UGT1A

UGT1A
Identifiers
Aliases	UGT1A , GNT1, UGT, UGT1, UGT1A@, UDP glucuronosyltransferase family 1 member A complex locus
External IDs	GeneCards: UGT1A
Orthologs
	7361
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	n ; a
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	Wikidata
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Last updated February 02, 2024

UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus which includes several UDP glucuronosyltransferases.^[2]

The UGT1A locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.^[2]

Related Research Articles

<span class="mw-page-title-main">Gilbert's syndrome</span> Medical condition

Gilbert syndrome (GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority. Many people never have symptoms. Occasionally jaundice may occur.

<span class="mw-page-title-main">Glucuronosyltransferase</span> Class of enzymes

Uridine 5'-diphospho-glucuronosyltransferase is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction.

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.

UDP-glucuronosyltransferase 1-3 is an enzyme that in humans is encoded by the UGT1A3 gene.

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.

Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene.

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine.

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.

References

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: UGT1A@ UDP glucuronosyltransferase 1 family, polypeptide A cluster".

Mackenzie PI, Owens IS, Burchell B, et al. (1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. doi:10.2174/1389200003339171. PMID 11465080.
Ritter JK, Chen F, Sheen YY, et al. (1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J. Biol. Chem. 267 (5): 3257–61. doi: 10.1016/S0021-9258(19)50724-4 . PMID 1339448.
Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
Kaplan M, Hammerman C, Rubaltelli FF, et al. (2002). "Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism". Hepatology. 35 (4): 905–11. doi: 10.1053/jhep.2002.32526 . hdl:11577/2431311. PMID 11915038. S2CID 10749512.
Peters WH, te Morsche RH, Roelofs HM (2003). "Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome". J. Hepatol. 38 (1): 3–8. doi:10.1016/S0168-8278(02)00306-9. PMID 12480553.
Zhang T, Haws P, Wu Q (2004). "Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation". Genome Res. 14 (1): 79–89. doi:10.1101/gr.1225204. PMC 314283 . PMID 14672974.
Giuliani L, Ciotti M, Stoppacciaro A, et al. (2005). "UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry". Oncol. Rep. 13 (2): 185–91. doi:10.3892/or.13.2.185 (inactive 31 January 2024). PMID 15643497.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
Mercke Odeberg J, Andrade J, Holmberg K, et al. (2007). "UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females". Eur. J. Clin. Pharmacol. 62 (10): 829–37. doi:10.1007/s00228-006-0166-3. PMID 16909274. S2CID 30425233.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] 1 2 "Entrez Gene: UGT1A@ UDP glucuronosyltransferase 1 family, polypeptide A cluster".

[1]

[2]

UGT1A

Related Research Articles

References

Further reading