BTAF1

BTAF1
Identifiers
Aliases	BTAF1 , MOT1, TAF(II)170, TAF172, TAFII170, B-TFIID TATA-box binding protein associated factor 1
External IDs	OMIM: 605191 MGI: 2147538 HomoloGene: 31978 GeneCards: BTAF1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	92,030,325 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	36,990,152 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; Germinal epithelium; ; prosencephalon; ; vagina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; DNA binding ; nucleotide binding ; hydrolase activity ; ATP binding ; GO:0008026 helicase activity ; GO:0001948 protein binding ;
Cellular component	intracellular membrane-bounded organelle ; nucleus ; nucleoplasm ;
Biological process	negative regulation of transcription, DNA-templated ; negative regulation of chromatin binding ;
	Sources:Amigo / QuickGO
Orthologs
	9044
	107182
	ENSG00000095564
	ENSMUSG00000040565
	O14981 ; Q2M1V9
	E9QAE3
	NM_003972
	NM_001080706
	NP_003963 ; NP_003963.1
	NP_001074175
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2022

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.^[5]^[6]^[7]

Function

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM]^[7]

Interactions

BTAF1 has been shown to interact with TATA binding protein.^[6]^[8]

Related Research Articles

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Transcription factor II D (TF_IID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins. Before the start of transcription, the transcription Factor II D (TF_IID) complex binds to the TATA box in the core promoter of the gene.

DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the POLR2C gene.

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.

Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene.

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 gene.

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000095564 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040565 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A. 94 (22): 11827–32. Bibcode:1997PNAS...9411827V. doi: 10.1073/pnas.94.22.11827 . PMC 23617 . PMID 9342322.
1 2 Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol. 18 (3): 1701–10. doi:10.1128/MCB.18.3.1701. PMC 108885 . PMID 9488487.
1 2 "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)".
↑ Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . PMC 20825 . PMID 9159119.

External links

Human BTAF1 genome location and BTAF1 gene details page in the UCSC Genome Browser .

Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat". EMBO J. 14 (2): 321–8. doi:10.1002/j.1460-2075.1995.tb07006.x. PMC 398086 . PMID 7835343.
Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. doi: 10.1074/jbc.270.5.2274 . PMID 7836461.
Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. doi:10.1128/JVI.68.11.7188-7199.1994. PMC 237158 . PMID 7933101.
Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295–9. Bibcode:1994Natur.367..295K. doi:10.1038/367295a0. PMID 8121496. S2CID 4362048.
Wang Z, Morris GF, Rice AP, Xiong W, Morris CB (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. doi:10.1097/00042560-199606010-00005. PMID 8680883.
Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly". J. Virol. 70 (8): 5025–34. doi:10.1128/JVI.70.8.5025-5034.1996. PMC 190456 . PMID 8764009.
Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". J. Virol. 70 (8): 5503–10. doi:10.1128/JVI.70.8.5503-5510.1996. PMC 190508 . PMID 8764062.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi: 10.1074/jbc.272.11.6951 . PMID 9054383.
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . PMC 20825 . PMID 9159119.
Van Der Knaap JA, Van Den Boom V, Kuipers J, Van Eijk MJ, Van Der Vliet PC, Timmers HT (2000). "The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization". Biochem. J. 345 (3): 521–7. doi:10.1042/0264-6021:3450521. PMC 1220786 . PMID 10642510.
Wadhwa R, Yaguchi T, Hasan MK, Taira K, Kaul SC (2003). "Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation". Biochem. Biophys. Res. Commun. 302 (4): 735–42. doi:10.1016/S0006-291X(03)00226-2. PMID 12646231.
Pereira LA, Klejman MP, Ruhlmann C, Kavelaars F, Oulad-Abdelghani M, Timmers HT, Schultz P (2004). "Molecular architecture of the basal transcription factor B-TFIID". J. Biol. Chem. 279 (21): 21802–7. doi: 10.1074/jbc.M313519200 . PMID 14988402.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Klejman MP, Pereira LA, van Zeeburg HJ, Gilfillan S, Meisterernst M, Timmers HT (2004). "NC2α Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein". Mol. Cell. Biol. 24 (22): 10072–82. doi:10.1128/MCB.24.22.10072-10082.2004. PMC 525489 . PMID 15509807.
Grob P, Cruse MJ, Inouye C, Peris M, Penczek PA, Tjian R, Nogales E (2006). "Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues". Structure. 14 (3): 511–20. doi: 10.1016/j.str.2005.11.020 . PMID 16531235.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000095564 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040565 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9342322-5] van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A. 94 (22): 11827–32. Bibcode:1997PNAS...9411827V. doi: 10.1073/pnas.94.22.11827 . PMC 23617 . PMID 9342322.

[pmid9488487-6] 1 2 Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol. 18 (3): 1701–10. doi:10.1128/MCB.18.3.1701. PMC 108885 . PMID 9488487.

[entrez-7] 1 2 "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)".

[pmid9159119-8] Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . PMC 20825 . PMID 9159119.

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