Related Research Articles
Biological warfare, also known as germ warfare, is the use of biological toxins or infectious agents such as bacteria, viruses, insects, and fungi with the intent to kill, harm or incapacitate humans, animals or plants as an act of war. Biological weapons are living organisms or replicating entities. Entomological (insect) warfare is a subtype of biological warfare.
The Black Death was a bubonic plague pandemic occurring in Western Eurasia and North Africa from 1346 to 1353. It is the most fatal pandemic recorded in human history, causing the deaths of approximately 40% to 60% of Europe's population peaking in Europe from 1347 to 1351. Bubonic plague is caused by the bacterium Yersinia pestis spread by fleas, but during the Black Death it probably also took a secondary form, spread by person-to-person contact via aerosols, causing pneumonic plague.
Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms. Pneumonic plague infects the lungs, causing shortness of breath, coughing and chest pain; bubonic plague affects the lymph nodes, making them swell; and septicemic plague infects the blood and can cause tissues to turn black and die.
Yersinia pestis is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both Yersinia enterocolitica and Yersinia pseudotuberculosis, the pathogen from which Y. pestis evolved and responsible for the Far East scarlet-like fever. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea. It causes the disease plague, which caused the Plague of Justinian and the Black Death, the deadliest pandemic in recorded history. Plague takes three main forms: pneumonic, septicemic, and bubonic. Yersinia pestis is a parasite of its host, the rat flea, which is also a parasite of rats, hence Y. pestis is a hyperparasite.
The All-Union Science Production Association Biopreparat was a Soviet agency created in April 1974, which spearheaded the largest and most sophisticated offensive biological warfare program the world has ever seen. It was a vast, ostensibly civilian, network employing 30–40,000 personnel and incorporating five major military-focused research institutes, numerous design and instrument-making facilities, three pilot plants and five dual-use production plants. The network pursued major offensive research and development programs which genetically engineered microbial strains to be resistant to an array of antibiotics. In addition, bacterial agents were created with the ability to produce various peptides, yielding strains with wholly new and unexpected pathogenic properties.
The plague of Justinian or Justinianic plague was an epidemic that afflicted the entire Mediterranean Basin, Europe, and the Near East, severely affecting the Sasanian Empire and the Byzantine Empire, especially Constantinople. The plague is named for the Byzantine Emperor Justinian I, who according to his court historian Procopius contracted the disease and recovered in 542, at the height of the epidemic which killed about a fifth of the population in the imperial capital. The contagion arrived in Roman Egypt in 541, spread around the Mediterranean Sea until 544, and persisted in Northern Europe and the Arabian Peninsula until 549. By 543, the plague had spread in every corner of the empire. As the first episode of the first plague pandemic, it had profound economic, social, and political effects across Europe and the Near East and cultural and religious impact on Eastern Roman society.
Unit 100 was an Imperial Japanese Army facility called the Kwantung Army Warhorse Disease Prevention Shop that focused on the development of biological weapons during World War II. It was operated by the Kempeitai, the Japanese military police. Its headquarters was located in Mokotan, Manchukuo, a village just south of the city of Changchun. It had branches in Dairen and Hailar. The Hailar branch was later transferred to Foshan. Between 600 and 800 people worked at Unit 100.
Yersinia enterocolitica is a Gram-negative, rod-shaped bacterium, belonging to the family Yersiniaceae. It is motile at temperatures of 22–29°C (72–84°F), but becomes nonmotile at normal human body temperature. Y. enterocolitica infection causes the disease yersiniosis, which is an animal-borne disease occurring in humans, as well as in a wide array of animals such as cattle, deer, pigs, and birds. Many of these animals recover from the disease and become carriers; these are potential sources of contagion despite showing no signs of disease. The bacterium infects the host by sticking to its cells using trimeric autotransporter adhesins.
A bubo is adenitis or inflammation of the lymph nodes and is an example of reactive lymphadenopathy.
Erich Traub was a German veterinarian, scientist and virologist who specialized in foot-and-mouth disease, Rinderpest and Newcastle disease. Traub was a member of the National Socialist Motor Corps (NSKK), a Nazi motorist corps, from 1938 to 1942. He worked directly for Heinrich Himmler, head of the Schutzstaffel (SS), as the lab chief of the Nazis' leading bio-weapons facility on Riems Island.
