Related Research Articles
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary. The primary stage classically presents with a single chancre though there may be multiple sores. In secondary syphilis, a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. There may also be sores in the mouth or vagina. Latent syphilis has no symptoms and can last years. In tertiary syphilis, there are gummas, neurological problems, or heart symptoms. Syphilis has been known as "the great imitator" because it may cause symptoms similar to many other diseases.
Warts are non-cancerous viral growths usually occurring on the hands and feet but which can also affect other locations, such as the genitals or face. One or many warts may appear. They are distinguished from cancerous tumors as they are caused by a viral infection, such as a human papillomavirus, rather than a cancer growth.
Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel, and yaws. It is known to be transmitted only among humans and baboons. T. pallidum can enter the host through mucosal membranes or open lesions in the skin and is primarily spread through sexual contact. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. T. pallidum's lack of both a tricarboxylic acid cycle and processes for oxidative phosphorylation results in minimal metabolic activity. As a chemoorganoheterotroph, Treponema pallidum is an obligate parasite that acquires its glucose carbon source from its host. Glucose can be used not only as a primary carbon source but also in glycolytic mechanisms to generate ATP needed to power the bacterium given its minimal genome. The treponemes have cytoplasmic and outer membranes. Using light microscopy, treponemes are visible only by using dark-field illumination. T. pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct related disorder. The ability of T. pallidum to avoid host immune defenses has allowed for stealth pathogenicity. The unique outer membrane structure and minimal expression of surface proteins of T. pallidum has made vaccine development difficult. Treponema pallidum can be treated with high efficacy by antibiotics that inhibit bacterial cell wall synthesis such as the beta-lactam antimicrobial penicillin-G.
The Tuskegee Study of Untreated Syphilis in the Negro Male was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with syphilis. The purpose of the study was to observe the effects of the disease when untreated, though by the end of the study medical advancements meant it was entirely treatable. The men were not informed of the nature of the experiment, and more than 100 died as a result.
Yaws is a tropical infection of the skin, bones, and joints caused by the spirochete bacterium Treponema pallidum pertenue. The disease begins with a round, hard swelling of the skin, 2 to 5 cm in diameter. The center may break open and form an ulcer. This initial skin lesion typically heals after 3–6 months. After weeks to years, joints and bones may become painful, fatigue may develop, and new skin lesions may appear. The skin of the palms of the hands and the soles of the feet may become thick and break open. The bones may become misshapen. After 5 years or more, large areas of skin may die, leaving scars.
Congenital syphilis is syphilis that occurs when a mother with untreated syphilis passes the infection to her baby during pregnancy or at birth. It may present in the fetus, infant, or later. Clinical features vary and differ between early onset, that is presentation before 2-years of age, and late onset, presentation after age 2-years. Infection in the unborn baby may present as poor growth, non-immune hydrops leading to premature birth or loss of the baby, or no signs. Affected newborns mostly initially have no clinical signs. They may be small and irritable. Characteristic features include a rash, fever, large liver and spleen, a runny and congested nose, and inflammation around bone or cartilage. There may be jaundice, large glands, pneumonia, meningitis, warty bumps on genitals, deafness or blindness. Untreated babies that survive the early phase may develop skeletal deformities including deformity of the nose, lower legs, forehead, collar bone, jaw, and cheek bone. There may be a perforated or high arched palate, and recurrent joint disease. Other late signs include linear perioral tears, intellectual disability, hydrocephalus, and juvenile general paresis. Seizures and cranial nerve palsies may first occur in both early and late phases. Eighth nerve palsy, interstitial keratitis and small notched teeth may appear individually or together; known as Hutchinson's triad.
Sir Jonathan Hutchinson, was an English surgeon, ophthalmologist, dermatologist, venereologist, and pathologist, who notably advocated for circumcision.
Bejel, or endemic syphilis, is a chronic skin and tissue disease caused by infection by the endemicum subspecies of the spirochete Treponema pallidum. Bejel is one of the "endemic treponematoses", a group that also includes yaws and pinta. Typically, endemic trepanematoses begin with localized lesions on the skin or mucous membranes. Pinta is limited to affecting the skin, whereas bejel and yaws are considered to be invasive because they can also cause disease in bone and other internal tissues.
William Stokes was an Irish physician, who was Regius Professor of Physic at Trinity College Dublin. He graduated from the University of Edinburgh Medical School with an MD in 1825 later returning the practice in Dublin at Meath Hospital. He went on to create two important works on cardiac and pulmonary diseases – A Treatise on the Diagnosis and Treatment of Diseases of the Chest (1837) and The Diseases of the Heart and Aorta (1854) – as well as one of the first treatises on the use of the stethoscope. He emphasised the importance of clinical examination in forming diagnoses, and of ward-based learning for students of medicine.
