| 2010 Soweto Open | |
|---|---|
| Date | 12–18 April |
| Edition | 2nd |
| Location | Johannesburg, South Africa |
| 2009 Champions | |
| Singles | |
 Dustin Brown | |
| Doubles | |
 Nicolas Mahut /  Lovro Zovko | |
The 2010 Soweto Open was a professional tennis tournament played on hard courts. It was part of the 2010 ATP Challenger Tour. It took place in Johannesburg, South Africa between 12 and 18 April 2010.
| Nationality | Player | Ranking* | Seeding |
|---|---|---|---|
 SVK | Lukáš Lacko | 63 | 1 |
| SVK | Karol Beck | 78 | 2 |
 TPE | Lu Yen-hsun | 98 | 3 |
 ISR | Harel Levy | 125 | 4 |
| JAM | Dustin Brown | 126 | 5 |
 SUI | Stéphane Bohli | 140 | 6 |
 SLO | Grega Žemlja | 144 | 7 |
 NED | Igor Sijsling | 162 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Dustin Brown def. 
Izak van der Merwe, 7–6(2), 6–3
Nicolas Mahut / Lovro Zovko def. Raven Klaasen / Izak van der Merwe, 6–2, 6–2