The Soviet Union covertly operated the world's largest, longest, and most sophisticated biological weapons program, thereby violating its obligations as a party to the 1972 Biological Weapons Convention. The program began in the 1920s and lasted until at least September 1992 but has possibly been continued by Russia after that.
Bubonic plague is one of three types of plague caused by the bacterium Yersinia pestis. One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. Acral necrosis, the dark discoloration of skin, is another symptom. Occasionally, swollen lymph nodes, known as "buboes", may break open.
Vladimir Artemovich Pasechnik was a senior Soviet biologist and bioweaponeer who defected to the United Kingdom in 1989, alerting Western intelligence to the vast scope of Moscow's clandestine biological warfare (BW) programme, known as Biopreparat. His revelations that the program was ten times larger than previously suspected were confirmed in 1992 with the defection to the United States of Colonel Kanatjan Alibekov, the No. 2 scientist for the program.
Theories of the Black Death are a variety of explanations that have been advanced to explain the nature and transmission of the Black Death (1347–51). A number of epidemiologists from the 1980s to the 2000s challenged the traditional view that the Black Death was caused by plague based on the type and spread of the disease. The confirmation in 2010 and 2011 that Yersinia pestis DNA was associated with a large number of plague sites has led researchers to conclude that "Finally, plague is plague."
Project Jefferson was a covert U.S. Defense Intelligence Agency program designed to determine if the current anthrax vaccine was effective against genetically modified bacteria. The program's legal status under the 1972 Biological Weapons Convention (BWC) is disputed.
Sergei Popov is a Russian biologist and bioweaponeer formerly in the Soviet biological weapons program. He defected to the West in 1992 and now lives and works in the United States.
The Aral smallpox incident was a 30 July 1971 outbreak of the viral disease which occurred as a result of a field test at a Soviet biological weapons (BW) facility on an island in the Aral Sea. The incident sickened ten people, of whom three died, and came to widespread public notice only in 2002.
Biological warfare (BW)—also known as bacteriological warfare, or germ warfare—has had a presence in popular culture for over 100 years. Public interest in it became intense during the Cold War, especially the 1960s and '70s, and continues unabated. This article comprises a list of popular culture works referencing BW or bioterrorism, but not those pertaining to natural, or unintentional, epidemics.
Mark L. Nelson (1960-) is an American chemist specializing in the field of antibiotics and tetracyclines. His synthesis techniques have resulted in over 40 patents and he conceived and synthesized with Mohamed Ismail along with Laura Honeyman, the tetracycline antibiotic Omadacycline (Nuzyra), the first of the Aminomethylcycline subclass of tetracyclines to reach medical use. Nuzyra is useful against resistant bacteria and used for severe cases of skin infections, ABSSSIs, Community Acquired Pneumonia (CABP) and nontuberculosis mycobacteria. Nuzyra also has demonstrated activity against Anthrax, and was purchased by the US government under a BARDA contract for Project Bio-shield to treat anthrax exposure, and is now in the Strategic National Stockpile in the US in case of a bioterrorism attack. Nuzyra was also approved for use against the Plague, caused by Yersinia pestis infections.
The Neolithic decline was a rapid collapse in populations between 5000 and 6000 years ago during the Neolithic period in western Eurasia. The specific causes of that broad population decline are still debated. While heavily populated settlements were regularly created, abandoned, and resettled during the Neolithic, after around 5400 years ago, a great number of those settlements were permanently abandoned. The population decline is associated with worsening agricultural conditions and a decrease in cereal production. Other suggested causes include the emergence of communicable diseases spread from animals living in close quarters with humans.
References
- ↑ Armstrong, Robert E. (2005). "Review of Biowarrior—Inside the Soviet/Russian Biological War Machine". Armed Forces & Society. 32 (1): 146–149. doi:10.1177/0095327X05278899. ISSN 0095-327X. JSTOR 48608677. S2CID 144162845.
- ↑ Amazon.com: Biowarrior
- ↑ Amazon.com: Plague
| International | |
|---|---|
| National | |
| Other | |
