Ascaris

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Ascaris
Ascaris lumbricoides.jpeg
Adult female
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Nematoda
Class: Chromadorea
Order: Ascaridida
Family: Ascarididae
Genus: Ascaris
Linnaeus, 1758
Species
Ascaris lumbricoides life cycle.tif

Ascaris is a nematode genus of parasitic worms known as the "small intestinal roundworms", which is a type of parasitic worm. [1] One species, Ascaris lumbricoides , affects humans and causes the disease ascariasis. Another species, Ascaris suum , typically infects pigs. Other ascarid genera infect other animals, such as Parascaris equorum , the equine roundworm, and Toxocara and Toxascaris , which infect dogs and cats.

Contents

Their eggs are deposited in feces and soil. Plants with the eggs on them infect any organism that consumes them. [2] A. lumbricoides is the largest intestinal roundworm and is the most common helminth infection of humans worldwide. Infestation can cause morbidity by compromising nutritional status, [3] affecting cognitive processes, [4] inducing tissue reactions such as granuloma to larval stages, and by causing intestinal obstruction, which can be fatal.

Morphology

The body is long, cylindrical, and fusiform (pointed at both the ends). The body wall is composed of cuticle, epidermis and musculature. There is a pseudocoelom. Respiration is by simple diffusion. The nervous system consists of a nerve ring and many longitudinal nerve cords. Reproduction is exclusively sexual, and males are usually shorter than females.

Defense mechanism

As part of the parasite defense strategy, Ascaris roundworms secrete a series of inhibitors to target digestive and immune-related host proteases, which include pepsin, trypsin, chymotrypsin/elastase, cathepsins, and metallocarboxypeptidases (MCPs). Ascaris species inhibit MCPs by releasing an enzyme known as Ascaris carboxypeptidase inhibitor (ACI). This enzyme binds to the active site of MCP and blocks the cleavage of its own proteins by the host MCP. [5] Similarly, they inhibit trypsin by releasing the protein Ascaris Trypsin Inhibitor (pdb 1ATA). [6]

History

Ascaris has been present in humans for at least several thousand years, as evidenced by Ascaris eggs found in paleofeces and in the intestines of mummified humans. [7]

A. lumbricoides was originally called Lumbricus teres and was first described in detail by Edward Tyson in 1683. [8] The genus Ascaris was originally described as the genus for Ascaris lumbricoides by Carl Linnaeus in 1758. [9] The morphologically similar Ascaris suum was described from pigs by Johann August Ephraim Goeze in 1782. [9]

See also

Related Research Articles

<i>Ascaris lumbricoides</i> One of several species of Ascaris

Ascaris lumbricoides is a large parasitic worm that causes ascariasis in humans. A roundworm of genus Ascaris, it is the most common parasitic worm in humans. An estimated one-sixth of the human population is at some point infected by a roundworm such as A. lumbricoides; people living in tropical and subtropical countries are at greater risk of infection.

<i>Trichuris trichiura</i> Parasitic roundworm that causes intestinal infection

Trichuris trichiura, Trichocephalus trichiuris or whipworm, is a parasitic roundworm that causes trichuriasis when it infects a human large intestine. It is commonly known as the whipworm which refers to the shape of the worm; it looks like a whip with wider "handles" at the posterior end.

<span class="mw-page-title-main">Trichuriasis</span> Infection by Trichuris trichiura (whipworm)

Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris trichiura (whipworm). If infection is only with a few worms, there are often no symptoms. In those who are infected with many worms, there may be abdominal pain, fatigue and diarrhea. The diarrhea sometimes contains blood. Infections in children may cause poor intellectual and physical development. Low red blood cell levels may occur due to loss of blood.

<span class="mw-page-title-main">Parasitology</span> Study of parasites, their hosts, and the relationship between them

Parasitology is the study of parasites, their hosts, and the relationship between them. As a biological discipline, the scope of parasitology is not determined by the organism or environment in question but by their way of life. This means it forms a synthesis of other disciplines, and draws on techniques from fields such as cell biology, bioinformatics, biochemistry, molecular biology, immunology, genetics, evolution and ecology.

<span class="mw-page-title-main">Ascariasis</span> Disease caused by the parasitic roundworm Ascaris lumbricoides

Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no symptoms in more than 85% of cases, especially if the number of worms is small. Symptoms increase with the number of worms present and may include shortness of breath and fever in the beginning of the disease. These may be followed by symptoms of abdominal swelling, abdominal pain, and diarrhea. Children are most commonly affected, and in this age group the infection may also cause poor weight gain, malnutrition, and learning problems.

<span class="mw-page-title-main">Helminthiasis</span> Any macroparasitic disease caused by helminths

Helminthiasis, also known as worm infection, is any macroparasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as helminths. There are numerous species of these parasites, which are broadly classified into tapeworms, flukes, and roundworms. They often live in the gastrointestinal tract of their hosts, but they may also burrow into other organs, where they induce physiological damage.

<i>Ascaris suum</i> Species of roundworm

Ascaris suum, also known as the large roundworm of pig, is a parasitic nematode that causes ascariasis in pigs. While roundworms in pigs and humans are today considered as two species with different hosts, cross-infection between humans and pigs is possible; some researchers have thus argued they are the same species. Ascariasis is associated with contact to pigs and pig manure in Denmark.

<span class="mw-page-title-main">Parasitic worm</span> Large type of parasitic organism

Parasitic worms, also known as helminths, are large macroparasites; adults can generally be seen with the naked eye. Many are intestinal worms that are soil-transmitted and infect the gastrointestinal tract. Other parasitic worms such as schistosomes reside in blood vessels.

