ATP5G2

ATP5MC2
Identifiers
Aliases	ATP5MC2 , ATP5A, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9), ATP synthase membrane subunit c locus 2, ATP5G2
External IDs	OMIM: 603193 MGI: 1915192 HomoloGene: 57052 GeneCards: ATP5MC2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,677,408 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,580,787 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; islet of Langerhans; ; right uterine tube; ; anterior pituitary; ; body of stomach; ; embryo; ; right adrenal gland; ; ganglionic eminence; ; left ventricle; ; body of pancreas;
	Top expressed in
	embryo; ; quadriceps femoris muscle; ; neural tube; ; stomach; ; esophagus; ; yolk sac; ; proximal tubule; ; blastocyst; ; mesencephalon; ; ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	proton transmembrane transporter activity ; lipid binding ; transporter activity ; proton-transporting ATP synthase activity, rotational mechanism ; protein binding ;
Cellular component	proton-transporting ATP synthase complex, coupling factor F(o) ; integral component of membrane ; mitochondrial outer membrane ; proton-transporting two-sector ATPase complex, proton-transporting domain ; mitochondrial proton-transporting ATP synthase complex ; membrane ; mitochondrion ; mitochondrial membrane ; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ;
Biological process	ion transport ; ATP biosynthetic process ; ATP synthesis coupled proton transport ; cristae formation ; mitochondrial ATP synthesis coupled proton transport ;
	Sources:Amigo / QuickGO
Orthologs
	517
	67942
	ENSG00000135390
	ENSMUSG00000062683
	Q06055
	P56383
	NM_001002031 ; NM_005176 ; NM_001330269
	NM_026468
NP_001002031 ; NP_001317198 ; NP_005167 ; NP_001356682 ; NP_001356683 ;
	NP_001356684 ; NP_001356685 ; NP_001356686 ; NP_001356687 Contents References ; External links ; Further reading ;
	NP_080744
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.^[5]^[6]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.^[6]

Related Research Articles

MT-ATP8 is a mitochondrial gene with the full name 'mitochondrially encoded ATP synthase membrane subunit 8' that encodes a subunit of mitochondrial ATP synthase, ATP synthase F_o subunit 8. This subunit belongs to the F_o complex of the large, transmembrane F-type ATP synthase. This enzyme, which is also known as complex V, is responsible for the final step of oxidative phosphorylation in the electron transport chain. Specifically, one segment of ATP synthase allows positively charged ions, called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Subunit 8 differs in sequence between Metazoa, plants and Fungi.

MT-ATP6 is a mitochondrial gene with the full name 'mitochondrially encoded ATP synthase membrane subunit 6' that encodes the ATP synthase F_o subunit 6. This subunit belongs to the F_o complex of the large, transmembrane F-type ATP synthase. This enzyme, which is also known as complex V, is responsible for the final step of oxidative phosphorylation in the electron transport chain. Specifically, one segment of ATP synthase allows positively charged ions, called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Mutations in the MT-ATP6 gene have been found in approximately 10 to 20 percent of people with Leigh syndrome.

ATP synthase F1 subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5F1B gene.

ATP synthase F1 subunit alpha, mitochondrial is an enzyme that in humans is encoded by the ATP5F1A gene.

ATP synthase-coupling factor 6, mitochondrial is an enzyme subunit that in humans is encoded by the ATP5PF gene.

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.

The ATP5MF gene encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene.

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.

ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene.

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

ATP synthase subunit delta, mitochondrial, also known as ATP synthase F1 subunit delta or F-ATPase delta subunit is an enzyme that in humans is encoded by the ATP5F1D gene. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation.

ATP synthase F1 subunit epsilon, mitochondrial is an enzyme that in humans is encoded by the ATP5F1E gene. The protein encoded by ATP5F1E is a subunit of ATP synthase, also known as Complex V. Variations of this gene have been associated with mitochondrial complex V deficiency, nuclear 3 (MC5DN3) and Papillary Thyroid Cancer.

The ATP5MC3 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135390 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062683 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dyer MR, Walker JE (Aug 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". Biochem J. 293 (1): 51–64. doi:10.1042/bj2930051. PMC 1134319 . PMID 8328972.
1 2 "Entrez Gene: ATP5MC2 ATP synthase membrane subunit c locus 2".

External links

Human ATP5MC2 genome location and ATP5MC2 gene details page in the UCSC Genome Browser .

Farrell LB, Nagley P (1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex". Biochem. Biophys. Res. Commun. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
Yan WL, Lerner TJ, Haines JL, Gusella JF (1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
Houstĕk J, Andersson U, Tvrdík P, et al. (1995). "The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue". J. Biol. Chem. 270 (13): 7689–94. doi: 10.1074/jbc.270.13.7689 . PMID 7706317.
Higuti T, Kawamura Y, Kuroiwa K, et al. (1993). "Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria". Biochim. Biophys. Acta. 1173 (1): 87–90. doi:10.1016/0167-4781(93)90249-D. PMID 8485160.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi: 10.1038/427407b . PMID 14749816. S2CID 52819856.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135390 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062683 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8328972-5] Dyer MR, Walker JE (Aug 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". Biochem J. 293 (1): 51–64. doi:10.1042/bj2930051. PMC 1134319 . PMID 8328972.

[entrez-6] 1 2 "Entrez Gene: ATP5MC2 ATP synthase membrane subunit c locus 2".

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ATP5G2

Contents

Related Research Articles

References

External links

Further reading