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The citric acid cycle —also known as the Krebs cycle, Szent-Györgyi-Krebs cycle or the TCA cycle (tricarboxylic acid cycle)—is a series of chemical reactions to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The Krebs cycle is used by organisms that respire (as opposed to organisms that ferment) to generate energy, either by anaerobic respiration or aerobic respiration. In addition, the cycle provides precursors of certain amino acids, as well as the reducing agent NADH, that are used in numerous other reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest components of metabolism. Even though it is branded as a 'cycle', it is not necessary for metabolites to follow only one specific route; at least three alternative segments of the citric acid cycle have been recognized.
Metabolism is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary metabolism.
Carl Peter Henrik Dam was a Danish biochemist and physiologist.
Pyruvic acid (IUPAC name: 2-oxopropanoic acid, also called acetoic acid) (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH3COCOO−, is an intermediate in several metabolic pathways throughout the cell.
Sir Hans Adolf Krebs, FRS was a German-British biologist, physician and biochemist. He was a pioneer scientist in the study of cellular respiration, a biochemical process in living cells that extracts energy from food and oxygen and makes it available to drive the processes of life. He is best known for his discoveries of two important sequences of chemical reactions that take place in the cells of nearly all organisms, including humans, other than anaerobic microorganisms, namely the citric acid cycle and the urea cycle. The former, often eponymously known as the "Krebs cycle", is the sequence of metabolic reactions that allows cells of oxygen-respiring organisms to obtain far more ATP from the food they consume than anaerobic processes such as glycolysis can supply; and its discovery earned Krebs a Nobel Prize in Physiology or Medicine in 1953. With Hans Kornberg, he also discovered the glyoxylate cycle, a slight variation of the citric acid cycle found in plants, bacteria, protists, and fungi.
Otto Heinrich Warburg, son of physicist Emil Warburg, was a German physiologist, medical doctor, and Nobel laureate. He served as an officer in the elite Uhlan during the First World War, and was awarded the Iron Cross for bravery. He was the sole recipient of the Nobel Prize in Physiology or Medicine in 1931. In total, he was nominated for the award 47 times over the course of his career.
Fritz Albert Lipmann was a German-American biochemist and a co-discoverer in 1945 of coenzyme A. For this, together with other research on coenzyme A, he was awarded the Nobel Prize in Physiology or Medicine in 1953.
Werner Arber is a Swiss microbiologist and geneticist. Along with American researchers Hamilton Smith and Daniel Nathans, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonucleases. Their work would lead to the development of recombinant DNA technology.
Edmond Henri Fischer was a Swiss-American biochemist. He and his collaborator Edwin G. Krebs were awarded the Nobel Prize in Physiology or Medicine in 1992 for describing how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes. From 2007 until 2014, he was the Honorary President of the World Cultural Council. At the time of his death at age 101 in 2021, he was the oldest living Nobel Prize laureate.
Sir Hans Leo Kornberg, FRS was a British-American biochemist. He was Sir William Dunn Professor of Biochemistry in the University of Cambridge from 1975 to 1995, and Master of Christ's College, Cambridge from 1982 to 1995.
Norman Lowther Edson, FRSNZ, FNZIC, was the first Professor of Biochemistry (1949–1967) in the University of New Zealand based at the University of Otago, Dunedin, New Zealand where he founded a department of biochemistry. Edson made contributions to the understanding of, ketone body metabolism in mammals and birds, metabolic pathways of Mycobacteria and specificity rules for polyol dehydrogenases.
The Department of Biochemistry of Oxford University is located in the Science Area in Oxford, England. It is one of the largest biochemistry departments in Europe. The Biochemistry Department is part of the University of Oxford's Medical Sciences Division, the largest of the university's four academic divisions, which has been ranked first in the world for biomedicine.