<span class="mw-page-title-main">Helminthic therapy</span> Deliberate infestation with parasitic worms

Helminthic therapy, an experimental type of immunotherapy, is the treatment of autoimmune diseases and immune disorders by means of deliberate infestation with a helminth or with the eggs of a helminth. Helminths are parasitic worms such as hookworms, whipworms, and threadworms that have evolved to live within a host organism on which they rely for nutrients. These worms are members of two phyla: nematodes, which are primarily used in human helminthic therapy, and flat worms (trematodes).

Visceral larva migrans (VLM) is a condition in humans caused by the migratory larvae of certain nematodes, humans being a dead-end host, and was first reported in 1952. Nematodes causing such zoonotic infections are Baylisascaris procyonis, Toxocara canis, Toxocara cati, and Ascaris suum. These nematodes can infect but not mature in humans and after migrating through the intestinal wall, travel with the blood stream to various organs where they cause inflammation and damage. Affected organs can include the liver, heart and the CNS. A special variant is ocular larva migrans where usually T. canis larvae travel to the eye.

The soil-transmitted helminths are a group of intestinal parasites belonging to the phylum Nematoda that are transmitted primarily through contaminated soil. They are so called because they have a direct life cycle which requires no intermediate hosts or vectors, and the parasitic infection occurs through faecal contamination of soil, foodstuffs and water supplies. The adult forms are essentially parasites of humans, causing soil-transmitted helminthiasis (STH), but also infect domesticated mammals. The juveniles are the infective forms and they undergo tissue-migratory stages during which they invade vital organs such as lungs and liver. Thus the disease manifestations can be both local and systemic. The geohelminths together present an enormous infection burden on humanity, amounting to 135,000 deaths every year, and persistent infection of more than two billion people.

<span class="mw-page-title-main">Spiruria</span> Subclass of roundworms

Subclass Spiruria comprises mostly parasitic secernentean nematodes. In an alternate classification, they are treated as suborder Spirurina, with the orders listed here being ranked as infraorders.

<span class="mw-page-title-main">Ascarididae</span> Family of roundworms

The Ascarididae are a family of the large intestinal roundworms. Members of the family are intestinal parasites, infecting all classes of vertebrates. It includes a number of genera, the most well known of which are:

<i>Toxascaris leonina</i> Species of roundworm

Toxascaris leonina is a common parasitic roundworm found in dogs, cats, foxes, and related host species. T. leonina is an ascarid nematode, a worldwide distributed helminth parasite which is in a division of eukaryotic parasites that, unlike external parasites such as lice and fleas, live inside their host. The definitive hosts of T. leonina include canids and felines (cats), while the intermediate hosts are usually rodents, such as mice or rats. Infection occurs in the definitive host when the animal eats an infected rodent. While T. leonina can occur in either dogs or cats, it is far more frequent in cats.

<span class="mw-page-title-main">Nematode</span> Phylum of worms with tubular digestive systems with openings at both ends

The nematodes, roundworms or eelworms constitute the phylum Nematoda. They are a diverse animal phylum inhabiting a broad range of environments. Most species are free-living, feeding on microorganisms, but there are many that are parasitic. The parasitic worms (helminths) are the cause of soil-transmitted helminthiases.

Ascaricides are drugs to treat ascariasis that is caused by infections with parasitic nematodes (roundworms) of the genus Ascaris. The large roundworm of pigs typically infects pigs while Ascaris lumbricoides affects human populations, typically in sub-tropical and tropical areas with poor sanitation. Ascaricides belong to the group of drugs collectively called anthelmintics which expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host.

<span class="mw-page-title-main">Anthelmintic</span> Antiparasitic drugs that expel parasitic worms (helminths) from the body

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges or vermicides. Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis. These drugs are also used to treat infected animals.

<i>Baylisascaris procyonis</i> Species of roundworm

Baylisascaris procyonis, also known by the common name of raccoon roundworm, is a roundworm nematode, found ubiquitously in raccoons, the definitive hosts. It is named after H. A. Baylis, who studied them in the 1920s–30s, and Greek askaris. Baylisascaris larvae in paratenic hosts can migrate, causing larva migrans. Baylisascariasis as the zoonotic infection of humans is rare, though extremely dangerous due to the ability of the parasite's larvae to migrate into brain tissue and cause damage. Concern for human infection has been increasing over the years due to urbanization of rural areas resulting in the increase in proximity and potential human interaction with raccoons.

<span class="mw-page-title-main">Soil-transmitted helminthiasis</span> Roundworm infection contracted from contaminated soil

Soil-transmitted helminthiasis is a type of worm infection (helminthiasis) caused by different species of roundworms. It is caused specifically by those worms which are transmitted through soil contaminated with faecal matter and are therefore called soil-transmitted helminths. Three types of soil-transmitted helminthiasis can be distinguished: ascariasis, hookworm infection and whipworm infection. These three types of infection are therefore caused by the large roundworm A. lumbricoides, the hookworms Necator americanus or Ancylostoma duodenale and by the whipworm Trichuris trichiura.

Lani Sue Stephenson was an American parasitologist and nutritionist, "a pioneer in field-based studies on nutrition–parasite interactions".

References

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  9. 1 2 Leles D, Gardner SL, Reinhard K, Iniguez A, Araujo A (2012). "Are Ascaris lumbricoides and Ascaris suum a single species?". Parasites & Vectors. 5 (42): 42. doi: 10.1186/1756-3305-5-42 . PMC   3293767 . PMID   22348306.