Bacopa monnieri | |
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Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Eudicots |
Clade: | Asterids |
Order: | Lamiales |
Family: | Plantaginaceae |
Genus: | Bacopa |
Species: | B. monnieri |
Binomial name | |
Bacopa monnieri | |
Synonyms | |
Bacopa monnieraHayata & Matsum. Contents |
Bacopa monnieri is a perennial, creeping herb native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America. [2] It is known by the common names water hyssop, [1] waterhyssop, brahmi, [2] thyme-leafed gratiola, herb of grace, [2] and Indian pennywort. [2] Bacopa monnieri is used in Ayurveda. In 2019, the US Food and Drug Administration (FDA) warned manufacturers of dietary supplement products containing Bacopa monnieri against making illegal and unproven claims that the herb can treat various diseases. [3] [4] [5]
Bacopa monnieri is a non-aromatic herb. The leaves of this plant are succulent, oblong, and 4–6 mm (0.16–0.24 in) thick. Leaves are oblanceolate and are arranged oppositely on the stem. The flowers are small, actinomorphic and white, with four to five petals. It can even grow in slightly brackish conditions. Propagation is often achieved through cuttings. [6]
Bacopa monnieri is one of the most widespread Bacopa species. It commonly grows in marshy areas throughout India, Nepal, Sri Lanka, China, Pakistan, Taiwan, Vietnam, tropical and southern Africa, on Madagascar, in Australia, in the Caribbean as well as in Middle and South America. [2] It is also found in Florida, Louisiana, Texas, and Hawaii. [1] [7]
It used to be found growing wild in freshwater swamps of Singapore and nearby regions known as beremi. [8]
Bacopa monnieri is used in Ayurvedic traditional medicine in the belief it may improve memory and various other ailments. [9] Systematic reviews of preliminary research found that Bacopa monnieri may improve cognition, specifically memory and learning, [9] [10] although the effect was measurable only after several weeks of use. [11]
In 2019, the FDA issued warning letters to manufacturers of dietary supplements containing Bacopa monnieri that advertised health claims for treating or preventing stomach disease, Alzheimer's disease, hypoglycemia, blood pressure, and anxiety were unproven and illegal. [4] [5] The FDA stated that Bacopa monnieri products have not been approved for these or any medical purposes, and that advertising for its use in treating Alzheimer's disease is a scam. [3]
The most commonly reported adverse effects of Bacopa monnieri in humans are nausea, increased intestinal motility, and gastrointestinal upset. [9]
The best characterized phytochemicals in Bacopa monnieri are dammarane-type triterpenoid saponins known as bacosides, with jujubogenin or pseudo-jujubogenin moieties as aglycone units. [12] Bacosides comprise a family of 12 known analogs. [13] Other saponins called bacopasides I–XII were identified. [14] The alkaloids brahmine, nicotine, and herpestine have been catalogued, along with D-mannitol, apigenin, hersaponin, monnierasides I–III, cucurbitacin and plantainoside B. [15] [16] [17]
Stevia is a sweet sugar substitute extracted from the leaves of the plant species Stevia rebaudiana native to Paraguay and Brazil.
Lonicera japonica, known as Japanese honeysuckle and golden-and-silver honeysuckle, is a species of honeysuckle native to eastern Asia, including many parts of China. It is often grown as an ornamental plant, but has become an invasive species in a number of countries. Japanese honeysuckle is used in traditional Chinese medicine.
Saponins, also selectively referred to as triterpene glycosides, are bitter-tasting usually toxic plant-derived organic chemicals that have a foamy quality when agitated in water. They are widely distributed but found particularly in soapwort, a flowering plant, the soapbark tree and soybeans. They are used in soaps, medicines, fire extinguishers, speciously as dietary supplements, for synthesis of steroids, and in carbonated beverages. Saponins are both water and fat soluble, which gives them their useful soap properties. Some examples of these chemicals are glycyrrhizin and quillaia, a bark extract used in beverages.
Nootropics are numerous natural, semi-synthetic and synthetic molecules which purportedly improve cognitive functions.
QS-21 is a purified plant extract used as a vaccine adjuvant. It is derived from the soap bark tree, which is native to the countries of Chile, Peru, and Bolivia. The crude drug is imported from Peru and Chile.
