wild
- Toulumne, Dan Cody's yacht in The Great Gatsby by F. Scott Fitzgerald
This disambiguation page lists articles associated with the title Tuolumne.
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