Bacopa monnieri

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Bacopa monnieri
Starr 010818-0007 Bacopa monnieri.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Lamiales
Family: Plantaginaceae
Genus: Bacopa
Species:
B. monnieri
Binomial name
Bacopa monnieri
Synonyms

Bacopa monnieraHayata & Matsum.
Bramia monnieri(L.) Pennell
Gratiola monnieriaL.
Herpestes monnieria(L.) Kunth
Herpestis faurieiH.Lev.
Herpestis monniera
Herpestris monnieria
Lysimachia monnieriL.
Moniera cuneifoliaMichx.

Contents

Bacopa monnieri is a perennial, creeping herb native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America. [2] It is known by the common names water hyssop, [1] waterhyssop, brahmi, [2] thyme-leafed gratiola, herb of grace, [2] and Indian pennywort. [2] Bacopa monnieri is used in Ayurveda. In 2019, the US Food and Drug Administration (FDA) warned manufacturers of dietary supplement products containing Bacopa monnieri against making illegal and unproven claims that the herb can treat various diseases. [3] [4] [5]

Description

Bacopa monnieri in Hyderabad, India Bacopa monnieri W IMG 1612.jpg
Bacopa monnieri in Hyderabad, India

Bacopa monnieri is a non-aromatic herb. The leaves of this plant are succulent, oblong, and 4–6 mm (0.16–0.24 in) thick. Leaves are oblanceolate and are arranged oppositely on the stem. The flowers are small, actinomorphic and white, with four to five petals. It can even grow in slightly brackish conditions. Propagation is often achieved through cuttings. [6]

Ecology

Bacopa monnieri is one of the most widespread Bacopa species. It commonly grows in marshy areas throughout India, Nepal, Sri Lanka, China, Pakistan, Taiwan, Vietnam, tropical and southern Africa, on Madagascar, in Australia, in the Caribbean as well as in Middle and South America. [2] It is also found in Florida, Louisiana, Texas, and Hawaii. [1] [7]

It used to be found growing wild in freshwater swamps of Singapore and nearby regions known as beremi. [8]

Research and regulation

Bacopa monnieri is used in Ayurvedic traditional medicine in the belief it may improve memory and various other ailments. [9] Systematic reviews of preliminary research found that Bacopa monnieri may improve cognition, specifically memory and learning, [9] [10] although the effect was measurable only after several weeks of use. [11]

In 2019, the FDA issued warning letters to manufacturers of dietary supplements containing Bacopa monnieri that advertised health claims for treating or preventing stomach disease, Alzheimer's disease, hypoglycemia, blood pressure, and anxiety were unproven and illegal. [4] [5] The FDA stated that Bacopa monnieri products have not been approved for these or any medical purposes, and that advertising for its use in treating Alzheimer's disease is a scam. [3]

Adverse effects

The most commonly reported adverse effects of Bacopa monnieri in humans are nausea, increased intestinal motility, and gastrointestinal upset. [9]

Phytochemistry

The best characterized phytochemicals in Bacopa monnieri are dammarane-type triterpenoid saponins known as bacosides, with jujubogenin or pseudo-jujubogenin moieties as aglycone units. [12] Bacosides comprise a family of 12 known analogs. [13] Other saponins called bacopasides I–XII were identified. [14] The alkaloids brahmine, nicotine, and herpestine have been catalogued, along with D-mannitol, apigenin, hersaponin, monnierasides I–III, cucurbitacin and plantainoside B. [15] [16] [17]

Related Research Articles

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<i>Asparagus racemosus</i> Species of flowering plant

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<span class="mw-page-title-main">Ginsenoside</span> Class of steroids

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<span class="mw-page-title-main">Cucurbitacin</span> Class of biochemical compounds

Cucurbitacins are a class of biochemical compounds that some plants – notably members of the pumpkin and gourd family, Cucurbitaceae – produce and which function as a defense against herbivores. Cucurbitacins and their derivatives have also been found in many other plant families, in some mushrooms and even in some marine mollusks.

<span class="mw-page-title-main">Cucurbitane</span> Chemical compound

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30
H
54
. It is a polycyclic hydrocarbon, specifically triterpene. It is also an isomer of lanostane, from which it differs by the formal shift of a methyl group from the 10 to the 9β position in the standard steroid numbering scheme.