Rhodiola rosea is a perennial flowering plant in the family Crassulaceae. It grows naturally in wild Arctic regions of Europe, Asia, and North America, and can be propagated as a groundcover.
Cyclanthera pedata, known as caigua, is a herbaceous vine grown for its edible fruit, which is predominantly used as a vegetable. It is known from cultivation only, and its use goes back many centuries as evidenced by ancient phytomorphic ceramics from Peru depicting the fruits.
Bacopa is a genus of 70–100 aquatic plants belonging to the family Plantaginaceae. It is commonly known as waterhyssop.
Calendula officinalis, the pot marigold, common marigold, ruddles, Mary's gold or Scotch marigold, is a flowering plant in the daisy family Asteraceae. It is probably native to southern Europe, though its long history of cultivation makes its precise origin unknown, and it may possibly be of garden origin. It is also widely naturalised farther north in Europe and elsewhere in warm temperate regions of the world.
Picamilon is a drug formed by a synthetic combination of niacin and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 and further studied in both Russia and Japan as a prodrug of GABA.
Asparagus racemosus is a species of asparagus native from Africa through southern Asia, including the Indian subcontinent, to northern Australia. It grows 1–2 m tall and prefers to take root in gravelly, rocky soils high up in piedmont plains, at 1,300–1,400 m (4,300–4,600 ft) elevation. It was botanically described in 1799. Because of its multiple uses, the demand for Asparagus racemosus is constantly on the rise. Due to destructive harvesting, combined with habitat destruction, and deforestation, the plant is now considered "endangered" in its natural habitat.
Triterpenes are a class of terpenes composed of six isoprene units with the molecular formula C30H48; they may also be thought of as consisting of three terpene units. Animals, plants and fungi all produce triterpenes, including squalene, the precursor to all steroids.
Ginsenosides or panaxosides are a class of natural product steroid glycosides and triterpene saponins. Compounds in this family are found almost exclusively in the plant genus Panax (ginseng), which has a long history of use in traditional medicine that has led to the study of pharmacological effects of ginseng compounds. As a class, ginsenosides exhibit a large variety of subtle and difficult-to-characterize biological effects when studied in isolation.
Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins.
Cucurbitacins are a class of biochemical compounds that some plants – notably members of the pumpkin and gourd family, Cucurbitaceae – produce and which function as a defense against herbivores. Cucurbitacins and their derivatives have also been found in many other plant families, in some mushrooms and even in some marine mollusks.
Cucurbitane is a class of tetracyclic chemical compounds with formula C
30H
54. It is a polycyclic hydrocarbon, specifically triterpene. It is also an isomer of lanostane, from which it differs by the formal shift of a methyl group from the 10 to the 9β position in the standard steroid numbering scheme.
Aesculus chinensis, the Chinese horse chestnut or Chinese buckeye, is a deciduous temperate tree species in the genus Aesculus found across China. It was first successfully introduced to Britain in 1912 by plant collector William Purdom, who collected six young plants from the grounds of a temple in the western hills of Beijing, and brought them back to Veitch's Nursery in Coombe Hill near London. Purdom's correspondence regarding this event are held in the archives of the Arnold Arboretum. One plant was sent to the Royal Botanic Gardens Kew and two to the Arnold Arboretum in Boston. The original tree at Kew no longer exists but a young tree grafted from the original now grows in the Rhododendron Dell.
Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri. Its major constituents include the saponins bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C, and bacopasaponin C. The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.
Bacopasides are triterpene saponins isolated from Bacopa monnieri.
Pseudoginsenoside F11 is a chemical natural product found in American ginseng but not in Asian ginseng, although it has similar properties to the Asian ginseng compound ginsenoside Rf. The molecule is a triterpenoid saponin member of the dammarane family and contains a four-ring rigid skeleton. Compounds in the ginsenoside family are found almost exclusively in plants of the genus Panax. A wide variety of difficult-to-characterize in vitro effects have been reported for the compounds in isolation. Pseudoginsenoside F11 and its derivatives are sometimes referred to as having an ocotillol-type skeleton structure.