The history of biochemistry can be said to have started with the ancient Greeks who were interested in the composition and processes of life, although biochemistry as a specific scientific discipline has its beginning around the early 19th century. Some argued that the beginning of biochemistry may have been the discovery of the first enzyme, diastase, in 1833 by Anselme Payen, while others considered Eduard Buchner's first demonstration of a complex biochemical process alcoholic fermentation in cell-free extracts to be the birth of biochemistry. Some might also point to the influential work of Justus von Liebig from 1842, Animal chemistry, or, Organic chemistry in its applications to physiology and pathology, which presented a chemical theory of metabolism, or even earlier to the 18th century studies on fermentation and respiration by Antoine Lavoisier.
The Sir Hans Krebs Lecture and Medal is awarded annually by the Federation of European Biochemical Societies (FEBS) for outstanding achievements in Biochemistry and Molecular Biology or related sciences.
Jacques Dubochet is a retired Swiss biophysicist. He is a former researcher at the European Molecular Biology Laboratory in Heidelberg, Germany, and an honorary professor of biophysics at the University of Lausanne in Switzerland.
Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction, is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex.
Iain Macintyre FRS was a British endocrinologist who made important contributions to the understanding of calcium regulation and bone metabolism. Shortly after the hormone calcitonin had been described by Harold Copp, Macintyre's team was the first to isolate and sequence the hormone and to demonstrate its origin in the parafollicular cells of the thyroid gland. He subsequently analysed its physiological actions. Along with H. R. Morris he isolated and sequenced calcitonin gene-related peptide. Later research centred on the role played by nitric oxide on bone metabolism.
Ronald Whittam was an English research scientist in the field of cell physiology. He conducted important studies on the mechanism of active transport of ions across animal membranes and its relation to cellular metabolism. Whittam was the inaugural Chair in Physiology at the University of Leicester, where he was subsequently an Emeritus Professor.
John Rodney (Rod) Quayle FRS (1926–2006) was a microbial biochemist, West Riding Professor of Microbiology and Head of Department at University of Sheffield (1965–1983) and then Vice-Chancellor of Bath University (1983–1992). He adopted techniques for dissecting enzymic reactions using radioactive carbon-14. He focused on microbes that used compounds containing one atom of carbon as their sources of energy and biomass.
Lester Orville Krampitz was an American microbiologist.
References
- 1 2 3 Wilson, Bryan A.; Schisler, Jonathan C.; Willis, Monte S. (2010-06-01). "Sir Hans Adolf Krebs: Architect of Metabolic Cycles". Laboratory Medicine. 41 (6): 377–380. doi: 10.1309/LMZ5ZLAC85GFMGHU . S2CID 56651764 . Retrieved 2023-10-01.
- 1 2 3 4 5 6 7 8 Wainwright, Milton (February 1993). "William Arthur Johnson – a postraduate's contribution to the Krebs cycle". Trends in Biochemical Sciences. 18 (2): 61–62. doi:10.1016/0968-0004(93)90057-T. PMID 8488561 . Retrieved 2023-10-01.
- ↑ "Sir Hans Krebs – Lectures | Lindau Mediatheque". Lindau Nobel Mediatheque. 2023-02-24. Retrieved 2023-10-01.
- ↑ "Coping with peer rejection". Nature. 425 (6959): 645. 2003-10-16. Bibcode:2003Natur.425..645.. doi: 10.1038/425645a . ISSN 1476-4687. PMID 14562060. S2CID 4380827 . Retrieved 2023-10-01.
- ↑ Abbott, Alison (2006), Wormer, Holger (ed.), "Wissenschaft bei einer internationalen Fachzeitschrift I: Between Peer Review and a Science Journalism Generator", Die Wissensmacher: Profile und Arbeitsfelder von Wissenschaftsredaktionen in Deutschland (in German), Wiesbaden: VS Verlag für Sozialwissenschaften, pp. 298–313, doi:10.1007/978-3-531-90310-1_19, ISBN 978-3-531-90310-1 , retrieved 2023-10-01