ASB1

ASB1
Identifiers
Aliases	ASB1 , ASB-1, ankyrin repeat and SOCS box containing 1
External IDs	OMIM: 605758 MGI: 1929735 HomoloGene: 9390 GeneCards: ASB1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,452,250 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,487,311 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; putamen; ; amygdala; ; left ventricle; ; hypothalamus; ; substantia nigra; ; caudate nucleus; ; cingulate gyrus; ; internal globus pallidus; ; anterior pituitary;
	Top expressed in
	blood; ; otolith organ; ; utricle; ; seminiferous tubule; ; supraoptic nucleus; ; yolk sac; ; spermatocyte; ; substantia nigra; ; spermatid; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; ubiquitin protein ligase activity ;
Cellular component	cytosol ; ubiquitin ligase complex ;
Biological process	multicellular organism development ; intracellular signal transduction ; male genitalia development ; post-translational protein modification ; protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	51665
	65247
	ENSG00000065802
	ENSMUSG00000026311
	Q9Y576
	Q9WV74
	NM_001040445 ; NM_016114 ; NM_001330196
	NM_001039126 ; NM_023046
	NP_001035535 ; NP_001317125
	NP_001034215 ; NP_075533
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene.^[5]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.^[5]

Related Research Articles

Elongin A is a protein that in humans is encoded by the ELOA gene.

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.

SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.

Ras-related protein Rab-40A is a protein that in humans is encoded by the RAB40A gene.

KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene.

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.

Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.

Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene. This protein has a function that is not currently understood.

Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene.

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene.

Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 is a protein that in humans is encoded by the ASZ1 gene.

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.

Neuralized-like protein 2 is a protein that in humans is encoded by the NEURL2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065802 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026311 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ASB1 ankyrin repeat and SOCS box-containing 1".

External links

Human ASB1 genome location and ASB1 gene details page in the UCSC Genome Browser .

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336 . PMID 11509662.
Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID 10574461.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000065802 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026311 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ASB1 ankyrin repeat and SOCS box-containing 1".

[1]

[2]

[3]

[4]

[5]

ASB1

Contents

Related Research Articles

References

External links

Further reading