Yehuda Shoenfeld

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Yehuda Shoenfeld
An interview with Yehuda Shoenfeld on Autoimmune Syndrome induced by Adjuvants (ASIA)

Yehuda Shoenfeld (born February 14, 1948) [1] is an Israeli physician and autoimmunity researcher.

Israel country in the Middle East

Israel, officially the State of Israel, is a country in Western Asia, located on the southeastern shore of the Mediterranean Sea and the northern shore of the Red Sea. It has land borders with Lebanon to the north, Syria to the northeast, Jordan on the east, the Palestinian territories of the West Bank and Gaza Strip to the east and west, respectively, and Egypt to the southwest. The country contains geographically diverse features within its relatively small area. Israel's economic and technological center is Tel Aviv, while its seat of government and proclaimed capital is Jerusalem, although the state's sovereignty over Jerusalem has only partial recognition.

Physician professional who practices medicine

A physician, medical practitioner, medical doctor, or simply doctor, is a professional who practises medicine, which is concerned with promoting, maintaining, or restoring health through the study, diagnosis, prognosis and treatment of disease, injury, and other physical and mental impairments. Physicians may focus their practice on certain disease categories, types of patients, and methods of treatment—known as specialities—or they may assume responsibility for the provision of continuing and comprehensive medical care to individuals, families, and communities—known as general practice. Medical practice properly requires both a detailed knowledge of the academic disciplines, such as anatomy and physiology, underlying diseases and their treatment—the science of medicine—and also a decent competence in its applied practice—the art or craft of medicine.

Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues. Any disease that results from such an aberrant immune response is termed an "autoimmune disease". Prominent examples include celiac disease, diabetes mellitus type 1, sarcoidosis, systemic lupus erythematosus (SLE), Sjögren's syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis (RA), ankylosing spondylitis, polymyositis (PM), dermatomyositis (DM) and multiple sclerosis (MS). Autoimmune diseases are very often treated with steroids.



Yehuda Shoenfeld works at Sheba Medical Center in Tel HaShomer and the Sackler Faculty of Medicine at Tel-Aviv University. He studied at the Hebrew University of Jerusalem. He is the incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases. Shoenfeld is the editor of two journals, Harefuah (Medicine) in Hebrew with English abstracts and Israel Medical Association Journal (IMAJ). He is co-editor-in-chief of Autoimmunity Reviews , [2] and co-editor of the Journal of Autoimmunity , [3] and member of the editorial board of the Clinical Reviews in Allergy & Immunology. [4]

Sheba Medical Center Hospital in Ramat Gan, Israel

The Chaim Sheba Medical Center at Tel HaShomer, also Tel HaShomer Hospital, is the largest hospital in Israel, located in the Tel HaShomer neighborhood of Ramat Gan, in the Tel Aviv District. In 2019, Newsweek ranked it as the 10th-best hospital in the world.

Tel HaShomer Neighborhood of Ramat Gan in Ramat Gan, Israel

Tel HaShomer or Kiryat Krinitzi is a Neighborhood in Ramat Gan, Israel. It is bordered to the north by Kiryat Ono, to the east by Yehud, and to the south by Or Yehuda. A major Israel Defense Forces base and the Sheba Medical Center are located in Tel HaShomer.

Sackler Faculty of Medicine medical school of Tel Aviv University, located in Tel Aviv, Israel

Sackler Faculty of Medicine is a medical school affiliated with Tel Aviv University, located in Tel Aviv, Israel.

Published works

While two of Shoenfeld's scientific articles have been retracted, [5] [6] he has published more than 1920 papers. Also, he has authored and edited 40 books and contributed more than 350 chapters to various books, most recently Vaccines and Autoimmunity published by Wiley Blackwell. Prof. Shoenfeld is on the editorial board of 43 medical journals. [7]

Awards and recognition

Shoenfeld received the EULAR Prize (Austria, 2005). He received the Nelson’s Prize for Humanity and Science from U.C. Davis (U.S., 2008). He was honored as Doctoris Honoris Causa by Debrecen University (Hungary, 2009). He has awarded a Life Contribution Prize in Internal Medicine (Israel, 2012), as well as the ACR Master Award (U.S., 2013). He is an honorary member of the Hungarian Association of Rheumatology, Slovenian National Academy of Sciences and the Royal Society of Physicians (UK). [7]

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An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases. Nearly any body part can be involved. Common symptoms include low grade fever and feeling tired. Often symptoms come and go.

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Bonita Sue "Bonnie" Dunbar is a former professor in the department of molecular and cell biology at Baylor College of Medicine, a position she held from 1994 to 2004. Prior thereto she was an assistant professor in the same department at the same university from 1981 to 1983. From 1984 to 1994, also at Baylor College of Medicine, she also held a position as associate professor in the department of obstetrics and gynecology. She is currently an honorary lecturer at the University of Nairobi. She is a member of the American Association for the Advancement of Science, the Endocrine Society, the American Society for Cell Biology, and the New York Academy of Sciences. She is currently the owner of the Karen Blixen Coffee Garden Restaurant and Cottages, as well as the treasurer of the African Biomedical Center. She also served on the editorial board of the journal Medical Veritas, which was published from 2004 to 2008 and endorsed anti-vaccine views.

Autoimmune/inflammatory syndrome induced by adjuvants, also known as Shoenfeld's syndrome or ASIA, is a theoretical autoimmune disorder proposed by Israeli immunologist Yehuda Shoenfeld in 2011. According to Shoenfeld, the syndrome includes four conditions: "post-vaccination symptoms," macrophagic myofasciitis, Gulf war syndrome, sick building syndrome, and siliconosis. Shoenfeld alleges that the syndrome is caused by adjuvants such as silicone, tetramethylpentadecane, pristane, and aluminum. However, causality is difficult to prove because ASIA only occurs in a small fraction of patients exposed to these adjuvants. Additionally, proponents of this theory allege that the disorder can manifest anywhere from 2 days to 23 years after exposure. Shoenfeld has also named Sjögren's syndrome as potentially being another facet of ASIA. In 2013, the authors of a textbook on autoimmune diseases concluded that "there exists persuasive evidence for ASIA," but noted that several academic and governmental agencies had dismissed the possibility of a link between silicone and autoimmune disease.

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  1. "Yehuda Shoenfeld Curriculum Vitae" (PDF). WAIDID. Retrieved 23 February 2019.
  2. "Autoimmunity Reviews" via
  3. "Journal of Autoimmunity - Editorial Board". Elsevier. Retrieved 5 March 2019.
  5. Inbar, Rotem; Weiss, Ronen; Tomljenovic, Lucija; Arango, Maria-Teresa; Deri, Yael; Shaw, Christopher A.; Chapman, Joab; Blank, Miri; Shoenfeld, Yehuda (2016). "WITHDRAWN: Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil". Vaccine. doi:10.1016/j.vaccine.2015.12.067. PMID   26778424.
  6. Blank, Miri; Matthias, Torsten; Chapman, Joab; Harel-Meir, Michal; Slutsky, Inna; Zusev, Margalit; O’Kane, Sara Louise; Cahill, Dolores J.; Arango, Maria-Teresa; Shoenfeld, Yehuda; Kivity, Shaye (1 October 2017). "Retracted: Anti-ribosomal-phosphoprotein autoantibodies penetrate to neuronal cells via neuronal growth associated protein, affecting neuronal cells in vitro". Rheumatology. 56 (10): 1827. doi:10.1093/rheumatology/kex259. PMID   28957569 via
  7. 1 2 "2016 Symposium Advances in Autoimmunity" (PDF). Retrieved 5 March 2019.