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| Identifiers | |
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3D model (JSmol) | |
PubChem CID | |
| UNII | |
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| Properties | |
| C40H60BNaO14 | |
| Molar mass | 798.71 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Aplasmomycin is an antibiotic with antimalarial activity isolated from Streptomycete . [1]
Streptomyces is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin.
David Gottlieb (1911–1982), a professor of plant pathology at the University of Illinois at Urbana-Champaign (1946–1982), was a pioneer in the field of fungal physiology and antibiotics for plants.
Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases. Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.
Ribostamycin is an aminoglycoside-aminocyclitol antibiotic isolated from a streptomycete, Streptomyces ribosidificus, originally identified in a soil sample from Tsu City of Mie Prefecture in Japan. It is made up of 3 ring subunits: 2-deoxystreptamine (DOS), neosamine C, and ribose. Ribostamycin, along with other aminoglycosides with the DOS subunit, is an important broad-spectrum antibiotic with important use against human immunodeficiency virus and is considered a critically important antimicrobial by the World Health Organization., Resistance against aminoglycoside antibiotics, such as ribostamycin, is a growing concern. The resistant bacteria contain enzymes that modify the structure through phosphorylation, adenylation, and acetylation and prevent the antibiotic from being able to interact with the bacterial ribosomal RNAs.
Streptomyces griseus is a species of bacteria in the genus Streptomyces commonly found in soil. A few strains have been also reported from deep-sea sediments. It is a Gram-positive bacterium with high GC content. Along with most other streptomycetes, S. griseus strains are well known producers of antibiotics and other such commercially significant secondary metabolites. These strains are known to be producers of 32 different structural types of bioactive compounds. Streptomycin, the first antibiotic ever reported from a bacterium, comes from strains of S. griseus. Recently, the whole genome sequence of one of its strains had been completed.
Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin. Pristinamycin IIA was first isolated from the Streptomyces virginiae, but has been isolated from other microorganisms and thus has been given a variety of other names such as Virginiamycin M1, Mikamycin A, and Streptogramin A. Pristinamycin IIA structure was determined by chemical and instrumental techniques, including X-ray crystallography. Pristinamycin IIA is of interest from a biosynthetic viewpoint because it contains the unusual dehydroproline and oxazole ring systems. The only experimental evidence bearing on the formation of the oxazole ring is found in work on the biosynthesis of the alkaloid annuloline.
Streptomyces avermitilis is a species of bacteria in the genus Streptomyces. This bacterium was discovered by Satoshi Ōmura in Shizuoka Prefecture, Japan.
Albomycins are a group of naturally occurring antibiotics belonging to the class of sideromycins, which are "compounds composed of iron carriers called siderophores linked to antibiotic moieties". They are particularly effective against Gram-negative bacteria of the family Enterobacteriaceae and few Gram-positive bacteria such s Streptococcus pneumoniae, Bacillus subtilis and Staphylococcus aureus. In 2000 a group of scientists from SmithKline Beecham Pharmaceuticals, UK reported that the antibiotic part of albomycin in vitro can inhibit seryl t-RNA synthetase from both eukaryotic and prokaryotic representatives.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of Actinomycetota, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium.
Mervyn James Bibb FRS is an Emeritus Fellow at the John Innes Centre, Norwich, UK.
Streptomyces albidoflavus is a bacterium species from the genus of Streptomyces which has been isolated from soil from Poland. Streptomyces albidoflavus produces dibutyl phthalate and streptothricins.
Streptomyces cirratus is a bacterium species from the genus of Streptomyces. Streptomyces cirratus produces phegomycin, phegomycin D, phegomycin DGPT, cirratiomycin A, cirramycin A and cirramycin B.'
Streptomyces griseorubiginosus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Russia. Streptomyces griseorubiginosus produces arylsulfatase, biphenomycin A, cinerubin A and cinerubin B.
Streptomyces lacticiproducens is a bacterium species from the genus of Streptomyces which has been isolated from the rhizosphere of a tomato plant in Guangzhou in China. Streptomyces lacticiproducens produces lactic acid.
Streptomyces nigrescens is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces nigrescens produces 5-alkyl-1,2,3,4-tetrahydroquinolines and the antibiotics phoslactomycin A - F.
Streptomyces sanglieri is a bacterium species from the genus of Streptomyces which has been isolated from soil from a hay meadow. Streptomyces sanglieri produces the antibiotic lactonamycin Z.
Streptomyces scopuliridis is a bacterium species from the genus of Streptomyces which has been isolated from woodland soil from Rainbow Bluff in Lynn in Alabama in the United States. Streptomyces scopuliridis produces bacteriocins, desotamides B, desotamides C, desotamides D, sesquiterpenoids and herbicidins.
Streptomyces speibonae is a bacterium species from the genus of Streptomyces which has been isolated from soil from Cape Town in South Africa. Streptomyces speibonae produces the antibiotic oxytetracycline.
Streptomyces vietnamensis is a bacterium species from the genus of Streptomyces which has been isolated from forest soil in Vietnam.
Cytochrome P450 family 170 subfamily B member 1 is an actinobacterial Cytochrome P450 enzyme originally from Streptomyces albus, which catalyzes the biosynthesis of the tricyclic sesquiterpene antibiotic albaflavenone.
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