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Yissum Research Development Company (commonly referred to as Yissum) is the technology transfer company of the Hebrew University of Jerusalem. Established in 1964, Yissum is one of the world's third technology transfer organizations, facilitating the commercialization of innovative research and technologies developed by the university's researchers [1] .
Yissum connects researchers with industry leaders, entrepreneurs, and investors, enabling the transfer of academic knowledge to the marketplace. It has contributed to the establishment of numerous successful companies and the development of groundbreaking technologies across diverse fields, including biotechnology, agriculture, nanotechnology, and artificial intelligence.
Yissum was founded in 1964 [2] to bridge the gap between academic research and industry. Over the decades, the company has managed thousands of patents, technology licenses, and spin-off companies originating from research [3] conducted at the Hebrew University of Jerusalem.
Prominent technologies that originated from Yissum include the development of the Exelon drug [4] for Alzheimer's disease, Doxil for cancer treatment [5] , and agricultural innovations like seed breeding for improved crops [6] .
In January 2025, Alon Natanson was appointed as the Chief Executive Officer of Yissum, succeeding Dr. Itzik Goldwaser, who led the company for 15 years [7] . Natanson, an alumnus of the Hebrew University, brings extensive experience in transforming life sciences and technology companies, including roles at Nonagon Ltd., Apos Medical Assets, and Brainstorm Cell Therapeutics. [8]
Yissum has played a pivotal role in founding numerous companies, including:
FuturaGene (2000) – Specializing in genetically enhanced trees for the forestry and biofuel industries [9] . CollPlant (2004) – Developing plant-based recombinant collagen for regenerative medicine [10] . BioBetter (2015) – Producing growth factors for cultivated meat using tobacco plants [11] . Melodea (2010) – Creating sustainable cellulose-based materials for packaging [12] .
Yissum's portfolio spans a wide range of industries, including:
Life Sciences and Biotechnology – Developing treatments for diseases, medical devices, and biotechnological applications. Agriculture and Food Technology – Innovations in crop improvement, food safety, and sustainable food production. Nanotechnology and Materials – Research on advanced materials and nanotechnological applications. Computer Science and Artificial Intelligence – Developing algorithms, machine learning models, and software technologies. Impact
As of 2025, Yissum has registered over 12,000 patents, licensed more than 3,000 technologies, and facilitated the creation of over 250 spin-off companies. Its work has generated substantial economic impact, with products and technologies originating from Yissum used worldwide [13] .
The Technion – Israel Institute of Technology is a public research university located in Haifa, Israel. Established in 1912 by Jews under the dominion of the Ottoman Empire, the Technion is the oldest university in the country.
The Hebrew University of Jerusalem is an Israeli public research university based in Jerusalem. Co-founded by Albert Einstein and Chaim Weizmann in July 1918, the public university officially opened on 1 April 1925. It is the second-oldest Israeli university, having been founded 30 years before the establishment of the State of Israel but six years after the older Technion university. The HUJI has three campuses in Jerusalem, one in Rehovot, one in Rishon LeZion and one in Eilat. Until 2023, the world's largest library for Jewish studies—the National Library of Israel—was located on its Edmond J. Safra campus in the Givat Ram neighbourhood of Jerusalem.
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Rivastigmine, sold under the brand name Exelon among others, is an acetylcholinesterase inhibitor used for the treatment of dementia associated with Alzheimer's disease and with Parkinson's disease. Rivastigmine can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting.
Menachem Lewin, was an Israeli chemist. Lewin worked in polymer, fiber and nanotechnology research. Until his death, a month before his 93rd birthday, Lewin was in charge of a research program at the Polytechnic Institute of New York University. In 2009, he was appointed as editor-in-chief of the Encyclopedia on Fiber science and Engineering, to be published by Wiley in New York. Lewin obtained 29 U.S. and European patents and published 175 peer-reviewed publications. He was the founder (1990) and editor-in-chief of the international monthly journal Polymers for Advanced Technologies (PAT). PAT sponsors international biannual symposia for scientists, and Lewin often served as chairman, co-chairman or honorary chairman.
T3 Technion Technology Transfer is the technology transfer unit of the Technion – Israel Institute of Technology in Israel. The unit operates under the auspices of the Technion Research & Development Foundation.
BioLineRx Ltd., or BioLine, is a publicly traded drug development company. Headquartered in Israel, its shares are traded on the NASDAQ Capital Market and on the Tel Aviv Stock Exchange.
The Jerusalem Development Authority, or JDA, is a joint agency of the Israeli government and the Jerusalem Municipality that works to promote and develop the economy of the city of Jerusalem. The Authority was founded by Uziel Wexler and was established as a statutory corporation under the Jerusalem Development Authority Law 1988. Teddy Kollek was one of the key figures behind its establishment.
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