AOC2

Last updated
AOC2
Identifiers
Aliases AOC2 , DAO2, RAO, amine oxidase, copper containing 2, SSAO, amine oxidase copper containing 2
External IDs OMIM: 602268 MGI: 2668431 HomoloGene: 56457 GeneCards: AOC2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009590
NM_001158

NM_178932

RefSeq (protein)

NP_001149
NP_033720

NP_849263

Location (UCSC) Chr 17: 42.84 – 42.85 Mb Chr 11: 101.33 – 101.33 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Amine oxidase, copper containing 2 (AOC2) is a protein that in humans is encoded by the AOC2 gene. [5] The protein is a copper-containing primary amine oxidase enzyme.

Contents

Function

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

Related Research Articles

Diamine oxidase

Diamine oxidase (DAO), also known "amine oxidase, copper-containing, 1" (AOC1), formerly called histaminase, is an enzyme involved in the metabolism, oxidation, and inactivation of histamine and other polyamines such as putrescine or spermidine in animals. It belongs to the amine oxidase (copper-containing) (AOC) family of amine oxidase enzymes. In humans, DAO it is encoded by AOC1 gene.

GPR82

Probable G-protein coupled receptor 82 is a protein that in humans is encoded by the GPR82 gene.

GPR62

Probable G-protein coupled receptor 62 is a protein that in humans is encoded by the GPR62 gene.

Probable low affinity copper uptake protein 2

Probable low affinity copper uptake protein 2 is a protein that in humans is encoded by the SLC31A2 gene.

TAAR8

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene. In humans, TAAR8 is the only trace amine-associated receptor that is known to be Gi/o-coupled.

TAAR9

Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.

ARID3B

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.

OR5H2

Olfactory receptor 5H2 is a protein that in humans is encoded by the OR5H2 gene.

OR52R1

Olfactory receptor 52R1 is a protein that in humans is encoded by the OR52R1 gene.

OR2AK2

Olfactory receptor 2AK2 is a protein that in humans is encoded by the OR2AK2 gene.

OR4M1

Olfactory receptor 4M1 is a protein that in humans is encoded by the OR4M1 gene.

LOXL4

Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene.

PAOX

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene.

GPR61

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.

LOXL3

Lysyl oxidase homolog 3 is an enzyme that in humans is encoded by the LOXL3 gene.

BHLHA9

Basic helix-loop-helix family, member a9 is a protein in humans that is encoded by the BHLHA9 gene.

CAMK1D

Calcium/calmodulin-dependent protein kinase ID is a protein in humans that is encoded by the CAMK1D gene on chromosome 10.

COX6B2

Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.

GMCL1

Germ cell-less, spermatogenesis associated 1 is a protein that in humans is encoded by the GMCL1 gene.

OXA1L

Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2. The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131480 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078651 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Amine oxidase, copper containing 2" . Retrieved 2015-12-31.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.