Philippe Ricord was a French physician.
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, idiopathic spontaneous abortion, and systemic lupus erythematosus (SLE). They are a form of anti-mitochondrial antibody. In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present individually or together; the two types of antibodies act independently. This is in contrast to rheumatoid arthritis with systemic sclerosis (scleroderma) because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together.
Abraham Buschke was a Jewish German dermatologist who was a native of Nakel in the Province of Posen.
Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and are often beneficial but others can cause infectious diseases. The number of these pathogenic species in humans is estimated to be fewer than a hundred. By contrast, several thousand species are part of the gut flora present in the digestive tract.
A sexually transmitted infection (STI), also referred to as a sexually transmitted disease (STD) and the older term venereal disease (VD), is an infection that is spread by sexual activity, especially vaginal intercourse, anal sex, oral sex, or sometimes manual sex. STIs often do not initially cause symptoms, which results in a risk of transmitting them on to others. The term sexually transmitted infection is generally preferred over sexually transmitted disease or venereal disease, as it includes cases with no symptomatic disease. Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain. Some STIs can cause infertility.
A lock hospital was an establishment that specialised in treating sexually transmitted diseases. They operated in Britain and its colonies and territories from the 18th century to the 20th.
The first recorded outbreak of syphilis in Europe occurred in 1494/1495 in Naples, Italy, during a French invasion. Because it was spread geographically by French troops returning from that campaign, the disease was known as "French disease", and it was not until 1530 that the term "syphilis" was first applied by the Italian physician and poet Girolamo Fracastoro. The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann in 1905 at the Charité Clinic in Berlin. The first effective treatment, Salvarsan, was developed in 1910 by Sahachiro Hata in the laboratory of Paul Ehrlich. It was followed by the introduction of penicillin in 1943.
Friedrich Jacob Behrend was a German physician known for his published works, in particular, subjects dealing with sexually transmitted disease, public hygiene and prostitution. He is also credited with translating a number of foreign language medical works into German.
John Arthur Harland Hancock was a British venereologist and editor of the British Journal of Venereal Diseases who wrote on non-gonococcal urethritis and reactive arthritis, what was known as Reiter's disease at the time. In 1945, while studying medicine at the London Hospital, he was one of the voluntary students sent to Belsen to assist nutritionist Arnold Peter Meiklejohn in feeding the starving inmates. There, he became unwell with typhus and was treated back at The London by Lord Evans.
David Nunes Nabarro was a British physician who was the first bacteriologist at the Great Ormond Street Hospital for Children in London, and the hospital's first director of pathology. In 1903, he with David Bruce, Aldo Castellani and Cuthbert Christy established that sleeping sickness was caused by the blood parasite, Trypanosoma, and that it was transmitted by tsetse fly.
Annales des Maladies de la Peau et de la Syphilis was a French medical journal established in 1843 by Pierre Cazenave. In 1844 it published the first account of pemphigus foliaceus, written by Cazenave. Most issues were his works and its contents reflect a summary of his career in general.
References
- ↑ Powell, Frank C (June 2006). "William Wallace and transmission of syphilis: a forgotten villain?" . The Lancet. 367 (9525): 1818. doi:10.1016/S0140-6736(06)68801-6. PMID 16753483. S2CID 27653911.
- ↑ Kampmeier, R. H. (1980). "The introduction of iodine in the treatment of syphilis: the writings of William Wallace, M.D., of Dublin". Sexually Transmitted Diseases. 7 (1): 26–28. doi: 10.1097/00007435-198001000-00008 . ISSN 0148-5717. PMID 6994258.
- ↑ Widdess, J. D. H (1965). "William Wallace". British Journal of Venereal Diseases. 65 (9): 9–14. doi:10.1136/sti.41.1.9. PMC 1047692 . PMID 14275963.
- ↑ "A Treatise on the Venereal Disease and Its Varieties". The Medico-Chirurgical Review. 19 (38): 372–414. 1 October 1833. PMC 5086970 . PMID 29918030.
- ↑ Morton, R. S (January 1966). "Dr. William Wallace (1791-1837) of Dublin" (PDF). Medical History. 10 (1). Cambridge University Press: 38–43. doi:10.1017/s0025727300010620. PMID 5324024. S2CID 32390083.
 | This biographical article related to medicine is a stub. You can help Wikipedia by expanding it. |