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<span class="mw-page-title-main">Bacoside A</span>

Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri. Its major constituents include the saponins bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C, and bacopasaponin C. The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.

Bacopasides are triterpene saponins isolated from Bacopa monnieri.

<span class="mw-page-title-main">Pseudoginsenoside F11</span> Chemical compound

Pseudoginsenoside F11 is a chemical natural product found in American ginseng but not in Asian ginseng, although it has similar properties to the Asian ginseng compound ginsenoside Rf. The molecule is a triterpenoid saponin member of the dammarane family and contains a four-ring rigid skeleton. Compounds in the ginsenoside family are found almost exclusively in plants of the genus Panax. A wide variety of difficult-to-characterize in vitro effects have been reported for the compounds in isolation. Pseudoginsenoside F11 and its derivatives are sometimes referred to as having an ocotillol-type skeleton structure.

References

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  2. 1 2 3 4 5 6 "Bacopa monnieri". Germplasm Resources Information Network . Agricultural Research Service, United States Department of Agriculture . Retrieved 2008-03-13.
  3. 1 2 "Health fraud scams: Unproven Alzheimer's disease products (Bacopa monnieri listed)". US Food and Drug Administration. 22 December 2018. Retrieved 11 May 2019.
  4. 1 2 William A Correll, Jr. (5 February 2019). "FDA Warning Letter: Peak Nootropics LLC aka Advanced Nootropics". Office of Compliance, Center for Food Safety and Applied Nutrition, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 11 May 2019.
  5. 1 2 William A Correll, Jr. (5 February 2019). "FDA Warning Letter: TEK Naturals". Office of Compliance, Center for Food Safety and Applied Nutrition, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 11 May 2019.
  6. Oudhia, Pankaj (2004). "Bramhi (Bacopa monnieri)". Society for Parthenium Management (SOPAM). Retrieved July 30, 2017.
  7. "Plants of Louisiana". warcapps.usgs.gov. Retrieved 2021-07-23.
  8. Khir Johari (Oct–Dec 2021). "The Role of Foraging in Malay Cuisine". BiblioAsia. Vol. 17, no. 3. National Library Board, Singapore. pp. 20–23.
  9. 1 2 3 Aguiar, Sebastian; Borowski, Thomas (2013). "Neuropharmacological review of the nootropic herb Bacopa monnieri". Rejuvenation Research. 16 (4): 313–326. doi:10.1089/rej.2013.1431. ISSN   1557-8577. PMC   3746283 . PMID   23772955.
  10. Kongkeaw, C; Dilokthornsakul, P; Thanarangsarit, P; Limpeanchob, N; Norman Scholfield, C (2014). "Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract". Journal of Ethnopharmacology. 151 (1): 528–35. doi:10.1016/j.jep.2013.11.008. PMID   24252493.
  11. Neale, Chris; Camfield, David; Reay, Jonathon; Stough, Con; Scholey, Andrew (5 February 2013). "Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes". British Journal of Clinical Pharmacology. 75 (3): 728–737. doi:10.1111/bcp.12002. ISSN   0306-5251. PMC   3575939 . PMID   23043278.
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  13. Garai, S; Mahato, SB; Ohtani, K; Yamasaki, K (2009). "Dammarane triterpenoid saponins from Bacopa monnieri". Can J Chem. 87 (9): 1230–1234. doi:10.1139/V09-111.
  14. Chakravarty, A.K; Garai, S.; Masuda, K; Nakane, T; Kawahara, N. (2003). "Bacopasides III–V: Three new triterpenoid glycosides from Bacopa monnieri". Chem Pharm Bull. 51 (2): 215–217. doi: 10.1248/cpb.51.215 . PMID   12576661.
  15. Chatterji, N; Rastogi, RP; Dhar, ML (1965). "Chemical examination of Bacopa monniera Wettst: Part II—Isolation of chemical constituents". Ind J Chem. 3: 24–29.
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  17. Bhandari, Pamita; Kumar, Neeraj; Singh, Bikram; Kaul, Vijay K. (2007). "Cucurbitacins from Bacopa monnieri". Phytochemistry. 68 (9): 1248–1254. Bibcode:2007PChem..68.1248B. doi:10.1016/j.phytochem.2007.03.013. ISSN   0031-9422. PMID   17442350.