YSI 2300 STAT PLUS Glucose and Lactate Analyzer

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The YSI 2300 STAT PLUS Glucose and Lactate Analyzer (YSI 2300) was a Class II in-vitro diagnostics (IVD) automated analyser intended that measured glucose in whole blood, plasma or serum; and of L-lactate in whole blood, plasma, or cerebrospinal fluid (CSF). In whole blood or plasma, the instrument could measure glucose and L-lactate simultaneously. [1] The analyzer was discontinued on 22 July 2021.

Prior to its discontinuation, the analyzer was widely accepted as the de facto standard for reference measurements and system calibration by most manufacturers of glucometers for the past 30 years, despite there being no such regulatory requirement. [2] [3] [4] [5] [6]

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Hypoglycemia, also called low blood sugar, is a fall in blood sugar to levels below normal, typically below 70 mg/dL (3.9 mmol/L). Whipple's triad is used to properly identify hypoglycemic episodes. It is defined as blood glucose below 70 mg/dL (3.9 mmol/L), symptoms associated with hypoglycemia, and resolution of symptoms when blood sugar returns to normal. Hypoglycemia may result in headache, tiredness, clumsiness, trouble talking, confusion, fast heart rate, sweating, shakiness, nervousness, hunger, loss of consciousness, seizures, or death. Symptoms typically come on quickly.

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A glucose meter, also referred to as a "glucometer", is a medical device for determining the approximate concentration of glucose in the blood. It can also be a strip of glucose paper dipped into a substance and measured to the glucose chart. It is a key element of glucose testing, including home blood glucose monitoring (HBGM) performed by people with diabetes mellitus or hypoglycemia. A small drop of blood, obtained from slightly piercing a fingertip with a lancet, is placed on a disposable test strip that the meter reads and uses to calculate the blood glucose level. The meter then displays the level in units of mg/dL or mmol/L.

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Google Contact Lens was a smart contact lens project announced by Google on 16 January 2014. The project aimed to assist people with diabetes by constantly measuring the glucose levels in their tears. The project was being carried out by Verily and as of 2014 was being tested using prototypes. On November 16, 2018, Verily announced it had discontinued the project.

The Ames Reflectance Meter was the first blood glucose meter. It allowed patients with diabetes to self-monitor their blood glucose levels.

References

  1. "User's Manual YSI 2300 STAT PLUS Glucose & L-Lactate Analyzer" (PDF). YSI. 2009.
  2. Bailey, Timothy S.; Klaff, Leslie J.; Wallace, Jane F.; Greene, Carmine; Pardo, Scott; Harrison, Bern; Simmons, David A. (July 2016). "Fundamental Importance of Reference Glucose Analyzer Accuracy for Evaluating the Performance of Blood Glucose Monitoring Systems (BGMSs)". Journal of Diabetes Science and Technology. 10 (4): 872–875. doi: 10.1177/1932296816634356 . PMC   4928230 . PMID   26902794.
  3. Han, Julia; Heinemann, Lutz; Ginsberg, Barry H.; Alva, Shridhara; Appel, Matthias; Bess, Stephan; Chen, Kong Y.; Freckmann, Guido; Harris, Dennis R.; Hartwig, Matthias; Hinzmann, Rolf; Kerr, David; Krouwer, Jan; Morrow, Linda; Nichols, James; Pfützner, Andreas; Pleus, Stefan; Rice, Mark; Sacks, David B.; Schlueter, Kevin; Vesper, Hubert W.; Klonoff, David C. (May 2020). "The YSI 2300 Analyzer Replacement Meeting Report". Journal of Diabetes Science and Technology. 14 (3): 679–686. doi: 10.1177/1932296820911471 . PMC   7576944 . PMID   32174135.
  4. "Glucose Analytical Comparability Evaluation of the YSI 2300 STAT Plus™ and YSI 2900D Biochemistry Analyzers" (PDF). YSI.
  5. Han, Julia; Nichols, James H.; Rice, Mark; Klonoff, David C. (May 2020). "The End of the Road for the YSI 2300 Analyzer: Where Do We Go Now?". Journal of Diabetes Science and Technology. 14 (3): 595–600. doi: 10.1177/1932296819886603 . PMC   7576956 . PMID   31711305.
  6. Hagvik, Joakim (March 2007). "Glucose Measurement: Time for a Gold Standard". Journal of Diabetes Science and Technology. 1 (2): 169–172. doi: 10.1177/193229680700100205 . PMC   2771464 . PMID   19888402.

Further reading